| # | Title | Journal | Year | Citations |
|---|
| 1 | Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians | Journal of Pharmacology and Experimental Therapeutics | 1994 | 1,873 |
| 2 | In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses | Nature | 2009 | 1,002 |
| 3 | Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1 | Cancer Science | 2004 | 640 |
| 4 | Environmental release and behavior of brominated flame retardants | Environment International | 2003 | 592 |
| 5 | Evaluation of the new system (umu-test) for the detection of environmental mutagens and carcinogens | Mutation Research - Environmental Mutagenesis and Related Subjects Including Methodology | 1985 | 548 |
| 6 | An extensive outbreak of staphylococcal food poisoning due to low-fat milk in Japan: estimation of enterotoxin A in the incriminated milk and powdered skim milk | Epidemiology and Infection | 2003 | 401 |
| 7 | Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes | Carcinogenesis | 1992 | 369 |
| 8 | Estrogenic Activities of 517 Chemicals by Yeast Two-Hybrid Assay. | Journal of Health Science | 2000 | 364 |
| 9 | Pandemic Spread of an O3:K6 Clone of Vibrio parahaemolyticus and Emergence of Related Strains Evidenced by Arbitrarily Primed PCR and toxRS Sequence Analyses | Journal of Clinical Microbiology | 2000 | 350 |
| 10 | Human Intelectin Is a Novel Soluble Lectin That Recognizes Galactofuranose in Carbohydrate Chains of Bacterial Cell Wall | Journal of Biological Chemistry | 2001 | 316 |
| 11 | Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma Lucidum | Phytochemistry | 1998 | 313 |
| 12 | Progesterone and Testosterone Hydroxylation by Cytochromes P450 2C19, 2C9, and 3A4 in Human Liver Microsomes | Archives of Biochemistry and Biophysics | 1997 | 283 |
| 13 | Loss of a conserved 7‐methylguanosine modification in 16S rRNA confers low‐level streptomycin resistance in bacteria | Molecular Microbiology | 2007 | 249 |
| 14 | A rapid and efficient single-cell manipulation method for screening antigen-specific antibody–secreting cells from human peripheral blood | Nature Medicine | 2009 | 247 |
| 15 | Direct Metagenomic Detection of Viral Pathogens in Nasal and Fecal Specimens Using an Unbiased High-Throughput Sequencing Approach | PLoS ONE | 2009 | 240 |
| 16 | Catalytic properties of polymorphic human cytochrome P450 1B1 variants | Carcinogenesis | 1999 | 236 |
| 17 | Activation of procarcinogens by human cytochrome P450 enzymes | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis | 1998 | 229 |
| 18 | Roles of NADPH-P450 Reductase and Apo- and Holo-Cytochrome b5 on Xenobiotic Oxidations Catalyzed by 12 Recombinant Human Cytochrome P450s Expressed in Membranes of Escherichia coli | Protein Expression and Purification | 2002 | 224 |
| 19 | SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals | Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis | 1987 | 221 |
| 20 | Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes | Archives of Toxicology | 1999 | 209 |
| 21 | Anti-HIV-1 Activity of Herbs in Labiatae. | Biological and Pharmaceutical Bulletin | 1998 | 201 |
| 22 | Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice | Carcinogenesis | 2002 | 197 |
| 23 | Antibacterial activity of α-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics | Phytomedicine | 2005 | 184 |
| 24 | The Membrane-type Collectin CL-P1 Is a Scavenger Receptor on Vascular Endothelial Cells | Journal of Biological Chemistry | 2001 | 181 |
| 25 | Determination of Acetamiprid, Imidacloprid, and Nitenpyram Residues in Vegetables and Fruits by High-Performance Liquid Chromatography with Diode-Array Detection | Journal of Agricultural and Food Chemistry | 2002 | 179 |
| 26 | Identification of Kudoa septempunctata as the Causative Agent of Novel Food Poisoning Outbreaks in Japan by Consumption of Paralichthys olivaceus in Raw Fish | Clinical Infectious Diseases | 2012 | 173 |
| 27 | Determination of Neonicotinoid Pesticide Residues in Vegetables and Fruits with Solid Phase Extraction and Liquid Chromatography Mass Spectrometry | Journal of Agricultural and Food Chemistry | 2003 | 172 |
| 28 | Two epidemics of diarrhoeal disease possibly caused byPlesiomonas shigelloides | The Journal of Hygiene | 1978 | 171 |
| 29 | Roles of Cytochromes P450 1A2 and 3A4 in the Oxidation of Estradiol and Estrone in Human Liver Microsomes | Chemical Research in Toxicology | 1998 | 171 |
| 30 | Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs | Drug Metabolism and Disposition | 1996 | 171 |
| 31 | Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer | Pharmacogenetics and Genomics | 2000 | 170 |
| 32 | Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans | Archives of Toxicology | 1997 | 166 |
| 33 | A Low Prevalence of Coronary Heart Disease among Subjects with Increased High-Density Lipoprotein Cholesterol Levels, Including Those with Plasma Cholesteryl Ester Transfer Protein Deficiency | Preventive Medicine | 1998 | 163 |
| 34 | A Large Outbreak of Acute Gastroenteritis Associated with Astrovirus among Students and Teachers in Osaka, Japan | Journal of Infectious Diseases | 1994 | 160 |
| 35 | Lack of Electron Transfer from Cytochrome b5 in Stimulation of Catalytic Activities of Cytochrome P450 3A4 | Journal of Biological Chemistry | 1996 | 159 |
| 36 | Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009 | Drug Metabolism and Disposition | 2001 | 159 |
| 37 | Enterovirus 71 from Fatal and Nonfatal Cases of Hand, Foot and Mouth Disease Epidemics in Malaysia, Japan and Taiwan in 1997-1998 | Japanese Journal of Infectious Diseases | 1999 | 155 |
| 38 | Comparative Studies on the Catalytic Roles of Cytochrome P450 2C9 and Its Cys- and Leu-Variants in the Oxidation of Warfarin, Flurbiprofen, and Diclofenac by Human Liver Microsomes | Biochemical Pharmacology | 1998 | 153 |
| 39 | Perfluorooctanesulfonate and perfluorooctanoate in raw and treated tap water from Osaka, Japan | Chemosphere | 2008 | 152 |
| 40 | Fate of Perfluorooctanesulfonate and perfluorooctanoate in drinking water treatment processes | Water Research | 2011 | 152 |
| 41 | Formation of brominated dibenzofurans from the photolysis of flame retardant decabromobiphenyl ether in hexane solution by UV and sun light | Bulletin of Environmental Contamination and Toxicology | 1987 | 151 |
| 42 | Metabolism of Benzo[a]pyrene to trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene by Recombinant Human Cytochrome P450 1B1 and Purified Liver Epoxide Hydrolase | Chemical Research in Toxicology | 1999 | 151 |
| 43 | Clinical Significance ofEscherichia albertii | Emerging Infectious Diseases | 2012 | 151 |
| 44 | Molecular Cloning and Characterization of the Gene Coding for Azoreductase from Bacillus sp. OY1-2 Isolated from Soil | Journal of Biological Chemistry | 2001 | 149 |
| 45 | Specificity and sensitivity of Salmonella typhimurium YG1041 and YG1042 strains possesing elevated levels of both nitroreductase and acetyltransferase activity | Mutation Research - Environmental Mutagenesis and Related Subjects Including Methodology | 1993 | 148 |
| 46 | Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice | International Immunopharmacology | 2009 | 148 |
| 47 | PandemicVibrio parahaemolyticusO3:K6, Europe | Emerging Infectious Diseases | 2005 | 146 |
| 48 | New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan | Antimicrobial Agents and Chemotherapy | 2016 | 146 |
| 49 | Detection of Kanamycin-Resistant Mycobacterium tuberculosis by Identifying Mutations in the 16S rRNA Gene | Journal of Clinical Microbiology | 1998 | 146 |
| 50 | Antimutagenic effect of resveratrol against Trp-P-1 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis | 1997 | 141 |
