MRC Toxicology Unit

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#	Title	Journal	Year	Citations
1	The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1	Nature Cell Biology	2007	441
2	Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells	Carcinogenesis	1992	280
3	An athymic nude mutation in the rat	Nature	1978	233
4	The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells	Oncogene	2013	224
5	Smoking induces differential miRNA expression in human spermatozoa: A potential transgenerational epigenetic concern?	Epigenetics	2012	212
6	Increased membrane permeability of apoptotic thymocytes: A flow cytometric study	Cytometry	1993	195
7	Characterization of novel markers of senescence and their prognostic potential in cancer	Cell Death and Disease	2014	186
8	Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability	Molecular and Cellular Biology	2010	179
9	Daxx: death or survival protein?	Trends in Cell Biology	2006	177
10	Physiological Concentrations of K+ Inhibit Cytochrome c-dependent Formation of the Apoptosome	Journal of Biological Chemistry	2001	169
11	The Tumor Suppressor RASSF1A and MAP-1 Link Death Receptor Signaling to Bax Conformational Change and Cell Death	Molecular Cell	2005	166
12	Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair	Nature Communications	2018	164
13	Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response	Cell Death and Differentiation	2009	156
14	Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease	Cell Death and Disease	2016	151
15	Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea	PLoS Genetics	2010	141
16	The unfolded protein response in neurodegenerative disorders – therapeutic modulation of the PERK pathway	FEBS Journal	2019	137
17	The Biologically Effective Dose in Inhalation Nanotoxicology	Accounts of Chemical Research	2013	135
18	The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER	PLoS Pathogens	2014	129
19	Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis	Critical Care	2005	119
20	Fluorimetric determination of oxidised and reduced glutathione in cells and tissues by high-performance liquid chromatography following derivatization with dansyl chloride	Biomedical Applications	1991	114
21	Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons	Journal of Physiology	2008	112
22	New insights into the role of PML in tumour suppression	Cell Research	2008	111
23	Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster	Cell Death and Differentiation	2012	111
24	Studies on the toxicity and metabolism of cadmium-thionein	Biochemical Pharmacology	1977	105
25	Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson’s disease	Cell Death and Disease	2013	104
26	An investigation of the role of metallothioneins in protection against the acute toxicity of the cadmium ion	Biochemical Pharmacology	1976	102
27	Activation of Transcription by Estrogen Receptor α and β Is Cell Type- and Promoter-dependent	Journal of Biological Chemistry	1999	92
28	Quantification of Apoptosis and Necrosis by Flow Cytometry	Acta Oncológica	1993	88
29	The Metallothioneins	Biochemical Society Transactions	1975	86
30	The time-course of cadmium-thionein synthesis in the rat	Biochemical Pharmacology	1976	86
31	A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant	Biochemical Journal	1993	86
32	A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes	Biochemical Journal	1996	85
33	Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1	Cell Death and Disease	2014	85
34	Unravelling mitochondrial pathways to Parkinson's disease	British Journal of Pharmacology	2014	84
35	Trans‐acting translational regulatory RNA binding proteins	Wiley Interdisciplinary Reviews RNA	2018	79
36	Development of resistance to cytotoxicity during aflatoxin carcinogenesis	Nature	1977	77
37	Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin	Cell Death and Differentiation	2009	77
38	Thymocyte apoptosis as a mechanism for tributyltin-induced thymic atrophy in vivo	Archives of Toxicology	1993	75
39	Chemoprevention of Breast Cancer by Tamoxifen: Risks and Opportunities	Critical Reviews in Toxicology	2000	72
40	Biomarkers of genotoxicity of urban air pollution	Mutation Research - Genetic Toxicology and Environmental Mutagenesis	2001	72
41	miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress	Cell Death and Disease	2013	69
42	The formation of mixed disulphides in rat lung following paraquat administration Correlation with changes in intermediary metabolism	Biochimica Et Biophysica Acta - General Subjects	1982	68
43	Regional Blood—Brain Glucose Transfer in the Rat: A Novel Double-Membrane Kinetic Analysis	Journal of Cerebral Blood Flow and Metabolism	1986	66
44	Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro	International Journal of Biochemistry and Cell Biology	2005	65
45	Mutagenicity, carcinogenicity, and teratogenicity of acrylonitrile	Mutation Research - Reviews in Mutation Research	1999	64
46	Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia	Human Reproduction	2013	64
47	Ex Vivo Explant Cultures of Non–Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy	Cancer Research	2017	64
48	Genomic instability in mutant p53 cancer cells upon entotic engulfment	Nature Communications	2018	64
49	Epidemiological and experimental aspects of metal carcinogenesis: physicochemical properties, kinetics, and the active species.	Environmental Health Perspectives	1991	63
50	The effect of selenium on the brain uptake of methylmercury	Archives of Toxicology	1977	62

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