| # | Title | Journal | Year | Citations |
|---|
| 1 | Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial | Lancet, The | 2016 | 1,493 |
| 2 | Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial | BMJ: British Medical Journal | 2000 | 1,413 |
| 3 | Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution | Nature | 2017 | 1,287 |
| 4 | Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus | Nature Genetics | 1995 | 712 |
| 5 | Association of Comorbid Conditions and Mortality in Hemodialysis Patients in Europe, Japan, and the United States: The Dialysis Outcomes and Practice Patterns Study (DOPPS) | Journal of the American Society of Nephrology: JASN | 2003 | 688 |
| 6 | Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial | Lancet, The | 2007 | 660 |
| 7 | British Guideline on the Management of Asthma | Thorax | 2008 | 655 |
| 8 | LMNA, encoding lamin A/C, is mutated in partial lipodystrophy | Nature Genetics | 2000 | 653 |
| 9 | Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study | Lancet, The | 2005 | 620 |
| 10 | A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment | Cancer | 2007 | 559 |
| 11 | Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study | Lancet Infectious Diseases, The | 2015 | 553 |
| 12 | *">Safety and Tolerability of Nonbronchoscopic Lavage in ARDS* | Chest | 2005 | 528 |
| 13 | The definition of acute kidney injury and its use in practice | Kidney International | 2015 | 517 |
| 14 | COPD exacerbations: definitions and classifications | European Respiratory Journal | 2003 | 511 |
| 15 | The β-Agonist Lung Injury Trial (BALTI) | American Journal of Respiratory and Critical Care Medicine | 2006 | 471 |
| 16 | Venetoclax plus LDAC for newly diagnosed AML ineligible for intensive chemotherapy: a phase 3 randomized placebo-controlled trial | Blood | 2020 | 470 |
| 17 | British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children | Journal of Infection | 2009 | 468 |
| 18 | A Randomized Trial of Acyclovir for 7 Days or 21 Days with and without Prednisolone for Treatment of Acute Herpes Zoster | New England Journal of Medicine | 1994 | 411 |
| 19 | Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery | Blood | 2002 | 401 |
| 20 | Systematic comparison of different algorithms for apnoea detection based on electrocardiogram recordings | Medical and Biological Engineering and Computing | 2002 | 366 |
| 21 | Safety and Efficacy of Fedratinib in Patients With Primary or Secondary Myelofibrosis | JAMA Oncology | 2015 | 362 |
| 22 | High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution | Blood | 2002 | 349 |
| 23 | Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus | Leukemia | 2007 | 349 |
| 24 | Optimization of Chemotherapy for Younger Patients With Acute Myeloid Leukemia: Results of the Medical Research Council AML15 Trial | Journal of Clinical Oncology | 2013 | 333 |
| 25 | A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia | Nature Genetics | 2008 | 329 |
| 26 | A search for type 1 diabetes susceptibility genes in families from the United Kingdom | Nature Genetics | 1998 | 316 |
| 27 | Same-Day Diagnostic and Surveillance Data for Tuberculosis via Whole-Genome Sequencing of Direct Respiratory Samples | Journal of Clinical Microbiology | 2017 | 315 |
| 28 | Effect of domestic concentrations of nitrogen dioxide on airway responses to inhaled allergen in asthmatic patients | Lancet, The | 1994 | 314 |
| 29 | Epidemiology of pneumothorax in England | Thorax | 2000 | 314 |
| 30 | Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling | Nature Genetics | 2014 | 311 |
| 31 | Creation, cannulation and survival of arteriovenous fistulae: Data from the Dialysis Outcomes and Practice Patterns Study | Kidney International | 2003 | 307 |
| 32 | Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years | British Journal of Surgery | 2017 | 304 |
| 33 | Mutations in ABCA12 Underlie the Severe Congenital Skin Disease Harlequin Ichthyosis | American Journal of Human Genetics | 2005 | 302 |
| 34 | Immunodeficiency and immunotherapy in multiple myeloma | British Journal of Haematology | 2007 | 297 |
| 35 | CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions | Nature | 2018 | 297 |
| 36 | Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): a randomised, open-label, multicentre, non-inferiority phase 3 study | Lancet Diabetes and Endocrinology,the | 2014 | 293 |
| 37 | Mortality and hospitalization in haemodialysis patients in five European countries: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS) | Nephrology Dialysis Transplantation | 2004 | 276 |
| 38 | Clinical evidence of a graft-versus-Hodgkin's-lymphoma effect after reduced-intensity allogeneic transplantation | Lancet, The | 2005 | 273 |
| 39 | The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo | Blood | 2010 | 271 |
| 40 | Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial | Lancet Oncology, The | 2014 | 270 |
| 41 | Dynamic Relationship between IFN-γ and IL-2 Profile of Mycobacterium tuberculosis-Specific T Cells and Antigen Load | Journal of Immunology | 2007 | 269 |
| 42 | Sick building syndrome | Occupational and Environmental Medicine | 2004 | 262 |
| 43 | Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial | Annals of Oncology | 2019 | 262 |
| 44 | Worldwide, mortality risk is high soon after initiation of hemodialysis | Kidney International | 2014 | 260 |
| 45 | Obesity and Thrombosis | European Journal of Vascular and Endovascular Surgery | 2007 | 259 |
| 46 | Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry | Thorax | 2016 | 257 |
| 47 | De novo LMNA mutations cause a new form of congenital muscular dystrophy | Annals of Neurology | 2008 | 255 |
| 48 | Identifying lineage effects when controlling for population structure improves power in bacterial association studies | Nature Microbiology | 2016 | 247 |
| 49 | Randomised controlled study of early pulsed dye laser treatment of uncomplicated childhood haemangiomas: results of a 1-year analysis | Lancet, The | 2002 | 246 |
| 50 | Sleep quality predicts quality of life and mortality risk in haemodialysis patients: Results from the Dialysis Outcomes and Practice Patterns Study (DOPPS) | Nephrology Dialysis Transplantation | 2007 | 243 |
