| # | Title | Journal | Year | Citations |
|---|
| 1 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,397 |
| 2 | Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes | New England Journal of Medicine | 2008 | 6,447 |
| 3 | Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes | New England Journal of Medicine | 2017 | 5,629 |
| 4 | Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy | New England Journal of Medicine | 2019 | 3,760 |
| 5 | Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study | Lancet, The | 2020 | 3,119 |
| 6 | Treatment of Hypertension in Patients 80 Years of Age or Older | New England Journal of Medicine | 2008 | 2,714 |
| 7 | Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015 | Journal of the American College of Cardiology | 2017 | 2,705 |
| 8 | Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis | Lancet, The | 2016 | 2,464 |
| 9 | Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials | Lancet, The | 2003 | 2,300 |
| 10 | Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials | Lancet, The | 2014 | 1,971 |
| 11 | Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial | Lancet, The | 2007 | 1,864 |
| 12 | CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea | New England Journal of Medicine | 2016 | 1,544 |
| 13 | Worldwide access to treatment for end-stage kidney disease: a systematic review | Lancet, The | 2015 | 1,522 |
| 14 | Non-specific low back pain | Lancet, The | 2017 | 1,484 |
| 15 | Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care | New England Journal of Medicine | 2012 | 1,460 |
| 16 | Interpretation of the evidence for the efficacy and safety of statin therapy | Lancet, The | 2016 | 1,399 |
| 17 | Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients | New England Journal of Medicine | 2009 | 1,288 |
| 18 | Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage | New England Journal of Medicine | 2013 | 1,269 |
| 19 | Profits and pandemics: prevention of harmful effects of tobacco, alcohol, and ultra-processed food and drink industries | Lancet, The | 2013 | 1,248 |
| 20 | Prevalence of intellectual disability: A meta-analysis of population-based studies | Research in Developmental Disabilities | 2011 | 1,227 |
| 21 | Drotrecogin Alfa (Activated) in Adults with Septic Shock | New England Journal of Medicine | 2012 | 1,112 |
| 22 | Effective Exercise for the Prevention of Falls: A Systematic Review and Meta‐Analysis | Journal of the American Geriatrics Society | 2008 | 1,065 |
| 23 | Intensive glucose control and macrovascular outcomes in type 2 diabetes | Diabetologia | 2009 | 1,033 |
| 24 | Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies | British Journal of Cancer | 2005 | 950 |
| 25 | Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis | Journal of Clinical Epidemiology | 2008 | 908 |
| 26 | Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis | Lancet, The | 2012 | 847 |
| 27 | Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk | JAMA - Journal of the American Medical Association | 2019 | 830 |
| 28 | Hypoglycemia and Risk of Death in Critically Ill Patients | New England Journal of Medicine | 2012 | 827 |
| 29 | Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals | Lancet, The | 2018 | 808 |
| 30 | Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis | Lancet, The | 2016 | 792 |
| 31 | Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis | Lancet, The | 2010 | 788 |
| 32 | International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology | Lancet, The | 2015 | 780 |
| 33 | Part I: Frequency of Depression after Stroke: An Updated Systematic Review and Meta-Analysis of Observational Studies | International Journal of Stroke | 2014 | 771 |
| 34 | Clinical Practice Guidelines for the Management of Hypertension in the Community | Journal of Clinical Hypertension | 2014 | 768 |
| 35 | Decline in Estimated Glomerular Filtration Rate and Subsequent Risk of End-Stage Renal Disease and Mortality | JAMA - Journal of the American Medical Association | 2014 | 760 |
| 36 | Achieving child survival goals: potential contribution of community health workers | Lancet, The | 2007 | 734 |
| 37 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial | Lancet Neurology, The | 2008 | 732 |
| 38 | Effects of Different Blood Pressure–Lowering Regimens on Major Cardiovascular Events in Individuals With and Without Diabetes Mellitus | Archives of Internal Medicine | 2005 | 710 |
| 39 | Smoking cessation support delivered via mobile phone text messaging (txt2stop): a single-blind, randomised trial | Lancet, The | 2011 | 674 |
| 40 | Blood Pressure Lowering in Type 2 Diabetes | JAMA - Journal of the American Medical Association | 2015 | 673 |
| 41 | A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension | Lancet, The | 2016 | 670 |
| 42 | Risk prediction models: I. Development, internal validation, and assessing the incremental value of a new (bio)marker | Heart | 2012 | 666 |
| 43 | Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis | The Lancet Global Health | 2019 | 662 |
| 44 | Exercise to prevent falls in older adults: an updated systematic review and meta-analysis | British Journal of Sports Medicine | 2017 | 656 |
| 45 | Hypertension | Nature Reviews Disease Primers | 2018 | 636 |
| 46 | Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data | Lancet Diabetes and Endocrinology,the | 2015 | 604 |
| 47 | Exercise to prevent falls in older adults: an updated meta-analysis and best practice recommendations | NSW Public Health Bulletin | 2011 | 603 |
| 48 | SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis | Lancet Diabetes and Endocrinology,the | 2019 | 595 |
| 49 | Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery | JAMA - Journal of the American Medical Association | 2017 | 579 |
| 50 | Effect of Lifestyle-Focused Text Messaging on Risk Factor Modification in Patients With Coronary Heart Disease | JAMA - Journal of the American Medical Association | 2015 | 561 |
