| # | Title | Journal | Year | Citations |
|---|
| 1 | A new coronavirus associated with human respiratory disease in China | Nature | 2020 | 9,370 |
| 2 | Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle | Journal of Medical Virology | 2020 | 2,395 |
| 3 | Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 | Nature Medicine | 2020 | 2,083 |
| 4 | Human neutralizing antibodies elicited by SARS-CoV-2 infection | Nature | 2020 | 1,524 |
| 5 | Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia | Radiology | 2020 | 997 |
| 6 | Drug treatment options for the 2019-new coronavirus (2019-nCoV) | BioScience Trends | 2020 | 852 |
| 7 | Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses | Biochemical and Biophysical Research Communications | 2020 | 758 |
| 8 | Viral and host factors related to the clinical outcome of COVID-19 | Nature | 2020 | 746 |
| 9 | COVID-19 with Different Severities: A Multicenter Study of Clinical Features | American Journal of Respiratory and Critical Care Medicine | 2020 | 690 |
| 10 | Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients | Chinese Medical Journal | 2020 | 686 |
| 11 | A living WHO guideline on drugs for covid-19 | BMJ, The | 2020 | 664 |
| 12 | Clinical Features of COVID-19-Related Liver Functional Abnormality | Clinical Gastroenterology and Hepatology | 2020 | 628 |
| 13 | Clinical progression of patients with COVID-19 in Shanghai, China | Journal of Infection | 2020 | 627 |
| 14 | The evolutionary history of vertebrate RNA viruses | Nature | 2018 | 596 |
| 15 | Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection | Nature | 2016 | 514 |
| 16 | COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas | Cell | 2021 | 512 |
| 17 | Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity | Nature Immunology | 2013 | 464 |
| 18 | Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment | BioScience Trends | 2020 | 425 |
| 19 | Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies | Cellular and Molecular Immunology | 2020 | 413 |
| 20 | Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients | Cell | 2020 | 405 |
| 21 | METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer | Molecular Cancer | 2019 | 389 |
| 22 | Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1 | Hepatology | 2016 | 332 |
| 23 | Association between age and clinical characteristics and outcomes of COVID-19 | European Respiratory Journal | 2020 | 316 |
| 24 | Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance | Lancet, The | 2013 | 308 |
| 25 | Clinical observation and management of COVID-19 patients | Emerging Microbes and Infections | 2020 | 306 |
| 26 | Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: A mixed-method study | Brain, Behavior, and Immunity | 2020 | 303 |
| 27 | Dual-Sampling Attention Network for Diagnosis of COVID-19 From Community Acquired Pneumonia | IEEE Transactions on Medical Imaging | 2020 | 293 |
| 28 | Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis | Med | 2021 | 252 |
| 29 | Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition) | Annals of Translational Medicine | 2020 | 252 |
| 30 | Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 250 |
| 31 | Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activation | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 246 |
| 32 | Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells | Nature Communications | 2015 | 241 |
| 33 | Large-scale screening to distinguish between COVID-19 and community-acquired pneumonia using infection size-aware classification | Physics in Medicine and Biology | 2021 | 233 |
| 34 | Using Metagenomics to Characterize an Expanding Virosphere | Cell | 2018 | 219 |
| 35 | Evaluating the Association of Clinical Characteristics With Neutralizing Antibody Levels in Patients Who Have Recovered From Mild COVID-19 in Shanghai, China | JAMA Internal Medicine | 2020 | 211 |
| 36 | The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing | Cell Discovery | 2020 | 188 |
| 37 | A Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2 | International Journal of Molecular Sciences | 2020 | 186 |
| 38 | Shorter durations and lower doses of peginterferon alfa-2a are associated with inferior hepatitis B e antigen seroconversion rates in hepatitis B virus genotypes B or C | Hepatology | 2011 | 183 |
| 39 | Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes | Nature Methods | 2021 | 182 |
| 40 | One-step rapid quantification of SARS-CoV-2 virus particles via low-cost nanoplasmonic sensors in generic microplate reader and point-of-care device | Biosensors and Bioelectronics | 2021 | 181 |
| 41 | Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKϵ and DDX3 | Journal of General Virology | 2010 | 173 |
| 42 | HBsAg inhibits TLR9-mediated activation and IFN-α production in plasmacytoid dendritic cells | Molecular Immunology | 2009 | 167 |
| 43 | Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 166 |
| 44 | CT quantification of pneumonia lesions in early days predicts progression to severe illness in a cohort of COVID-19 patients | Theranostics | 2020 | 166 |
| 45 | Abnormal lung quantification in chest CT images of COVID‐19 patients with deep learning and its application to severity prediction | Medical Physics | 2021 | 154 |
| 46 | Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples | Nature Biomedical Engineering | 2022 | 153 |
| 47 | Adaptive Feature Selection Guided Deep Forest for COVID-19 Classification With Chest CT | IEEE Journal of Biomedical and Health Informatics | 2020 | 149 |
| 48 | Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection | Cell Reports | 2020 | 148 |
| 49 | Long-term functional maintenance of primary human hepatocytes in vitro | Science | 2019 | 147 |
| 50 | High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection | Journal of Infectious Diseases | 2018 | 144 |
