| # | Title | Journal | Year | Citations |
|---|
| 1 | Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial | Lancet Oncology, The | 2013 | 1,017 |
| 2 | Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study | Lancet Oncology, The | 2019 | 773 |
| 3 | Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial | Lancet, The | 2016 | 505 |
| 4 | Local Treatment of Unresectable Colorectal Liver Metastases: Results of a Randomized Phase II Trial | Journal of the National Cancer Institute | 2017 | 466 |
| 5 | The Oncosurgery Approach to Managing Liver Metastases from Colorectal Cancer: A Multidisciplinary International Consensus | Oncologist | 2012 | 453 |
| 6 | Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation | JAMA - Journal of the American Medical Association | 2017 | 443 |
| 7 | 2018 update of the EULAR recommendations for the management of Behçet’s syndrome | Annals of the Rheumatic Diseases | 2018 | 442 |
| 8 | Managing synchronous liver metastases from colorectal cancer: A multidisciplinary international consensus | Cancer Treatment Reviews | 2015 | 430 |
| 9 | Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases: a randomized EORTC Intergroup phase II study (EORTC 40004) | Annals of Oncology | 2012 | 370 |
| 10 | Sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma (TACE 2): a randomised placebo-controlled, double-blind, phase 3 trial | The Lancet Gastroenterology and Hepatology | 2017 | 362 |
| 11 | Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trial | Lancet Respiratory Medicine,the | 2016 | 349 |
| 12 | BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults | Thorax | 2016 | 280 |
| 13 | One-year treatment of obesity: a randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor | International Journal of Obesity | 2000 | 268 |
| 14 | Cardiac arrhythmia and nocturnal hypoglycaemia in type 1 diabetes—the ‘dead in bed’ syndrome revisited | Diabetologia | 2009 | 259 |
| 15 | Randomized clinical trial of prehabilitation before planned liver resection | British Journal of Surgery | 2016 | 242 |
| 16 | British Thoracic Society guidelines for home oxygen use in adults: accredited by NICE | Thorax | 2015 | 236 |
| 17 | Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate) | Annals of the Rheumatic Diseases | 2018 | 236 |
| 18 | Prevention and treatment of diabetic foot ulcers | Journal of the Royal Society of Medicine | 2017 | 232 |
| 19 | Tuberculosis and poverty. | BMJ: British Medical Journal | 1993 | 228 |
| 20 | The evolution of cancer surgery and future perspectives | Nature Reviews Clinical Oncology | 2015 | 226 |
| 21 | Radiofrequency Ablation and Endoscopic Mucosal Resection for Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma: Outcomes of the UK National Halo RFA Registry | Gastroenterology | 2013 | 223 |
| 22 | New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes | PLoS Genetics | 2012 | 216 |
| 23 | The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis | International Journal of Rheumatology | 2011 | 200 |
| 24 | Randomized Controlled Trial of Rituximab and Cost‐Effectiveness Analysis in Treating Fatigue and Oral Dryness in Primary Sjögren's Syndrome | Arthritis and Rheumatology | 2017 | 194 |
| 25 | A Common and Recurrent 13-bp Deletion in the Autoimmune Regulator Gene in British Kindreds with Autoimmune Polyendocrinopathy Type 1 | American Journal of Human Genetics | 1998 | 188 |
| 26 | RAS Mutation Clinical Risk Score to Predict Survival After Resection of Colorectal Liver Metastases | Annals of Surgery | 2019 | 167 |
| 27 | Meta-analysis of closure of the fascial defect during laparoscopic incisional and ventral hernia repair | British Journal of Surgery | 2016 | 153 |
| 28 | Phenotypes of organ involvement in sarcoidosis | European Respiratory Journal | 2018 | 146 |
| 29 | N-Acetylcysteine treatment to prevent the progression of multisystem organ failure | Critical Care Medicine | 1999 | 142 |
| 30 | Predicting Outcomes in Idiopathic Pulmonary Fibrosis Using Automated Computed Tomographic Analysis | American Journal of Respiratory and Critical Care Medicine | 2018 | 140 |
| 31 | Caught in a Trap? Proteomic Analysis of Neutrophil Extracellular Traps in Rheumatoid Arthritis and Systemic Lupus Erythematosus | Frontiers in Immunology | 2019 | 136 |
| 32 | Bronchodilator reversibility, exercise performance and breathlessness in stable chronic obstructive pulmonary disease | European Respiratory Journal | 1992 | 135 |
| 33 | Peripheral blood eosinophil counts and bronchial responsiveness. | Thorax | 1987 | 134 |
| 34 | Effect of specialist decision-making on treatment strategies for colorectal liver metastases | British Journal of Surgery | 2012 | 127 |
| 35 | Inflammation and cancer: What a surgical oncologist should know | European Journal of Surgical Oncology | 2018 | 127 |
| 36 | Diagnostic and therapeutic utility of single-operator peroral cholangioscopy for indeterminate biliary lesions and bile duct stones | European Journal of Gastroenterology and Hepatology | 2012 | 118 |
| 37 | Cryptogenic fibrosing alveolitis with preserved lung volumes | Thorax | 1997 | 117 |
| 38 | The clinical determinants of malignant transformation in oral epithelial dysplasia | Oral Oncology | 2012 | 117 |
| 39 | Correlation between blood loss and inferior vena caval pressure during liver resection | British Journal of Surgery | 2003 | 114 |
| 40 | Specific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer | British Journal of Cancer | 2017 | 114 |
| 41 | Fear of recurrence and possible cases of anxiety and depression in orofacial cancer patients | International Journal of Oral and Maxillofacial Surgery | 2003 | 113 |
| 42 | D2 gastrectomy: Lessons from a prospective audit of the learning curve | British Journal of Surgery | 2005 | 110 |
| 43 | Management of tumors arising from the parapharyngeal space: A systematic review of 1,293 cases reported over 25 years | Laryngoscope | 2015 | 107 |
| 44 | Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS) | Annals of the Rheumatic Diseases | 2017 | 107 |
| 45 | Etanercept for the treatment of rheumatoid arthritis | Immunotherapy | 2018 | 107 |
| 46 | Ventilation and Breathing Pattern during Sleep in Duchenne Muscular Dystrophy | Chest | 1989 | 106 |
| 47 | Bronchodilator reversibility, exercise performance and breathlessness in stable chronic obstructive pulmonary disease | European Respiratory Journal | 1992 | 105 |
| 48 | A population study of imatinib in chronic myeloid leukaemia demonstrates lower efficacy than in clinical trials | Leukemia | 2008 | 97 |
| 49 | After treat-to-target: can a targeted ultrasound initiative improve RA outcomes?: Table 1 | Annals of the Rheumatic Diseases | 2012 | 97 |
| 50 | The effect of the orally active platelet-activating factor antagonist WEB 2086 in the treatment of asthma. | American Journal of Respiratory and Critical Care Medicine | 1994 | 96 |
