| # | Title | Journal | Year | Citations |
|---|
| 1 | Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma | New England Journal of Medicine | 2015 | 6,773 |
| 2 | Common variants conferring risk of schizophrenia | Nature | 2009 | 1,572 |
| 3 | Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial | Lancet Oncology, The | 2017 | 1,388 |
| 4 | How mental health care should change as a consequence of the COVID-19 pandemic | Lancet Psychiatry,the | 2020 | 1,101 |
| 5 | Classification of the cutaneous manifestations of COVID ‐19: a rapid prospective nationwide consensus study in Spain with 375 cases | British Journal of Dermatology | 2020 | 1,030 |
| 6 | Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice | European Journal of Echocardiography | 2009 | 890 |
| 7 | European Society of Hypertension practice guidelines for ambulatory blood pressure monitoring | Journal of Hypertension | 2014 | 758 |
| 8 | Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study | Lancet Oncology, The | 2015 | 753 |
| 9 | Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib | JAMA Oncology | 2020 | 746 |
| 10 | A Randomized and Prospective Study of 3 Procedures for the Diagnosis of Catheter-Related Bloodstream Infection without Catheter Withdrawal | Clinical Infectious Diseases | 2007 | 744 |
| 11 | Recommendations on the Echocardiographic Assessment of Aortic Valve Stenosis: A Focused Update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography | Journal of the American Society of Echocardiography | 2017 | 729 |
| 12 | Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk | Clinical Journal of the American Society of Nephrology: CJASN | 2010 | 670 |
| 13 | Continuous Aspiration of Subglottic Secretions in the Prevention of Ventilator-Associated Pneumonia in the Postoperative Period of Major Heart Surgery | Chest | 2008 | 642 |
| 14 | Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis | Cell | 2011 | 603 |
| 15 | Trends in Length of Stay and Short-term Outcomes Among Medicare Patients Hospitalized for Heart Failure, 1993-2006 | JAMA - Journal of the American Medical Association | 2010 | 596 |
| 16 | National Trends in the Outpatient Diagnosis and Treatment of Bipolar Disorder in Youth | Archives of General Psychiatry | 2007 | 595 |
| 17 | Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial | Lancet Oncology, The | 2017 | 561 |
| 18 | ESPEN guidelines on chronic intestinal failure in adults | Clinical Nutrition | 2016 | 554 |
| 19 | Atezolizumab with or without chemotherapy in metastatic urothelial cancer (IMvigor130): a multicentre, randomised, placebo-controlled phase 3 trial | Lancet, The | 2020 | 546 |
| 20 | The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study | Lancet Psychiatry,the | 2019 | 528 |
| 21 | Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data | Lancet Respiratory Medicine,the | 2014 | 527 |
| 22 | Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group | Molecular Psychiatry | 2018 | 522 |
| 23 | Genome-wide Analyses Identify KIF5A as a Novel ALS Gene | Neuron | 2018 | 517 |
| 24 | EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis | Annals of the Rheumatic Diseases | 2013 | 504 |
| 25 | The second Euro Heart Survey on acute coronary syndromes: characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004 | European Heart Journal | 2006 | 496 |
| 26 | Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease | Kidney International | 2008 | 491 |
| 27 | Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2−, Node-Positive, High-Risk, Early Breast Cancer (monarchE) | Journal of Clinical Oncology | 2020 | 478 |
| 28 | ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults | Clinical Nutrition | 2015 | 473 |
| 29 | Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography | European Heart Journal Cardiovascular Imaging | 2017 | 469 |
| 30 | 2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer | Lancet Oncology, The | 2019 | 458 |
| 31 | Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: The RELIEF trial | Hepatology | 2013 | 452 |
| 32 | Efficacy of a Comprehensive Geriatric Intervention in Older Patients Hospitalized for Hip Fracture: A Randomized, Controlled Trial | Journal of the American Geriatrics Society | 2005 | 448 |
| 33 | Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma | Journal of Clinical Oncology | 2022 | 446 |
| 34 | Quality of life in end-stage renal disease patients | American Journal of Kidney Diseases | 2001 | 422 |
| 35 | Saccharomyces cerevisiae Fungemia: An Emerging Infectious Disease | Clinical Infectious Diseases | 2005 | 408 |
| 36 | EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice | Annals of the Rheumatic Diseases | 2015 | 402 |
| 37 | Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain | Critical Care | 2009 | 399 |
| 38 | European Resuscitation Council Guidelines for Resuscitation 2015 | Resuscitation | 2015 | 397 |
| 39 | Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Peritoneal Surface Malignancies of Colonic Origin: A Consensus Statement | Annals of Surgical Oncology | 2007 | 390 |
| 40 | Preventive strategies for mental health | Lancet Psychiatry,the | 2018 | 390 |
| 41 | ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others | Clinical Microbiology and Infection | 2014 | 383 |
| 42 | Simvastatin Lowers Portal Pressure in Patients With Cirrhosis and Portal Hypertension: A Randomized Controlled Trial | Gastroenterology | 2009 | 372 |
| 43 | The impact of COVID-19 lockdown on child and adolescent mental health: systematic review | European Child and Adolescent Psychiatry | 2023 | 364 |
| 44 | The role of tumour necrosis factor, interleukin 6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the nervous system | Progress in Neurobiology | 1998 | 358 |
| 45 | A Histologic Scoring System for Prognosis of Patients With Alcoholic Hepatitis | Gastroenterology | 2014 | 353 |
| 46 | 3D bioprinting of functional human skin: production and in vivo analysis | Biofabrication | 2017 | 329 |
| 47 | European Resuscitation Council Guidelines for Resuscitation 2010 Section 6. Paediatric life support | Resuscitation | 2010 | 324 |
| 48 | Real-time dominant frequency mapping and ablation of dominant frequency sites in atrial fibrillation with left-to-right frequency gradients predicts long-term maintenance of sinus rhythm | Heart Rhythm | 2009 | 319 |
| 49 | Mycobacterium tuberculosis Infection in Recipients of Solid Organ Transplants | Clinical Infectious Diseases | 2005 | 318 |
| 50 | Folate Receptor β Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages | Cancer Research | 2009 | 317 |
