# | Title | Journal | Year | Citations |
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1 | Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors | Nature | 1992 | 1,678 |
2 | Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers | Science | 2000 | 1,206 |
3 | Identification of a nuclear receptor that is activated by farnesol metabolites | Cell | 1995 | 1,060 |
4 | The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene | Journal of Biological Chemistry | 1997 | 1,034 |
5 | Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. | Molecular Endocrinology | 1993 | 698 |
6 | Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists | Nature | 1997 | 586 |
7 | Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice | Nature Medicine | 1998 | 568 |
8 | RAR and RXR modulation in cancer and metabolic disease | Nature Reviews Drug Discovery | 2007 | 450 |
9 | Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (Rxr)/Peroxisome Proliferator–Activated Receptor γ (Pparγ) Heterodimer | Journal of Experimental Medicine | 2001 | 416 |
10 | Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. | Proceedings of the National Academy of Sciences of the United States of America | 1995 | 397 |
11 | The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. | Molecular and Cellular Biology | 1994 | 317 |
12 | Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators | Journal of Steroid Biochemistry and Molecular Biology | 1994 | 258 |
13 | Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist | Stem Cells | 2009 | 243 |
14 | Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor | Blood | 1994 | 222 |
15 | Efficacy and Safety of a Once-Daily Morphine Formulation in Chronic, Moderate-to-Severe Osteoarthritis Pain | Journal of Pain and Symptom Management | 2002 | 206 |
16 | Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation | | 1997 | 205 |
17 | RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. | Journal of Biological Chemistry | 1994 | 191 |
18 | Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 183 |
19 | Orphan nuclear receptor estrogen-related receptor is essential for adaptive thermogenesis | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 179 |
20 | Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist | Experimental Hematology | 2005 | 176 |
21 | Transactivation by Retinoid X Receptor–Peroxisome Proliferator-Activated Receptor γ (PPARγ) Heterodimers: Intermolecular Synergy Requires Only the PPARγ Hormone-Dependent Activation Function | Molecular and Cellular Biology | 1998 | 172 |
22 | Activation of specific RXR heterodimers by an antagonist of RXR homodimers | Nature | 1996 | 165 |
23 | The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional acitivity | Journal of Steroid Biochemistry and Molecular Biology | 1994 | 150 |
24 | A Small, Nonpeptidyl Mimic of Granulocyte-Colony- Stimulating Factor | | 1998 | 148 |
25 | Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes | Blood | 1996 | 147 |
26 | C5a-mediated release of interleukin 6 by human monocytes | Clinical Immunology and Immunopathology | 1990 | 141 |
27 | Distribution patterns of estrogen receptor α and β in the human cortex and hippocampus during development and adulthood | Journal of Comparative Neurology | 2007 | 139 |
28 | RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism | Journal of Biological Chemistry | 1994 | 136 |
29 | An Orally Active Selective Androgen Receptor Modulator Is Efficacious on Bone, Muscle, and Sex Function with Reduced Impact on Prostate | Endocrinology | 2007 | 125 |
30 | Retinoid-X receptor signalling in the developing spinal cord | Nature | 1998 | 122 |
31 | Biological Correlates of Acute Hypersensitivity Events with DAB389IL-2 (Denileukin Diftitox, ONTAK®) in Cutaneous T-Cell Lymphoma: Decreased Frequency and Severity with Steroid Premedication | Clinical Lymphoma and Myeloma | 2001 | 121 |
32 | Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-γ and altered expression of Bcl-2/Bax | British Journal of Cancer | 2002 | 118 |
33 | Retinoid-induced apoptosis in normal and neoplastic tissues | Cell Death and Differentiation | 1998 | 112 |
34 | Novel retinoic acid receptor ligands in Xenopus embryos. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 111 |
35 | Peroxisome Proliferator-Activated Receptor (PPAR) γ and Retinoid X Receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle | Diabetologia | 2001 | 106 |
36 | The A and B Isoforms of the Human Progesterone Receptor Operate through Distinct Signaling Pathways within Target Cells | Molecular and Cellular Biology | 1994 | 104 |
37 | Phase III Vehicle-Controlled, Multi-Centered Study of Topical Alitretinoin Gel 0.1% in Cutaneous AIDS-Related Kaposi??s Sarcoma | American Journal of Clinical Dermatology | 2001 | 89 |
38 | Pharmaceutical intervention in the JAK/STAT signaling pathway | Oncogene | 2000 | 86 |
39 | Results of a Phase II trial of oral bexarotene (Targretin) combined with interferon alfa-2b (Intron-A) for patients with cutaneous T-cell lymphoma | Cancer | 2007 | 82 |
40 | The Human Peroxisome Proliferator-activated Receptor (PPAR) Subtype NUC1 Represses the Activation of hPPARα and Thyroid Hormone Receptors | Journal of Biological Chemistry | 1995 | 80 |
41 | Interaction of glucocorticoid analogues with the human glucocorticoid receptor | Journal of Steroid Biochemistry and Molecular Biology | 1992 | 75 |
42 | Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein protein interaction profile | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 74 |
43 | 1,25-Dihydroxyvitamin D3 modulates phosphorylation of serine 205 in the human vitamin D receptor: site-directed mutagenesis of this residue promotes alternative phosphorylation | Biochemistry | 1994 | 72 |
44 | Androgen Receptor-Mediated Antagonism of Estrogen-Dependent Low Density Lipoprotein Receptor Transcription in Cultured Hepatocytes | Endocrinology | 1997 | 72 |
45 | Discovery of 6-N,N-Bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a Novel Selective Androgen Receptor Modulator# | Journal of Medicinal Chemistry | 2006 | 71 |
46 | Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes | Journal of Molecular Biology | 2000 | 69 |
47 | Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells. | Molecular Endocrinology | 1994 | 67 |
48 | Transcriptional activation and dimerization functions in the human vitamin D receptor. | Molecular Endocrinology | 1996 | 65 |
49 | 5-Benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as Selective Progesterone Receptor Modulators | Journal of Medicinal Chemistry | 2003 | 65 |
50 | Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor | Blood | 1994 | 64 |