| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 | Science | 2020 | 1,749 |
| 3 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 4 | COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study | The Lancet Child and Adolescent Health | 2020 | 978 |
| 5 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 929 |
| 6 | A microbial signature for Crohn's disease | Gut | 2017 | 657 |
| 7 | Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa | Nature Genetics | 2019 | 641 |
| 8 | Towards standards for human fecal sample processing in metagenomic studies | Nature Biotechnology | 2017 | 581 |
| 9 | Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's disease | EMBO Molecular Medicine | 2012 | 501 |
| 10 | Analytical Methods in Untargeted Metabolomics: State of the Art in 2015 | Frontiers in Bioengineering and Biotechnology | 2015 | 495 |
| 11 | An Index Combining Respiratory Rate and Oxygenation to Predict Outcome of Nasal High-Flow Therapy | American Journal of Respiratory and Critical Care Medicine | 2019 | 477 |
| 12 | PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab | Cancer Research | 2008 | 435 |
| 13 | Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations | Lancet Neurology, The | 2015 | 393 |
| 14 | Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity | Oncogene | 2009 | 385 |
| 15 | Neurodegeneration in diabetic retinopathy: does it really matter? | Diabetologia | 2018 | 358 |
| 16 | Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths | Science Immunology | 2021 | 357 |
| 17 | Predicting success of high-flow nasal cannula in pneumonia patients with hypoxemic respiratory failure: The utility of the ROX index | Journal of Critical Care | 2016 | 302 |
| 18 | Genome-wide association analysis identifies susceptibility loci for migraine without aura | Nature Genetics | 2012 | 294 |
| 19 | Short-Term Effect of Antibiotics on Human Gut Microbiota | PLoS ONE | 2014 | 272 |
| 20 | Lysosomal impairment in Parkinson's disease | Movement Disorders | 2013 | 270 |
| 21 | Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome | Scientific Reports | 2015 | 248 |
| 22 | Guidelines of the International Headache Society for controlled trials of preventive treatment of chronic migraine in adults | Cephalalgia | 2018 | 245 |
| 23 | Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data | Lancet Neurology, The | 2018 | 229 |
| 24 | A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study | Intensive Care Medicine | 2018 | 226 |
| 25 | Rivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome | Annals of Internal Medicine | 2019 | 203 |
| 26 | The microbiome in respiratory medicine: current challenges and future perspectives | European Respiratory Journal | 2017 | 194 |
| 27 | HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21 | Molecular Biology of the Cell | 2008 | 188 |
| 28 | Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial | Lancet Neurology, The | 2017 | 176 |
| 29 | Consensus statement for diagnosis of subcortical small vessel disease | Journal of Cerebral Blood Flow and Metabolism | 2016 | 173 |
| 30 | Semaglutide, reduction in glycated haemoglobin and the risk of diabetic retinopathy | Diabetes, Obesity and Metabolism | 2018 | 173 |
| 31 | Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review | Autoimmunity Reviews | 2020 | 173 |
| 32 | Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution | Cephalalgia | 2020 | 158 |
| 33 | A photoconvertible fluorescent reporter to track chaperone-mediated autophagy | Nature Communications | 2011 | 156 |
| 34 | Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure | Critical Care | 2016 | 150 |
| 35 | Increased mortality associated with meticillin-resistant Staphylococcus aureus (MRSA) infection in the Intensive Care Unit: results from the EPIC II study | International Journal of Antimicrobial Agents | 2011 | 145 |
| 36 | Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis | Lancet, The | 2022 | 144 |
| 37 | Impact of blood pressure changes and course on hematoma growth in acute intracerebral hemorrhage | European Journal of Neurology | 2013 | 142 |
| 38 | Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial | Lancet, The | 2012 | 138 |
| 39 | Neural Responses to Visual Food Cues: Insights from Functional Magnetic Resonance Imaging | European Eating Disorders Review | 2013 | 138 |
| 40 | Processing faecal samples: a step forward for standards in microbial community analysis | BMC Microbiology | 2014 | 134 |
| 41 | Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration | 2020 | 133 |
| 42 | Diabetic Retinopathy in the Context of Patients with Diabetes | Ophthalmic Research | 2019 | 130 |
| 43 | Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs | Seminars in Arthritis and Rheumatism | 2020 | 129 |
| 44 | The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments) | Journal of Cerebral Blood Flow and Metabolism | 2017 | 128 |
| 45 | Cognitive impairment and dementia: a new emerging complication of type 2 diabetes—The diabetologist’s perspective | Acta Diabetologica | 2017 | 127 |
| 46 | Admission CT perfusion may overestimate initial infarct core: the ghost infarct core concept | Journal of NeuroInterventional Surgery | 2017 | 126 |
| 47 | A care bundle approach for prevention of ventilator-associated pneumonia | Clinical Microbiology and Infection | 2013 | 119 |
| 48 | Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis | JAMA Neurology | 2019 | 119 |
| 49 | Protein Arginine Methyltransferase 5 Regulates ERK1/2 Signal Transduction Amplitude and Cell Fate Through CRAF | Science Signaling | 2011 | 118 |
| 50 | Cell Cycle Control and HIV-1 Susceptibility Are Linked by CDK6-Dependent CDK2 Phosphorylation of SAMHD1 in Myeloid and Lymphoid Cells | Journal of Immunology | 2014 | 118 |
