| # | Title | Journal | Year | Citations |
|---|
| 1 | Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis | Lancet Oncology, The | 2016 | 592 |
| 2 | Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2×2 factorial trial | Lancet Oncology, The | 2013 | 580 |
| 3 | Chemoradiotherapy with or without cetuximab in patients with oesophageal cancer (SCOPE1): a multicentre, phase 2/3 randomised trial | Lancet Oncology, The | 2013 | 346 |
| 4 | Antenatal betamethasone and incidence of neonatal respiratory distress after elective caesarean section: pragmatic randomised trial | BMJ: British Medical Journal | 2005 | 314 |
| 5 | Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial | Lancet Oncology, The | 2014 | 296 |
| 6 | Risk and incidence of dementia in a cohort of older subjects with Parkinson's disease in the United Kingdom | Movement Disorders | 2004 | 281 |
| 7 | Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial | Lancet Oncology, The | 2014 | 270 |
| 8 | Systematic Review and Meta-Regression of Factors Affecting Midline Incisional Hernia Rates: Analysis of 14 618 Patients | PLoS ONE | 2015 | 254 |
| 9 | Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk | PLoS Genetics | 2013 | 244 |
| 10 | Gemcitabine alone or in combination with cisplatin in patients with advanced or metastatic cholangiocarcinomas or other biliary tract tumours: a multicentre randomised phase II study – The UK ABC-01 Study | British Journal of Cancer | 2009 | 243 |
| 11 | Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial | Lancet Oncology, The | 2011 | 232 |
| 12 | Recommendations for Management of Diabetes During Ramadan | Diabetes Care | 2005 | 226 |
| 13 | Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care: systematic review and network meta-analysis | BMJ, The | 2014 | 225 |
| 14 | Accuracy of diagnosis in patients with presumed Parkinson's disease | Age and Ageing | 1999 | 224 |
| 15 | Epidemiological aspects of human cryptosporidiosis | Epidemiology and Infection | 1990 | 202 |
| 16 | Molecular characterisation of SMARCB1 and NF2 in familial and sporadic schwannomatosis | Journal of Medical Genetics | 2008 | 179 |
| 17 | Coffin-Siris Syndrome and the BAF Complex: Genotype-Phenotype Study in 63 Patients | Human Mutation | 2013 | 178 |
| 18 | Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX-4) as second-line therapy in metastatic colorectal cancer: a randomized phase III noninferiority study | Annals of Oncology | 2008 | 163 |
| 19 | An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy | Nature Genetics | 2013 | 151 |
| 20 | National Glycopeptide-Resistant Enterococcal Bacteraemia Surveillance Working Group Report to the Department of Health — August 2004 | Journal of Hospital Infection | 2006 | 147 |
| 21 | Use of the GDS-15 geriatric depression scale as a screening instrument for depressive symptomatology in patients with Parkinson's disease and their carers in the community | Age and Ageing | 1999 | 141 |
| 22 | Measuring the impact of Parkinson's disease with the Parkinson's Disease Quality of Life questionnaire | Age and Ageing | 1999 | 133 |
| 23 | 3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial | Lancet Oncology, The | 2018 | 133 |
| 24 | The Cockayne Syndrome Natural History (CoSyNH) study: clinical findings in 102 individuals and recommendations for care | Genetics in Medicine | 2016 | 127 |
| 25 | ACP Broadsheet 128: June 1991. Laboratory methods for diagnosing cryptosporidiosis. | Journal of Clinical Pathology | 1991 | 126 |
| 26 | Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis | The Lancet Gastroenterology and Hepatology | 2018 | 125 |
| 27 | Short-course versus prolonged-course antibiotic therapy for hospital-acquired pneumonia in critically ill adults | The Cochrane Library | 2015 | 122 |
| 28 | EXTRA—A Multicenter Phase II Study of Chemoradiation Using a 5 Day per Week Oral Regimen of Capecitabine and Intravenous Mitomycin C in Anal Cancer | International Journal of Radiation Oncology Biology Physics | 2008 | 120 |
| 29 | Behavioural, educational and respiratory outcomes of antenatal betamethasone for term caesarean section (ASTECS trial) | Archives of Disease in Childhood: Fetal and Neonatal Edition | 2013 | 116 |
| 30 | Mild cognitive impairment in Parkinson's disease and its progression onto dementia: a 16‐year outcome evaluation of the Denbighshire cohort | International Journal of Geriatric Psychiatry | 2015 | 108 |
| 31 | Comparison of the symptoms of exercise-induced muscle damage after an initial and repeated bout of plyometric exercise in men and boys | Journal of Applied Physiology | 2005 | 105 |
| 32 | Evaluation of pre-analytical factors affecting plasma DNA analysis | Scientific Reports | 2018 | 102 |
| 33 | Clinical practice guideline on peri- and postoperative care of arteriovenous fistulas and grafts for haemodialysis in adults | Nephrology Dialysis Transplantation | 2019 | 94 |
| 34 | Does gum chewing reduce postoperative ileus following open colectomy for left-sided colon and rectal cancer? - a prospective randomized controlled trial | Colorectal Disease | 2006 | 93 |
| 35 | Self-reported benefits from successive bilateral cochlear implantation in post-lingually deafened adults: randomised controlled trial | International Journal of Audiology | 2006 | 92 |
| 36 | Monitoring the effectiveness of cleaning in four British hospitals | American Journal of Infection Control | 2007 | 90 |
| 37 | The Parkinson's Disease Activities of Daily Living Scale: a new simple and brief subjective measure of disability in Parkinson's disease | Clinical Rehabilitation | 2001 | 88 |
| 38 | British Association of Dermatologists’ guidelines for the safe and effective prescribing of methotrexate for skin disease 2016 | British Journal of Dermatology | 2016 | 86 |
| 39 | Mutations in the GlyT2 Gene (SLC6A5) Are a Second Major Cause of Startle Disease | Journal of Biological Chemistry | 2012 | 84 |
| 40 | Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery | British Journal of Surgery | 2014 | 81 |
| 41 | Maternal and neonatal side-effects of remifentanil patient-controlled analgesia in labour | British Journal of Anaesthesia | 2005 | 80 |
| 42 | The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin–Siris syndrome | Genetics in Medicine | 2019 | 80 |
| 43 | Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions | JAMA - Journal of the American Medical Association | 2020 | 79 |
| 44 | Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Multidisciplinary Management | Colorectal Disease | 2017 | 77 |
| 45 | Feasibility and reliability of frailty assessment in the critically ill: a systematic review | Critical Care | 2018 | 76 |
| 46 | Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 | Breast Cancer Research | 2011 | 71 |
| 47 | Magnetic resonance imaging in rectal cancer downstaged using neoadjuvant chemoradiation: accuracy of prediction of tumour stage and circumferential resection margin status | Colorectal Disease | 2008 | 69 |
| 48 | Vildagliptin therapy and hypoglycaemia in Muslim type 2 diabetes patients during Ramadan | International Journal of Clinical Practice | 2009 | 68 |
| 49 | Prospective evaluation of a selective approach to cholangiography for suspected common bile duct stones | Annals of the Royal College of Surgeons of England | 2010 | 68 |
| 50 | Serum C-reactive protein as a prognostic indicator in patients with oral squamous cell carcinoma | Oral Oncology | 2009 | 67 |
