| # | Title | Journal | Year | Citations |
|---|
| 1 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 2 | Variability of Blood Glucose Concentration and Short-term Mortality in Critically Ill Patients | Anesthesiology | 2006 | 1,305 |
| 3 | The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain | Emergency Medicine Journal | 2001 | 741 |
| 4 | A Comparison of Omeprazole with Ranitidine for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs | New England Journal of Medicine | 1998 | 723 |
| 5 | Cardiopulmonary Exercise Testing as a Screening Test for Perioperative Management of Major Surgery in the Elderly | Chest | 1999 | 546 |
| 6 | Does the Clinically Significant Difference in Visual Analog Scale Pain Scores Vary with Gender, Age, or Cause of Pain? | Academic Emergency Medicine | 1998 | 534 |
| 7 | A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 | Nature Genetics | 2008 | 514 |
| 8 | Factors influencing outcome following mild traumatic brain injury in adults | Journal of the International Neuropsychological Society | 2000 | 494 |
| 9 | Crohn's disease management after intestinal resection: a randomised trial | Lancet, The | 2015 | 475 |
| 10 | Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice | Nature Medicine | 2002 | 433 |
| 11 | Hypoglycemia and Outcome in Critically Ill Patients | Mayo Clinic Proceedings | 2010 | 378 |
| 12 | Targeted exercise against osteoporosis: A systematic review and meta-analysis for optimising bone strength throughout life | BMC Medicine | 2010 | 350 |
| 13 | Preoperative Evaluation of Cardiac Failure and Ischemia in Elderly Patients by Cardiopulmonary Exercise Testing | Chest | 1993 | 328 |
| 14 | Osteoporosis in Men | New England Journal of Medicine | 2008 | 305 |
| 15 | Impact of Early Intervention on Outcome After Mild Traumatic Brain Injury in Children | Pediatrics | 2001 | 296 |
| 16 | First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials | Lancet Oncology, The | 2017 | 293 |
| 17 | Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium | JAMA - Journal of the American Medical Association | 2016 | 289 |
| 18 | The Keystone Design Perforator Island Flap in reconstructive surgery | ANZ Journal of Surgery | 2003 | 284 |
| 19 | Overall Survival Improvement in Patients with Lung Cancer and Bone Metastases Treated with Denosumab Versus Zoledronic Acid: Subgroup Analysis from a Randomized Phase 3 Study | Journal of Thoracic Oncology | 2012 | 281 |
| 20 | Determining the minimum clinically significant difference in visual analog pain score for children | Annals of Emergency Medicine | 2001 | 274 |
| 21 | Acceptability and accuracy of a non-endoscopic screening test for Barrett's oesophagus in primary care: cohort study | BMJ: British Medical Journal | 2010 | 271 |
| 22 | Vandetanib Plus Pemetrexed for the Second-Line Treatment of Advanced Non–Small-Cell Lung Cancer: A Randomized, Double-Blind Phase III Trial | Journal of Clinical Oncology | 2011 | 268 |
| 23 | Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: a national, population‐based study | Clinical Endocrinology | 2012 | 251 |
| 24 | Measurement of Fecal Calprotectin Improves Monitoring and Detection of Recurrence of Crohn's Disease After Surgery | Gastroenterology | 2015 | 241 |
| 25 | Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor | Blood | 2002 | 240 |
| 26 | Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicentre study | European Respiratory Journal | 2017 | 233 |
| 27 | Functional Outcomes after Transoral Robotic Surgery for Head and Neck Cancer | Otolaryngology - Head and Neck Surgery | 2009 | 221 |
| 28 | Serum 25-Hydroxyvitamin D, Calcium Intake, and Risk of Type 2 Diabetes After 5 Years | Diabetes Care | 2011 | 211 |
| 29 | Optimizing targeted therapeutic development: Analysis of a colorectal cancer patient population with the BRAFV600E mutation | International Journal of Cancer | 2011 | 200 |
| 30 | Degenerative Cervical Myelopathy | Neurosurgery | 2015 | 197 |
| 31 | A Multicentre, Randomized, Double-Blinded, Placebo-Controlled Phase III Study to Investigate Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND) | International Journal of Stroke | 2012 | 182 |
| 32 | Risk Stratification for Covert Invasive Cancer Among Patients Referred for Colonic Endoscopic Mucosal Resection: A Large Multicenter Cohort | Gastroenterology | 2017 | 169 |
| 33 | Agreement between arterial and central venous values for pH, bicarbonate, base excess, and lactate | Emergency Medicine Journal | 2006 | 168 |
| 34 | BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression | Clinical Cancer Research | 2017 | 167 |
| 35 | A Binational Multicenter Pilot Feasibility Randomized Controlled Trial of Early Goal-Directed Mobilization in the ICU* | Critical Care Medicine | 2016 | 164 |
| 36 | Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130 | Gastroenterology | 2004 | 163 |
| 37 | Extended Efficacy and Safety of Denosumab in Breast Cancer Patients with Bone Metastases Not Receiving Prior Bisphosphonate Therapy | Clinical Cancer Research | 2008 | 159 |
| 38 | The Incidence of Respiratory Tract Infection in Adults Requiring Hospitalization for Asthma | Chest | 1997 | 151 |
| 39 | A Multicenter, Randomized, Controlled Study to Investigate Extending the Time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial Therapy (EXTEND-IA) | International Journal of Stroke | 2014 | 151 |
| 40 | Randomised trial of intranasal versus intramuscular naloxone in prehospital treatment for suspected opioid overdose | Medical Journal of Australia | 2005 | 147 |
| 41 | Sleep-disordered breathing in stable methadone programme patients: a pilot study | Addiction | 2001 | 139 |
| 42 | Women’s experiences of factors that facilitate or inhibit gestational diabetes self-management | BMC Pregnancy and Childbirth | 2012 | 129 |
| 43 | Venous pH can safely replace arterial pH in the initial evaluation of patients in the emergency department | Emergency Medicine Journal | 2001 | 124 |
| 44 | Id2 Is a Target of the β-Catenin/T Cell Factor Pathway in Colon Carcinoma | Journal of Biological Chemistry | 2001 | 123 |
| 45 | Combining warfarin and antiplatelet therapy after coronary stenting in the Global Registry of Acute Coronary Events: is it safe and effective to use just one antiplatelet agent? | European Heart Journal | 2007 | 121 |
| 46 | Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations | American Journal of Gastroenterology | 2013 | 120 |
| 47 | Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis | Oncogene | 2013 | 117 |
| 48 | Comparison of ECOG/WHO Performance Status and ASA Score as a Measure of Functional Status | Journal of Pain and Symptom Management | 2015 | 117 |
| 49 | Efficacy of thiopurines and adalimumab in preventing Crohn's disease recurrence in high‐risk patients – a POCER study analysis | Alimentary Pharmacology and Therapeutics | 2015 | 115 |
| 50 | Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction | Journal of Molecular and Cellular Cardiology | 2007 | 113 |
