"Diabodies": small bivalent and bispecific antibody fragments | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 754 |
Engineered disulfide bonds as probes of the folding pathway of barnase: increasing the stability of proteins against the rate of denaturation | Biochemistry | 1993 | 336 |
Interaction of barnase with its polypeptide inhibitor barstar studied by protein engineering | Biochemistry | 1993 | 244 |
The sixth Datta Lecture. Protein folding and stability: the pathway of folding of barnase | FEBS Letters | 1993 | 213 |
Retroviral vectors displaying functional antibody fragments | Nucleic Acids Research | 1993 | 192 |
Application of physical organic chemistry to engineered mutants of proteins: Hammond postulate behavior in the transition state of protein folding | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 189 |
Step-wise mutation of barnase to binase. A procedure for engineering increased stability of proteins and an experimental analysis of the evolution of protein stability | Journal of Molecular Biology | 1993 | 157 |
Circular dichroism studies of barnase and its mutants: characterization of the contribution of aromatic side chains | Biochemistry | 1993 | 157 |
Combinatorial infection and in vivo recombination: a strategy for making large phage antibody repertoires | Nucleic Acids Research | 1993 | 152 |
Human antibody fragments specific for human blood group antigens from a phage display library | Nature Biotechnology | 1993 | 151 |
Cloning and sequencing of human immunoglobulin V lambda gene segments | European Journal of Immunology | 1993 | 137 |
The refolding of cis- and trans-peptidylprolyl isomers of barstar | Biochemistry | 1993 | 130 |
Crystal structure of Myxococcus xanthus nucleoside diphosphate kinase and its interaction with a nucleotide substrate at 2.0 A resolution | Journal of Molecular Biology | 1993 | 113 |
Crystal structural analysis of mutations in the hydrophobic cores of barnase | Journal of Molecular Biology | 1993 | 112 |
Expression of a rat neurotensin receptor in Escherichia coli | Biochemical Journal | 1993 | 98 |
Human anti-self antibodies with high specificity from phage display libraries | EMBO Journal | 1993 | 85 |
A complementarity-determining region synthetic peptide acts as a miniantibody and neutralizes human immunodeficiency virus type 1 in vitro | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 71 |
Engineering bispecific antibodies | Current Opinion in Biotechnology | 1993 | 71 |
Contribution of buried hydrogen bonds to protein stability. The crystal structures of two barnase mutants | Journal of Molecular Biology | 1993 | 60 |
Phage and Escherichia coli expression of the human high affinity immunoglobulin E receptor alpha-subunit ectodomain. Domain localization of the IgE-binding site | Journal of Biological Chemistry | 1993 | 60 |
Local breathing and global unfolding in hydrogen exchange of barnase and its relationship to protein folding pathways | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 56 |
A genetic approach to idiotypic vaccination | Journal of Immunotherapy | 1993 | 54 |
Humanized antibodies | Trends in Pharmacological Sciences | 1993 | 51 |
Interactions between active-site-serine beta-lactamases and compounds bearing a methoxy side chain on the alpha-face of the beta-lactam ring: kinetic and molecular modelling studies | Biochemical Journal | 1993 | 51 |
Engineering a novel specificity in subtilisin BPN' | Biochemistry | 1993 | 49 |