| # | Title | Journal | Year | Citations |
|---|
| 1 | Health professionals for a new century: transforming education to strengthen health systems in an interdependent world | Lancet, The | 2010 | 3,851 |
| 2 | Estimates of global seasonal influenza-associated respiratory mortality: a modelling study | Lancet, The | 2018 | 1,870 |
| 3 | Detection of a SARS-CoV-2 variant of concern in South Africa | Nature | 2021 | 1,381 |
| 4 | Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa | Nature | 2022 | 1,210 |
| 5 | Simultaneous Emergence of Multidrug-ResistantCandida aurison 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses | Clinical Infectious Diseases | 2017 | 1,099 |
| 6 | Y chromosome sequence variation and the history of human populations | Nature Genetics | 2000 | 935 |
| 7 | WFH Guidelines for the Management of Hemophilia, 3rd edition | Haemophilia | 2020 | 915 |
| 8 | EFFECT OF DIETARY FIBRE ON STOOLS AND TRANSIT-TIMES, AND ITS ROLE IN THE CAUSATION OF DISEASE | Lancet, The | 1972 | 911 |
| 9 | A Human Genome Diversity Cell Line Panel | Science | 2002 | 907 |
| 10 | Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis | Lancet, The | 2010 | 844 |
| 11 | The “Silent” Global Burden of Congenital Cytomegalovirus | Clinical Microbiology Reviews | 2013 | 771 |
| 12 | Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa | Science | 2022 | 651 |
| 13 | Haplotype Diversity and Linkage Disequilibrium at Human G6PD: Recent Origin of Alleles That Confer Malarial Resistance | Science | 2001 | 590 |
| 14 | Formation of new chromatin domains determines pathogenicity of genomic duplications | Nature | 2016 | 582 |
| 15 | Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis | PLoS Medicine | 2011 | 581 |
| 16 | Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins | Science | 1996 | 576 |
| 17 | Antibiotic Therapy for Klebsiella pneumoniae Bacteremia: Implications of Production of Extended-Spectrum -Lactamases | Clinical Infectious Diseases | 2004 | 512 |
| 18 | Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention | Veterinary Research | 2010 | 502 |
| 19 | Cell Wall Thickening Is a Common Feature of Vancomycin Resistance in Staphylococcus aureus | Journal of Clinical Microbiology | 2003 | 428 |
| 20 | Risk Factors for Coronavirus Disease 2019 (COVID-19) Death in a Population Cohort Study from the Western Cape Province, South Africa | Clinical Infectious Diseases | 2021 | 405 |
| 21 | Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events | Nature Genetics | 2015 | 403 |
| 22 | HIV-1 and recurrence, relapse, and reinfection of tuberculosis after cure: a cohort study in South African mineworkers | Lancet, The | 2001 | 388 |
| 23 | Part I: Cancer in Indigenous Africans—burden, distribution, and trends | Lancet Oncology, The | 2008 | 356 |
| 24 | Epidemiology of Ciprofloxacin Resistance and Its Relationship to Extended-Spectrum -Lactamase Production in Klebsiella pneumoniae Isolates Causing Bacteremia | Clinical Infectious Diseases | 2000 | 342 |
| 25 | The E-cadherin–catenin complex in tumour metastasis | European Journal of Cancer | 2000 | 334 |
| 26 | Maternal Colonization With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses | Clinical Infectious Diseases | 2017 | 329 |
| 27 | Experimental Inoculation of Plants and Animals with Ebola Virus | Emerging Infectious Diseases | 1996 | 326 |
| 28 | Sixteen novel lineages of SARS-CoV-2 in South Africa | Nature Medicine | 2021 | 326 |
| 29 | The Stringent Response of Mycobacterium tuberculosis Is Required for Long-Term Survival | Journal of Bacteriology | 2000 | 306 |
| 30 | Positional cloning of the Fanconi anaemia group A gene | Nature Genetics | 1996 | 294 |
| 31 | Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses | Clinical Infectious Diseases | 2017 | 286 |
| 32 | Taxonomy of the order Bunyavirales: update 2019 | Archives of Virology | 2019 | 285 |
| 33 | Mass gathering events and reducing further global spread of COVID-19: a political and public health dilemma | Lancet, The | 2020 | 275 |
| 34 | Detection of Chlamydia pneumoniae in coronary arterial fatty streaks and atheromatous plaques | South African Medical Journal | 1992 | 275 |
| 35 | Virulence Characteristics ofKlebsiellaand Clinical Manifestations ofK. pneumoniaeBloodstream Infections | Emerging Infectious Diseases | 2007 | 263 |
| 36 | Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes | Nature Genetics | 2010 | 261 |
| 37 | High Polymorphism at the Human Melanocortin 1 Receptor Locus | Genetics | 1999 | 258 |
| 38 | APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans | Journal of the American Society of Nephrology: JASN | 2015 | 256 |
| 39 | Antibodies against Human Herpesvirus 8 in Black South African Patients with Cancer | New England Journal of Medicine | 1999 | 255 |
| 40 | The unicystic ameloblastoma: a clinicopathological study of 57 cases | Journal of Oral Pathology and Medicine | 1988 | 252 |
| 41 | The Geographic Distribution of Human Y Chromosome Variation | Genetics | 1997 | 248 |
| 42 | Fetal Valproate Syndrome: Clinical and Neuro‐developmental Features in Two Sibling Pairs | Developmental Medicine and Child Neurology | 1994 | 247 |
| 43 | High Incidence of Tuberculosis among HIV‐Infected Infants: Evidence from a South African Population‐Based Study Highlights the Need for Improved Tuberculosis Control Strategies | Clinical Infectious Diseases | 2009 | 240 |
| 44 | Chronic pulmonary function impairment caused by initial and recurrent pulmonary tuberculosis following treatment | Thorax | 2000 | 239 |
| 45 | Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis | Antimicrobial Agents and Chemotherapy | 1995 | 238 |
| 46 | THE INFLUENCE OF DIET ON SERUM-TRIGLYCERIDES | Lancet, The | 1961 | 237 |
| 47 | Involvement of the B-lymphoid system in chronic myelogenous leukaemia | Nature | 1980 | 237 |
| 48 | Prediction of aggressive behavior in basal cell carcinoma | Cancer | 1982 | 237 |
| 49 | The role of nanotechnology in the treatment of viral infections | Therapeutic Advances in Infectious Disease | 2017 | 233 |
| 50 | Increased Disease Burden and Antibiotic Resistance of Bacteria Causing Severe Community-Acquired Lower Respiratory Tract Infections in Human Immunodeficiency Virus Type 1-Infected Children | Clinical Infectious Diseases | 2000 | 232 |
