| # | Title | Journal | Year | Citations |
|---|
| 1 | A call for transparent reporting to optimize the predictive value of preclinical research | Nature | 2012 | 1,055 |
| 2 | Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages | Cell Metabolism | 2015 | 887 |
| 3 | Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer | Cell Metabolism | 2016 | 616 |
| 4 | Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis | Nature Chemical Biology | 2012 | 614 |
| 5 | High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 355 |
| 6 | Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System | Neuron | 2018 | 292 |
| 7 | Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes | Cancer Research | 2014 | 277 |
| 8 | The Chemistry Development Kit (CDK) v2.0: atom typing, depiction, molecular formulas, and substructure searching | Journal of Cheminformatics | 2017 | 275 |
| 9 | Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin | Cell Metabolism | 2016 | 269 |
| 10 | CERAPP: Collaborative Estrogen Receptor Activity Prediction Project | Environmental Health Perspectives | 2016 | 264 |
| 11 | Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor | Toxicological Sciences | 2015 | 251 |
| 12 | Increased demand for NAD+ relative to ATP drives aerobic glycolysis | Molecular Cell | 2021 | 232 |
| 13 | PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability | Cancer Discovery | 2017 | 221 |
| 14 | The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics | Frontiers in Pharmacology | 2019 | 179 |
| 15 | KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance | Cancer Cell | 2018 | 170 |
| 16 | Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition | Nature Communications | 2014 | 167 |
| 17 | Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer | ELife | 2017 | 167 |
| 18 | Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives | Drug Discovery Today | 2016 | 162 |
| 19 | TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP) | PLoS Pathogens | 2017 | 160 |
| 20 | Bisphenol A affects androgen receptor function via multiple mechanisms | Chemico-Biological Interactions | 2013 | 154 |
| 21 | Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability | Molecular Psychiatry | 2021 | 139 |
| 22 | GNE myopathy: current update and future therapy | Journal of Neurology, Neurosurgery and Psychiatry | 2015 | 131 |
| 23 | High-potency ligands for DREADD imaging and activation in rodents and monkeys | Nature Communications | 2019 | 128 |
| 24 | Firefly Luciferase in Chemical Biology: A Compendium of Inhibitors, Mechanistic Evaluation of Chemotypes, and Suggested Use As a Reporter | Chemistry and Biology | 2012 | 122 |
| 25 | Antidepressant-relevant concentrations of the ketamine metabolite (2 R ,6 R )-hydroxynorketamine do not block NMDA receptor function | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 120 |
| 26 | Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons | Neuron | 2017 | 118 |
| 27 | Perspectives on validation of high-throughput assays supporting 21st century toxicity testing | ALTEX: Alternatives To Animal Experimentation | 2013 | 118 |
| 28 | A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma | Cell Reports | 2017 | 117 |
| 29 | A Druggable TCF4- and BRD4-Dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm | Cancer Cell | 2016 | 116 |
| 30 | Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies | Nature Communications | 2016 | 113 |
| 31 | ( 2R,6R )-hydroxynorketamine exerts mGlu 2 receptor-dependent antidepressant actions | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 112 |
| 32 | Epigenetic Regulation of SOX9 by the NF-κB Signaling Pathway in Pancreatic Cancer Stem Cells | Stem Cells | 2013 | 111 |
| 33 | The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters | Journal of Biological Chemistry | 2015 | 108 |
| 34 | MEK inhibition induces MYOG and remodels super-enhancers in RAS-driven rhabdomyosarcoma | Science Translational Medicine | 2018 | 104 |
| 35 | Mutation Update forGNEGene Variants Associated with GNE Myopathy | Human Mutation | 2014 | 90 |
| 36 | A framework for the investigation of rare genetic disorders in neuropsychiatry | Nature Medicine | 2019 | 90 |
| 37 | A Selective TSH Receptor Antagonist Inhibits Stimulation of Thyroid Function in Female Mice | Endocrinology | 2014 | 88 |
| 38 | Prediction of human population responses to toxic compounds by a collaborative competition | Nature Biotechnology | 2015 | 88 |
| 39 | Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway | Cell Metabolism | 2020 | 88 |
| 40 | A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome | ELife | 2015 | 87 |
| 41 | Deep learning identifies synergistic drug combinations for treating COVID-19 | Proceedings of the National Academy of Sciences of the United States of America | 2021 | 87 |
| 42 | Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification | Immunity | 2017 | 84 |
| 43 | From scientific discovery to treatments for rare diseases – the view from the National Center for Advancing Translational Sciences – Office of Rare Diseases Research | Orphanet Journal of Rare Diseases | 2018 | 84 |
| 44 | Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation | Blood | 2014 | 81 |
| 45 | Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects | Psychopharmacology | 2018 | 81 |
| 46 | Targeting iron assimilation to develop new antibacterials | Expert Opinion on Drug Discovery | 2012 | 79 |
| 47 | AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice | JCI Insight | 2018 | 79 |
| 48 | The Increasing Urgency for Standards in Basic Biologic Research | Cancer Research | 2014 | 76 |
| 49 | First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis | Arteriosclerosis, Thrombosis, and Vascular Biology | 2017 | 76 |
| 50 | Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterization | Expert Opinion on Drug Discovery | 2013 | 75 |
