| # | Title | Journal | Year | Citations |
|---|
| 1 | Inflammation and cancer | Nature | 2002 | 12,666 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials | BMJ, The | 2013 | 3,435 |
| 4 | The multilayered complexity of ceRNA crosstalk and competition | Nature | 2014 | 3,223 |
| 5 | CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field | Journal of Chemical Theory and Computation | 2016 | 2,567 |
| 6 | A matrix metalloproteinase expressed on the surface of invasive tumour cells | Nature | 1994 | 2,465 |
| 7 | A comparison of direct versus self-report measures for assessing physical activity in adults: a systematic review | International Journal of Behavioral Nutrition and Physical Activity | 2008 | 2,122 |
| 8 | Paradoxical roles of the immune system during cancer development | Nature Reviews Cancer | 2006 | 1,979 |
| 9 | Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial | Lancet Oncology, The | 2012 | 1,879 |
| 10 | Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis | Science | 2000 | 1,828 |
| 11 | Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS | Science | 1984 | 1,488 |
| 12 | The RB and p53 pathways in cancer | Cancer Cell | 2002 | 1,473 |
| 13 | Developing a quality criteria framework for patient decision aids: online international Delphi consensus process | BMJ: British Medical Journal | 2006 | 1,373 |
| 14 | The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues | Molecular Cell | 2000 | 1,303 |
| 15 | Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells | Nature Medicine | 2006 | 1,196 |
| 16 | CircRNA: functions and properties of a novel potential biomarker for cancer | Molecular Cancer | 2017 | 1,157 |
| 17 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 18 | CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication | Science | 1986 | 1,049 |
| 19 | Role of tumor microenvironment in tumorigenesis | Journal of Cancer | 2017 | 1,048 |
| 20 | Nutritional and metabolic assessment of the hospitalized patient | Journal of Parenteral and Enteral Nutrition | 1977 | 1,030 |
| 21 | BrafV600E cooperates with Pten loss to induce metastatic melanoma | Nature Genetics | 2009 | 1,022 |
| 22 | CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth | Cancer Cell | 2011 | 1,020 |
| 23 | Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer | Nature Genetics | 2004 | 976 |
| 24 | Mutations in the Cystic Fibrosis Gene in Patients with Congenital Absence of the Vas Deferens | New England Journal of Medicine | 1995 | 959 |
| 25 | AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 | Nature Genetics | 2000 | 919 |
| 26 | Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy | Molecular Cell | 2013 | 880 |
| 27 | Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line | Blood | 1993 | 836 |
| 28 | S100A8/A9 in Inflammation | Frontiers in Immunology | 2018 | 833 |
| 29 | Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules | Journal of Biological Chemistry | 1997 | 830 |
| 30 | Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool | Cell Stem Cell | 2007 | 780 |
| 31 | Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth | Nature | 1987 | 742 |
| 32 | Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA | Nature | 1993 | 740 |
| 33 | Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis | Journal of Clinical Investigation | 2008 | 706 |
| 34 | Telomerase Maintains Telomere Structure in Normal Human Cells | Cell | 2003 | 689 |
| 35 | Inflammation: Gearing the journey to cancer | Mutation Research - Reviews in Mutation Research | 2008 | 683 |
| 36 | Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp!20 gene | Nature | 1991 | 667 |
| 37 | A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. | EMBO Journal | 1995 | 657 |
| 38 | 5-year analysis of neoadjuvant pertuzumab and trastuzumab in patients with locally advanced, inflammatory, or early-stage HER2-positive breast cancer (NeoSphere): a multicentre, open-label, phase 2 randomised trial | Lancet Oncology, The | 2016 | 623 |
| 39 | Epigenetic Silencing of MicroRNA-34b/c and B-Cell Translocation Gene 4 Is Associated with CpG Island Methylation in Colorectal Cancer | Cancer Research | 2008 | 593 |
| 40 | Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib | Gastroenterology | 2016 | 586 |
| 41 | Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma | Radiotherapy and Oncology | 2005 | 583 |
| 42 | Hepatocyte Growth Factor Induces Gefitinib Resistance of Lung Adenocarcinoma with Epidermal Growth Factor Receptor–Activating Mutations | Cancer Research | 2008 | 574 |
| 43 | Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations | Cell | 2016 | 567 |
| 44 | The functions and regulation of the PTEN tumour suppressor: new modes and prospects | Nature Reviews Molecular Cell Biology | 2018 | 566 |
| 45 | Interaction ofCandida albicanswith Human Leukocytes and Serum | Journal of Bacteriology | 1969 | 565 |
| 46 | Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene | Nature | 1993 | 556 |
| 47 | TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia | Nature | 2010 | 549 |
| 48 | Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity | Cell | 2015 | 504 |
| 49 | mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide | Nature | 2017 | 503 |
| 50 | Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite | Nature | 1983 | 487 |
