| # | Title | Journal | Year | Citations |
|---|
| 1 | The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function | Cell | 2003 | 3,472 |
| 2 | A pyramid approach to subpixel registration based on intensity | IEEE Transactions on Image Processing | 1998 | 2,627 |
| 3 | Prevalence and Co-occurrence of Substance Use Disorders and IndependentMood and Anxiety Disorders | Archives of General Psychiatry | 2004 | 2,493 |
| 4 | The Endocannabinoid System as an Emerging Target of Pharmacotherapy | Pharmacological Reviews | 2006 | 2,274 |
| 5 | Serotonin Transporter Genetic Variation and the Response of the Human Amygdala | Science | 2002 | 2,227 |
| 6 | Neurobiology of addiction: a neurocircuitry analysis | Lancet Psychiatry,the | 2016 | 2,225 |
| 7 | The use of a plus-maze to measure anxiety in the mouse | Psychopharmacology | 1987 | 2,130 |
| 8 | Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications | Nature Reviews Neuroscience | 2011 | 2,029 |
| 9 | Epidemiology ofDSM-5Alcohol Use Disorder | JAMA Psychiatry | 2015 | 1,995 |
| 10 | The role of the basal ganglia in habit formation | Nature Reviews Neuroscience | 2006 | 1,974 |
| 11 | Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens | Journal of Neuroscience | 2001 | 1,815 |
| 12 | Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the national longitudinal alcohol epidemiologic survey | Journal of Substance Abuse | 1997 | 1,592 |
| 13 | Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets | Gastroenterology | 2011 | 1,544 |
| 14 | Ethanol inhibits NMDA-activated ion current in hippocampal neurons | Science | 1989 | 1,356 |
| 15 | AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice | Cell Metabolism | 2011 | 1,356 |
| 16 | The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991–1992 and 2001–2002 | Drug and Alcohol Dependence | 2004 | 1,275 |
| 17 | Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior | Life Sciences | 1983 | 1,194 |
| 18 | FMRI Visualization of Brain Activity during a Monetary Incentive Delay Task | NeuroImage | 2000 | 1,182 |
| 19 | Prevalence, Correlates, Disability, and Comorbidity of DSM-IV Borderline Personality Disorder | Journal of Clinical Psychiatry | 2008 | 1,159 |
| 20 | Nicotine Dependence and Psychiatric Disorders in the United States | Archives of General Psychiatry | 2004 | 1,148 |
| 21 | Epidemiology of Adult DSM-5 Major Depressive Disorder and Its Specifiers in the United States | JAMA Psychiatry | 2018 | 1,107 |
| 22 | Comorbidity of DSM-IV Pathological Gambling and Other Psychiatric Disorders | Journal of Clinical Psychiatry | 2005 | 1,084 |
| 23 | The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample | Drug and Alcohol Dependence | 2003 | 1,060 |
| 24 | Serotonin Transporter Promoter Gain-of-Function Genotypes Are Linked to Obsessive-Compulsive Disorder | American Journal of Human Genetics | 2006 | 1,032 |
| 25 | Cocaine Cues and Dopamine in Dorsal Striatum: Mechanism of Craving in Cocaine Addiction | Journal of Neuroscience | 2006 | 1,021 |
| 26 | Concurrent activation of striatal direct and indirect pathways during action initiation | Nature | 2013 | 1,008 |
| 27 | Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and DSM-IV Alcohol Use Disorder in the United States, 2001-2002 to 2012-2013 | JAMA Psychiatry | 2017 | 1,006 |
| 28 | Adenosine receptors: therapeutic aspects for inflammatory and immune diseases | Nature Reviews Drug Discovery | 2008 | 990 |
| 29 | The ascent of mouse: advances in modelling human depression and anxiety | Nature Reviews Drug Discovery | 2005 | 988 |
| 30 | The global burden of liver disease: The major impact of China | Hepatology | 2014 | 986 |
| 31 | Magnitude of and Trends in Alcohol-Related Mortality and Morbidity Among U.S. College Students Ages 18-24, 1998-2005 | Journal of Studies on Alcohol and Drugs Supplement | 2009 | 962 |
| 32 | The genetics of addictions: uncovering the genes | Nature Reviews Genetics | 2005 | 902 |
| 33 | The Preference of Tryptophan for Membrane Interfaces† | Biochemistry | 1998 | 899 |
| 34 | FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin | Nature | 1992 | 885 |
| 35 | Prevalence of Marijuana Use Disorders in the United States Between 2001-2002 and 2012-2013 | JAMA Psychiatry | 2015 | 851 |
| 36 | Epidemic influenza and vitamin D | Epidemiology and Infection | 2006 | 834 |
| 37 | Mechanisms of action of docosahexaenoic acid in the nervous system | Lipids | 2001 | 812 |
| 38 | Liver: An organ with predominant innate immunity | Hepatology | 2008 | 794 |
| 39 | Prevalence and Axis I comorbidity of full and partial posttraumatic stress disorder in the United States: Results from Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions | Journal of Anxiety Disorders | 2011 | 778 |
| 40 | A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI | NeuroImage | 2003 | 777 |
| 41 | The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression | Metabolic Brain Disease | 2009 | 775 |
| 42 | Lifetime Comorbidity of DSM-IV Mood and Anxiety Disorders and Specific Drug Use Disorders | Journal of Clinical Psychiatry | 2006 | 771 |
| 43 | A Review of Research on the Alcohol Use Disorders Identification Test (AUDIT) | Alcoholism: Clinical and Experimental Research | 1997 | 757 |
| 44 | Addiction: Beyond dopamine reward circuitry | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 733 |
| 45 | Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century | American Journal of Clinical Nutrition | 2011 | 710 |
| 46 | Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology | Philosophical Transactions of the Royal Society B: Biological Sciences | 2008 | 700 |
| 47 | Fish consumption and major depression | Lancet, The | 1998 | 697 |
| 48 | Ethologically-based animal models of anxiety disorders | Lancet, The | 1990 | 682 |
| 49 | Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill | Nature Neuroscience | 2009 | 681 |
| 50 | Epidemiology ofDSM-5Drug Use Disorder | JAMA Psychiatry | 2016 | 675 |
