# | Title | Journal | Year | Citations |
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1 | PD-1 Blockade in Tumors with Mismatch-Repair Deficiency | New England Journal of Medicine | 2015 | 7,696 |
2 | Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade | Science | 2017 | 4,945 |
3 | Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial | Lancet, The | 2006 | 2,349 |
4 | Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study | Journal of Clinical Oncology | 2020 | 1,740 |
5 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
6 | Human natural killer cells | Blood | 2008 | 1,572 |
7 | Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study | Lancet Oncology, The | 2020 | 1,363 |
8 | Prevalence of Oral HPV Infection in the United States, 2009-2010 | JAMA - Journal of the American Medical Association | 2012 | 875 |
9 | Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy | JAMA - Journal of the American Medical Association | 2013 | 785 |
10 | Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 | JAMA Oncology | 2022 | 719 |
11 | Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer | JAMA - Journal of the American Medical Association | 2017 | 670 |
12 | Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells | Cancer Cell | 2013 | 665 |
13 | MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 641 |
14 | Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations | Annals of Oncology | 2015 | 607 |
15 | microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer | Oncogene | 2011 | 600 |
16 | The genomic landscape of hypodiploid acute lymphoblastic leukemia | Nature Genetics | 2013 | 588 |
17 | PTEN Mutation Spectrum and Genotype-Phenotype Correlations in Bannayan-Riley-Ruvalcaba Syndrome Suggest a Single Entity With Cowden Syndrome | Human Molecular Genetics | 1999 | 562 |
18 | The World Health Organization Classification of Neoplastic Diseases of the Hematopoietic and Lymphoid Tissues | Annals of Oncology | 1999 | 532 |
19 | MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 488 |
20 | Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer | Molecular Cell | 1999 | 485 |
21 | Bevacizumab and paclitaxel–carboplatin chemotherapy and secondary cytoreduction in recurrent, platinum-sensitive ovarian cancer (NRG Oncology/Gynecologic Oncology Group study GOG-0213): a multicentre, open-label, randomised, phase 3 trial | Lancet Oncology, The | 2017 | 460 |
22 | Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 443 |
23 | Aromatase Inhibitors in the Treatment of Breast Cancer | Endocrine Reviews | 2005 | 431 |
24 | The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: Impact and Future Directions | Journal of Nutrition | 2020 | 386 |
25 | Preclinical characterization of 1-7F9, a novel human anti–KIR receptor therapeutic antibody that augments natural killer–mediated killing of tumor cells | Blood | 2009 | 363 |
26 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics | Cell Research | 2015 | 354 |
27 | Long-term follow-up of MCL patients treated with single-agent ibrutinib: updated safety and efficacy results | Blood | 2015 | 349 |
28 | Immunohistochemical Evidence of Loss of PTEN Expression in Primary Ductal Adenocarcinomas of the Breast | American Journal of Pathology | 1999 | 342 |
29 | MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2) | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 333 |
30 | Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 328 |
31 | Optimizing Autologous Stem Cell Mobilization Strategies to Improve Patient Outcomes: Consensus Guidelines and Recommendations | Biology of Blood and Marrow Transplantation | 2014 | 305 |
32 | TET2 Mutations Improve the New European LeukemiaNet Risk Classification of Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study | Journal of Clinical Oncology | 2011 | 291 |
33 | Final Overall Survival of a Randomized Trial of Bevacizumab for Primary Treatment of Ovarian Cancer | Journal of Clinical Oncology | 2019 | 289 |
34 | Location and cellular stages of natural killer cell development | Trends in Immunology | 2013 | 288 |
35 | Differential Nuclear and Cytoplasmic Expression of PTEN in Normal Thyroid Tissue, and Benign and Malignant Epithelial Thyroid Tumors | American Journal of Pathology | 2000 | 283 |
36 | Durable Tumor Regression and Overall Survival in Patients With Advanced Merkel Cell Carcinoma Receiving Pembrolizumab as First-Line Therapy | Journal of Clinical Oncology | 2019 | 274 |
37 | Clinical Relevance of Microsatellite Instability in Colorectal Cancer | Journal of Clinical Oncology | 2010 | 273 |
38 | Molecular Markers Identify Subtypes of Stage III Colon Cancer Associated With Patient Outcomes | Gastroenterology | 2015 | 273 |
39 | MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer | Cancer Cell | 2014 | 267 |
40 | Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 alteration | Nature Medicine | 2020 | 255 |
41 | Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study | Lancet Oncology, The | 2015 | 249 |
42 | RUNX1 Mutations Are Associated With Poor Outcome in Younger and Older Patients With Cytogenetically Normal Acute Myeloid Leukemia and With Distinct Gene and MicroRNA Expression Signatures | Journal of Clinical Oncology | 2012 | 242 |
43 | Myc Requires Distinct E2F Activities to Induce S Phase and Apoptosis | Molecular Cell | 2001 | 233 |
44 | CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets | Blood | 2010 | 228 |
45 | Postibrutinib outcomes in patients with mantle cell lymphoma | Blood | 2016 | 228 |
46 | Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer | Current Pharmaceutical Design | 2014 | 228 |
47 | Paclitaxel-Loaded Gelatin Nanoparticles for Intravesical Bladder Cancer Therapy | Clinical Cancer Research | 2004 | 225 |
48 | The Epidemiology of Arm and Hand Swelling in Premenopausal Breast Cancer Survivors | Cancer Epidemiology Biomarkers and Prevention | 2007 | 224 |
49 | Long-term clinical outcomes of tisagenlecleucel in patients with relapsed or refractory aggressive B-cell lymphomas (JULIET): a multicentre, open-label, single-arm, phase 2 study | Lancet Oncology, The | 2021 | 222 |
50 | LINE-1 Hypomethylation in Cancer Is Highly Variable and Inversely Correlated with Microsatellite Instability | PLoS ONE | 2007 | 221 |