Institute for Basic Science

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Top Articles

#	Title	Journal	Year	Citations
1	Microbial Hub Taxa Link Host and Abiotic Factors to Plant Microbiome Variation	PLoS Biology	2016	1,065
2	The use of elemental sulfur as an alternative feedstock for polymeric materials	Nature Chemistry	2013	1,046
3	Magnetism in two-dimensional van der Waals materials	Nature	2018	994
4	A guide to genome engineering with programmable nucleases	Nature Reviews Genetics	2014	990
5	DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins	Nature Biotechnology	2015	975
6	Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells	Nature Methods	2015	850
7	Correction of a pathogenic gene mutation in human embryos	Nature	2017	781
8	Building better biomarkers: brain models in translational neuroimaging	Nature Neuroscience	2017	764
9	The Role of Intrinsic Defects in Methylammonium Lead Iodide Perovskite	Journal of Physical Chemistry Letters	2014	744
10	Nonstandard heavy mesons and baryons: Experimental evidence	Reviews of Modern Physics	2018	501
11	Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology	Science	2017	497
12	Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid	Nature	2019	445
13	CRISPR/Cpf1-mediated DNA-free plant genome editing	Nature Communications	2017	386
14	Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders	Biological Psychiatry	2017	370
15	Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy	Nature Biotechnology	2018	345
16	Microhomology-based choice of Cas9 nuclease target sites	Nature Methods	2014	336
17	Highly efficient RNA-guided base editing in mouse embryos	Nature Biotechnology	2017	330
18	Cas-analyzer: an online tool for assessing genome editing results using NGS data	Bioinformatics	2017	313
19	YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation	Journal of Clinical Investigation	2017	282
20	Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development	Cell Host and Microbe	2018	277
21	Plant leaf senescence and death – regulation by multiple layers of control and implications for aging in general	Journal of Cell Science	2013	263
22	Suppression of magnetic ordering in XXZ-type antiferromagnetic monolayer NiPS3	Nature Communications	2019	255
23	DNA-free two-gene knockout in Chlamydomonas reinhardtii via CRISPR-Cas9 ribonucleoproteins	Scientific Reports	2016	253
24	Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action	Bioorganic and Medicinal Chemistry	1999	235
25	Precision genome engineering through adenine base editing in plants	Nature Plants	2018	227
26	Biological functions of lymphatic vessels	Science	2020	220
27	Polar amplification dominated by local forcing and feedbacks	Nature Climate Change	2018	216
28	42 PW, 20 fs Ti:sapphire laser at 01 Hz	Optics Letters	2017	202
29	A Photoresponsive Smart Covalent Organic Framework	Angewandte Chemie - International Edition	2015	200
30	Targeted mutagenesis in mice by electroporation of Cpf1 ribonucleoproteins	Nature Biotechnology	2016	191
31	Attosecond angular streaking and tunnelling time in atomic hydrogen	Nature	2019	190
32	Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex	Nature Neuroscience	2018	187
33	Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy	Nature Communications	2014	184
34	Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq	Genome Research	2016	184
35	Proteogenomic Characterization of Human Early-Onset Gastric Cancer	Cancer Cell	2019	183
36	C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation	Nature Communications	2015	182
37	Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9	Molecules and Cells	2015	181
38	Volume-conserving trans–cis isomerization pathways in photoactive yellow protein visualized by picosecond X-ray crystallography	Nature Chemistry	2013	178
39	CRISPR RNAs trigger innate immune responses in human cells	Genome Research	2018	177
40	Deep optical imaging within complex scattering media	Nature Reviews Physics	2020	176
41	Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression	Nature Neuroscience	2015	168
42	Catalytic Dearomatization of N‐Heteroarenes with Silicon and Boron Compounds	Angewandte Chemie - International Edition	2017	160
43	Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis	Nature Communications	2016	159
44	IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production	Mucosal Immunology	2015	157
45	Free-Standing, Single-Monomer-Thick Two-Dimensional Polymers through Covalent Self-Assembly in Solution	Journal of the American Chemical Society	2013	154
46	Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production	Nature Neuroscience	2020	154
47	Genome-wide target specificity of CRISPR RNA-guided adenine base editors	Nature Biotechnology	2019	151
48	Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit	Frontiers in Cellular Neuroscience	2015	148
49	Direct observation of DNA target searching and cleavage by CRISPR-Cas12a	Nature Communications	2018	148
50	Stem-piped light activates phytochrome B to trigger light responses in Arabidopsis thaliana roots	Science Signaling	2016	145

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