| # | Title | Journal | Year | Citations |
|---|
| 1 | Richness of human gut microbiome correlates with metabolic markers | Nature | 2013 | 3,641 |
| 2 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 3 | Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma | New England Journal of Medicine | 2015 | 948 |
| 4 | Magnetic resonance imaging for clinical management of rectal cancer: Updated recommendations from the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting | European Radiology | 2018 | 592 |
| 5 | First-line chemoimmunotherapy with bendamustine and rituximab versus fludarabine, cyclophosphamide, and rituximab in patients with advanced chronic lymphocytic leukaemia (CLL10): an international, open-label, randomised, phase 3, non-inferiority trial | Lancet Oncology, The | 2016 | 529 |
| 6 | MRI characteristics of neuromyelitis optica spectrum disorder | Neurology | 2015 | 523 |
| 7 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 8 | Atlas of the clinical genetics of human dilated cardiomyopathy | European Heart Journal | 2015 | 456 |
| 9 | High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational study | Lancet Oncology, The | 2015 | 435 |
| 10 | Loss-of-function mutations in SLC30A8 protect against type 2 diabetes | Nature Genetics | 2014 | 428 |
| 11 | Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer | JAMA - Journal of the American Medical Association | 2015 | 390 |
| 12 | The emerging roles of circRNAs in cancer and oncology | Nature Reviews Clinical Oncology | 2022 | 387 |
| 13 | Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery | Gut | 2016 | 381 |
| 14 | Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study | Blood | 2008 | 369 |
| 15 | DBCG-IMN: A Population-Based Cohort Study on the Effect of Internal Mammary Node Irradiation in Early Node-Positive Breast Cancer | Journal of Clinical Oncology | 2016 | 356 |
| 16 | Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer | Nature Genetics | 2017 | 356 |
| 17 | Klinefelter Syndrome—A Clinical Update | Journal of Clinical Endocrinology and Metabolism | 2013 | 355 |
| 18 | Clinical efficacy of daratumumab monotherapy in patients with heavily pretreated relapsed or refractory multiple myeloma | Blood | 2016 | 347 |
| 19 | Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes | Nature Genetics | 2014 | 294 |
| 20 | Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer | Nature Genetics | 2017 | 289 |
| 21 | Risk of recurrence in patients with colon cancer stage II and III: A systematic review and meta-analysis of recent literature | Acta Oncológica | 2015 | 270 |
| 22 | A Physical Mechanism for Coupling Bone Resorption and Formation in Adult Human Bone | American Journal of Pathology | 2009 | 267 |
| 23 | A population-based cohort study of rheumatoid arthritis-associated interstitial lung disease: comorbidity and mortality | Annals of the Rheumatic Diseases | 2017 | 263 |
| 24 | Axillary dissection of level I and II lymph nodes is important in breast cancer classification | European Journal of Cancer | 1992 | 250 |
| 25 | First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: results of a phase 1/2 trial | Blood | 2008 | 247 |
| 26 | Quantitative Cell-Free DNA, KRAS, and BRAF Mutations in Plasma from Patients with Metastatic Colorectal Cancer during Treatment with Cetuximab and Irinotecan | Clinical Cancer Research | 2012 | 244 |
| 27 | Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk | PLoS Genetics | 2013 | 244 |
| 28 | A comparison of single-lead atrial pacing with dual-chamber pacing in sick sinus syndrome | European Heart Journal | 2011 | 241 |
| 29 | Which goal for fluid therapy during colorectal surgery is followed by the best outcome: near-maximal stroke volume or zero fluid balance? | British Journal of Anaesthesia | 2012 | 238 |
| 30 | Surveillance following orchidectomy for stage I seminoma of the testis | European Journal of Cancer | 1993 | 232 |
| 31 | Klinefelter syndrome in clinical practice | Nature Reviews Urology | 2007 | 225 |
| 32 | Magnetic resonance imaging for the clinical management of rectal cancer patients: recommendations from the 2012 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting | European Radiology | 2013 | 222 |
| 33 | Identification of six new susceptibility loci for invasive epithelial ovarian cancer | Nature Genetics | 2015 | 221 |
| 34 | Radiation Dose-Response Model for Locally Advanced Rectal Cancer After Preoperative Chemoradiation Therapy | International Journal of Radiation Oncology Biology Physics | 2013 | 219 |
| 35 | MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients | Journal of Neuroinflammation | 2016 | 217 |
| 36 | Efficacy of Margetuximab vs Trastuzumab in Patients With Pretreated ERBB2-Positive Advanced Breast Cancer | JAMA Oncology | 2021 | 217 |
| 37 | Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography | Multiple Sclerosis Journal | 2015 | 209 |
| 38 | Treatment response, drug survival, and predictors thereof in 764 patients with psoriatic arthritis treated with anti–tumor necrosis factor α therapy: Results from the nationwide Danish DANBIO registry | Arthritis and Rheumatism | 2011 | 204 |
| 39 | A nationwide non-medical switch from originator infliximab to biosimilar CT-P13 in 802 patients with inflammatory arthritis: 1-year clinical outcomes from the DANBIO registry | Annals of the Rheumatic Diseases | 2017 | 204 |
| 40 | Improved heart, lung and target dose with deep inspiration breath hold in a large clinical series of breast cancer patients | Radiotherapy and Oncology | 2013 | 196 |
| 41 | Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study | European Urology | 2014 | 195 |
| 42 | Cancers take their Toll—the function and regulation of Toll-like receptors in cancer cells | Oncogene | 2008 | 192 |
| 43 | Management and follow-up of gallbladder polyps | European Radiology | 2017 | 191 |
| 44 | Digoxin-verapamil interaction | Clinical Pharmacology and Therapeutics | 1981 | 190 |
| 45 | Thymidylate Synthase and Methylenetetrahydrofolate Reductase Gene Polymorphism in Normal Tissue As Predictors of Fluorouracil Sensitivity | Journal of Clinical Oncology | 2005 | 190 |
| 46 | The Nottingham Prognostic Index applied to 9,149 patients from the studies of the Danish Breast Cancer Cooperative Group (DBCG) | Breast Cancer Research and Treatment | 1994 | 186 |
| 47 | Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial) - a randomized, multidisciplinary, multinational phase III trial | BMC Cancer | 2015 | 182 |
| 48 | Clinical efficacy and management of monoclonal antibodies targeting CD38 and SLAMF7 in multiple myeloma | Blood | 2016 | 179 |
| 49 | Breakthrough Cancer Pain: An Observational Study of 1000 European Oncology Patients | Journal of Pain and Symptom Management | 2013 | 171 |
| 50 | Long‐term mortality and renal outcome in a cohort of 100 patients with Lupus Nephritis | Arthritis Care and Research | 2010 | 170 |
