| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial | Lancet, The | 2005 | 3,840 |
| 3 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 4 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 5 | A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial | Lancet, The | 2015 | 2,307 |
| 6 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk | Nature Genetics | 2010 | 1,982 |
| 7 | Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial | Lancet, The | 1999 | 1,938 |
| 8 | Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes | Nature Genetics | 2008 | 1,683 |
| 9 | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | Nature Genetics | 2010 | 1,631 |
| 10 | Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial | Lancet, The | 2002 | 1,621 |
| 11 | Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study | BMJ: British Medical Journal | 2001 | 1,298 |
| 12 | Body mass index as a predictor of fracture risk: A meta-analysis | Osteoporosis International | 2005 | 1,292 |
| 13 | A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity | Nature Genetics | 1998 | 1,262 |
| 14 | Predictive Value of BMD for Hip and Other Fractures | Journal of Bone and Mineral Research | 2005 | 1,213 |
| 15 | 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study) | Lancet, The | 2009 | 1,179 |
| 16 | Increased Mortality Associated with Growth Hormone Treatment in Critically Ill Adults | New England Journal of Medicine | 1999 | 1,124 |
| 17 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 18 | A meta-analysis of previous fracture and subsequent fracture risk | Bone | 2004 | 1,052 |
| 19 | A Prospective, Randomized Study of Goal-Oriented Hemodynamic Therapy in Cardiac Surgical Patients | Anesthesia and Analgesia | 2000 | 1,028 |
| 20 | Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial | Annals of Oncology | 2014 | 1,022 |
| 21 | The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study | Intensive Care Medicine | 1999 | 983 |
| 22 | Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity | European Heart Journal | 2005 | 979 |
| 23 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 960 |
| 24 | Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study | Lancet, The | 2009 | 931 |
| 25 | Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease | Lancet Neurology, The | 2005 | 874 |
| 26 | Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution | Nature Genetics | 2010 | 836 |
| 27 | Testosterone and Sex Hormone–Binding Globulin Predict the Metabolic Syndrome and Diabetes in Middle-Aged Men | Diabetes Care | 2004 | 803 |
| 28 | Pain after Cardiac Surgery | Anesthesiology | 2006 | 783 |
| 29 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 30 | ILAE Treatment Guidelines: Evidence-based Analysis of Antiepileptic Drug Efficacy and Effectiveness as Initial Monotherapy for Epileptic Seizures and Syndromes | Epilepsia | 2006 | 782 |
| 31 | EUROASPIRE IV: A European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries | European Journal of Preventive Cardiology | 2016 | 772 |
| 32 | Metabolic Syndrome and Development of Diabetes Mellitus: Application and Validation of Recently Suggested Definitions of the Metabolic Syndrome in a Prospective Cohort Study | American Journal of Epidemiology | 2002 | 756 |
| 33 | Smoking and fracture risk: a meta-analysis | Osteoporosis International | 2005 | 755 |
| 34 | Common variants associated with plasma triglycerides and risk for coronary artery disease | Nature Genetics | 2013 | 754 |
| 35 | Cerebrospinal Fluid β-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain | Archives of Neurology | 2009 | 747 |
| 36 | Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I, II, and III surveys in eight European countries | Lancet, The | 2009 | 737 |
| 37 | EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries | European Journal of Cardiovascular Prevention and Rehabilitation | 2009 | 677 |
| 38 | Neuronal responses to magnetic stimulation reveal cortical reactivity and connectivity | NeuroReport | 1997 | 675 |
| 39 | The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm | Nature Genetics | 2008 | 668 |
| 40 | Variants in MTNR1B influence fasting glucose levels | Nature Genetics | 2009 | 662 |
| 41 | Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion | Nature Genetics | 2009 | 642 |
| 42 | Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial | Lancet, The | 2016 | 620 |
| 43 | Effect of dopexamine on outcome after major abdominal surgery: A prospective, randomized, controlled multicenter study | Critical Care Medicine | 2000 | 610 |
| 44 | Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes | Epilepsia | 2013 | 599 |
| 45 | The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 598 |
| 46 | Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy | Lancet Neurology, The | 2002 | 563 |
| 47 | Uric Acid Level as a Risk Factor for Cardiovascular and All-Cause Mortality in Middle-aged Men | Archives of Internal Medicine | 2004 | 557 |
| 48 | A catalog of genetic loci associated with kidney function from analyses of a million individuals | Nature Genetics | 2019 | 549 |
| 49 | CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease | Brain | 2006 | 541 |
| 50 | Hippocampus and entorhinal cortex in mild cognitive impairment and early AD | Neurobiology of Aging | 2004 | 539 |
