| # | Title | Journal | Year | Citations |
|---|
| 1 | Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease | Nature Genetics | 2009 | 1,217 |
| 2 | Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI | JAMA - Journal of the American Medical Association | 2019 | 602 |
| 3 | Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection | Hepatology | 2014 | 517 |
| 4 | Limitation of combination therapy of interferon and ribavirin for older patients with chronic hepatitis C | Hepatology | 2006 | 387 |
| 5 | A reassessment of risks and benefits of dopamine agonists in Parkinson's disease | Lancet Neurology, The | 2009 | 169 |
| 6 | Clinical efficacy of istradefylline (KW‐6002) in Parkinson's disease: A randomized, controlled study | Movement Disorders | 2010 | 168 |
| 7 | Validation of Modified ALBI Grade for More Detailed Assessment of Hepatic Function in Hepatocellular Carcinoma Patients: A Multicenter Analysis | Liver Cancer | 2019 | 159 |
| 8 | Risk factors for perforation and delayed bleeding associated with endoscopic submucosal dissection for early gastric neoplasms: Analysis of 1123 lesions | Journal of Gastroenterology and Hepatology (Australia) | 2012 | 155 |
| 9 | Prognostic factor of lenvatinib for unresectable hepatocellular carcinoma in real‐world conditions—Multicenter analysis | Cancer Medicine | 2019 | 131 |
| 10 | Tolvaptan for improvement of hepatic edema: A phase 3, multicenter, randomized, double‐blind, placebo‐controlled trial | Hepatology Research | 2014 | 128 |
| 11 | Amantadine for Dyskinesias in Parkinson's Disease: A Randomized Controlled Trial | PLoS ONE | 2010 | 120 |
| 12 | Middle meningeal artery embolization for refractory chronic subdural hematoma | Journal of Neurosurgery | 2000 | 116 |
| 13 | Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection | Gastroenterology | 2017 | 115 |
| 14 | Dopamine agonists and cardiac valvulopathy in Parkinson disease: A case-control study | Neurology | 2006 | 112 |
| 15 | Clinical features of lenvatinib for unresectable hepatocellular carcinoma in real‐world conditions: Multicenter analysis | Cancer Medicine | 2019 | 112 |
| 16 | Long-term use of entecavir in nucleoside-naïve Japanese patients with chronic hepatitis B infection | Journal of Hepatology | 2010 | 105 |
| 17 | Deep Neural Networks for Dental Implant System Classification | Biomolecules | 2020 | 100 |
| 18 | Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy | Journal of the Neurological Sciences | 2001 | 99 |
| 19 | Effectiveness of simplified 15-min refresher BLS training program: A randomized controlled trial | Resuscitation | 2015 | 97 |
| 20 | Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 2 hepatitis C virus infection | Hepatology | 2018 | 94 |
| 21 | A Screening test for the prediction of Dravet syndrome before one year of age | Epilepsia | 2008 | 92 |
| 22 | Overview of innovative advances in bioresorbable plate systems for oral and maxillofacial surgery | Japanese Dental Science Review | 2018 | 91 |
| 23 | Persistent normalization of serum alanine aminotransferase levels improves the prognosis of type 1 autoimmune hepatitis | Journal of Hepatology | 2005 | 90 |
| 24 | Variants associated with Gaucher disease in multiple system atrophy | Annals of Clinical and Translational Neurology | 2015 | 90 |
| 25 | Long-term outcome of intralesional injection of triamcinolone acetonide for the treatment of keloid scars in Asian patients | Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery | 2006 | 89 |
| 26 | Association of Higher Methotrexate Dose With Lymphoproliferative Disease Onset in Rheumatoid Arthritis Patients | Arthritis Care and Research | 2014 | 81 |
| 27 | Therapeutic potential of lenvatinib for unresectable hepatocellular carcinoma in clinical practice: Multicenter analysis | Hepatology Research | 2019 | 81 |
| 28 | Application of computer-assisted navigation systems in oral and maxillofacial surgery | Japanese Dental Science Review | 2018 | 80 |
| 29 | Multi-center randomized controlled study to establish the standard third-line regimen for Helicobacter pylori eradication in Japan | Journal of Gastroenterology | 2013 | 75 |
| 30 | Randomized, double-blind study of pramipexole with placebo and bromocriptine in advanced Parkinson's disease | Movement Disorders | 2003 | 74 |
| 31 | Safety and efficacy of dual direct-acting antiviral therapy (daclatasvir and asunaprevir) for chronic hepatitis C virus genotype 1 infection in patients on hemodialysis | Journal of Gastroenterology | 2016 | 72 |
| 32 | Deep Learning for Osteoporosis Classification Using Hip Radiographs and Patient Clinical Covariates | Biomolecules | 2020 | 72 |
| 33 | Interleukin-1beta genetic polymorphism influences the effect of cytochrome P 2C19 genotype on the cure rate of 1-week triple therapy for Helicobacter pylori infection | American Journal of Gastroenterology | 2003 | 71 |
| 34 | Randomized open trial for comparison of proton pump inhibitors in triple therapy for Helicobacter pylori infection in relation to CYP2C19 genotype | Journal of Gastroenterology and Hepatology (Australia) | 2002 | 70 |
| 35 | The characteristics and outcomes of small bowel adenocarcinoma: a multicentre retrospective observational study | British Journal of Cancer | 2017 | 67 |
| 36 | Early initiation of eicosapentaenoic acid and statin treatment is associated with better clinical outcomes than statin alone in patients with acute coronary syndromes: 1-year outcomes of a randomized controlled study | International Journal of Cardiology | 2017 | 66 |
| 37 | Important Clinical Factors in Sequential Therapy Including Lenvatinib against Unresectable Hepatocellular Carcinoma | Oncology | 2019 | 66 |
| 38 | Transition in the etiology of liver cirrhosis in Japan: a nationwide survey | Journal of Gastroenterology | 2020 | 65 |
| 39 | Risk factors for hepatocellular carcinoma in Hepatitis C patients with sustained virologic response to interferon therapy | Liver International | 2004 | 64 |
| 40 | Eradication of Helicobacter pylori increases platelet count in patients with idiopathic thrombocytopenic purpura in Japan | European Journal of Clinical Investigation | 2005 | 63 |
| 41 | LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease | Movement Disorders | 2009 | 60 |
| 42 | Elevation of Anti-Cytokeratin 18 Antibody and Circulating Cytokeratin 18: Anti-Cytokeratin 18 Antibody Immune Complexes in Sera of Patients with Idiopathic Pulmonary Fibrosis | Lung | 2000 | 58 |
| 43 | Persistent elevation of serum alanine aminotransferase levels leads to poor survival and hepatocellular carcinoma development in type 1 autoimmune hepatitis | Alimentary Pharmacology and Therapeutics | 2006 | 58 |
| 44 | Calbindin 1, fibroblast growth factor 20, and α-synuclein in sporadic Parkinson’s disease | Human Genetics | 2008 | 56 |
| 45 | Long-Term Skeletal Stability After Maxillary Advancement With Distraction Osteogenesis in Nongrowing Patients | Journal of Oral and Maxillofacial Surgery | 2008 | 56 |
| 46 | Changes in hepatitis C virus genotype distribution in Japan | Epidemiology and Infection | 2014 | 56 |
| 47 | Outcome after External Decompression for Massive Cerebral Infarction | Neurologia Medico-Chirurgica | 1998 | 54 |
| 48 | Clinical features of non-specific interstitial pneumonia | Respiratory Medicine | 1999 | 54 |
| 49 | Heparin inhibits osteoclastic differentiation and function | Journal of Cellular Biochemistry | 2008 | 51 |
| 50 | Neutrophil‐to‐lymphocyte ratio is associated with survival in patients with unresectable hepatocellular carcinoma treated with lenvatinib | Liver International | 2020 | 51 |
