| # | Title | Journal | Year | Citations |
|---|
| 1 | Toll-like receptor signalling | Nature Reviews Immunology | 2004 | 7,318 |
| 2 | A Toll-like receptor recognizes bacterial DNA | Nature | 2000 | 5,827 |
| 3 | Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells | Nature | 2013 | 3,901 |
| 4 | Raman spectroscopy of carbon nanotubes | Physics Reports | 2005 | 3,709 |
| 5 | Double-Network Hydrogels with Extremely High Mechanical Strength | Advanced Materials | 2003 | 3,537 |
| 6 | Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses | Nature | 2006 | 3,292 |
| 7 | The role of autophagy during the early neonatal starvation period | Nature | 2004 | 2,630 |
| 8 | Photocatalyst releasing hydrogen from water | Nature | 2006 | 2,627 |
| 9 | Real-space observation of a two-dimensional skyrmion crystal | Nature | 2010 | 2,626 |
| 10 | Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 2,563 |
| 11 | Ordered nanoporous arrays of carbon supporting high dispersions of platinum nanoparticles | Nature | 2001 | 2,439 |
| 12 | Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota | Nature | 2013 | 2,339 |
| 13 | Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway | Nature Immunology | 2002 | 2,290 |
| 14 | IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction | Nature Immunology | 2005 | 2,254 |
| 15 | Internal models in the cerebellum | Trends in Cognitive Sciences | 1998 | 2,167 |
| 16 | An ultra-lightweight design for imperceptible plastic electronics | Nature | 2013 | 2,133 |
| 17 | Multiple paired forward and inverse models for motor control | Neural Networks | 1998 | 2,069 |
| 18 | TLR signaling pathways | Seminars in Immunology | 2004 | 2,017 |
| 19 | MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis | Nature Methods | 2015 | 1,955 |
| 20 | Signaling to NF-κB by Toll-like receptors | Trends in Molecular Medicine | 2007 | 1,932 |
| 21 | Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) Function as Transcriptional Activators in Abscisic Acid Signaling | Plant Cell | 2003 | 1,905 |
| 22 | Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome | Nature | 2013 | 1,774 |
| 23 | Frequent pathway mutations of splicing machinery in myelodysplasia | Nature | 2011 | 1,764 |
| 24 | TLR signaling | Cell Death and Differentiation | 2006 | 1,724 |
| 25 | Superconductivity in two-dimensional CoO2 layers | Nature | 2003 | 1,706 |
| 26 | Innate immune recognition of viral infection | Nature Immunology | 2006 | 1,654 |
| 27 | Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron | Nature | 2004 | 1,540 |
| 28 | Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death | Nature | 2005 | 1,464 |
| 29 | Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons | Nature Neuroscience | 2001 | 1,413 |
| 30 | TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity | Nature | 2007 | 1,405 |
| 31 | Near room-temperature formation of a skyrmion crystal in thin-films of the helimagnet FeGe | Nature Materials | 2011 | 1,374 |
| 32 | FD, a bZIP Protein Mediating Signals from the Floral Pathway Integrator FT at the Shoot Apex | Science | 2005 | 1,328 |
| 33 | Quantized conductance through individual rows of suspended gold atoms | Nature | 1998 | 1,325 |
| 34 | An ordered mesoporous organosilica hybrid material with a crystal-like wall structure | Nature | 2002 | 1,305 |
| 35 | Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells | Journal of Cell Biology | 2001 | 1,282 |
| 36 | Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 1,279 |
| 37 | Cell Type-Specific Involvement of RIG-I in Antiviral Response | Immunity | 2005 | 1,221 |
| 38 | Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling | Journal of Immunology | 2002 | 1,123 |
| 39 | The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway | Nature | 1999 | 1,118 |
| 40 | High-mobility thin-film transistor with amorphous InGaZnO4 channel fabricated by room temperature rf-magnetron sputtering | Applied Physics Letters | 2006 | 1,048 |
| 41 | Chirality-Sensing Supramolecular Systems | Chemical Reviews | 2008 | 1,032 |
| 42 | Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains | Cell | 2002 | 1,013 |
| 43 | The central nervous system stabilizes unstable dynamics by learning optimal impedance | Nature | 2001 | 999 |
| 44 | Magnetic and martensitic transformations of NiMnX(X=In,Sn,Sb) ferromagnetic shape memory alloys | Applied Physics Letters | 2004 | 990 |
| 45 | Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes | Journal of Immunology | 2001 | 986 |
| 46 | Essential role of MD-2 in LPS responsiveness and TLR4 distribution | Nature Immunology | 2002 | 940 |
| 47 | TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway | Nature Immunology | 2003 | 919 |
| 48 | Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 | Nature | 2002 | 910 |
| 49 | Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 | Nature Immunology | 2004 | 894 |
| 50 | Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 884 |
