| # | Title | Journal | Year | Citations |
|---|
| 1 | Delayed neuronal death in the gerbil hippocampus following ischemia | Brain Research | 1982 | 2,814 |
| 2 | Klotho converts canonical FGF receptor into a specific receptor for FGF23 | Nature | 2006 | 1,625 |
| 3 | FGF-23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis | Journal of Bone and Mineral Research | 2004 | 1,554 |
| 4 | Colorectal cancer | Nature Reviews Disease Primers | 2015 | 1,104 |
| 5 | International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values | Journal of Diabetes Investigation | 2012 | 731 |
| 6 | Circulating Exosomal microRNAs as Biomarkers of Colon Cancer | PLoS ONE | 2014 | 669 |
| 7 | “Nonswellable” Hydrogel Without Mechanical Hysteresis | Science | 2014 | 511 |
| 8 | Decreased extra-renal urate excretion is a common cause of hyperuricemia | Nature Communications | 2012 | 489 |
| 9 | Illusion of sense of self-agency: discrepancy between the predicted and actual sensory consequences of actions modulates the sense of self-agency, but not the sense of self-ownership | Cognition | 2005 | 446 |
| 10 | Deep Learning with Convolutional Neural Network for Differentiation of Liver Masses at Dynamic Contrast-enhanced CT: A Preliminary Study | Radiology | 2018 | 446 |
| 11 | JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure ― Digest Version ― | Circulation Journal | 2019 | 446 |
| 12 | Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid | Journal of Biological Chemistry | 2006 | 418 |
| 13 | Overlapping demyelinating syndromes and anti–N‐methyl‐D‐aspartate receptor encephalitis | Annals of Neurology | 2014 | 405 |
| 14 | FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa | Biochemical and Biophysical Research Communications | 2004 | 401 |
| 15 | Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation | Human Molecular Genetics | 2006 | 386 |
| 16 | Coupling of bone resorption and formation by RANKL reverse signalling | Nature | 2018 | 376 |
| 17 | Concise Review: Notch Signaling in Stem Cell Systems | Stem Cells | 2006 | 370 |
| 18 | Spontaneous Intracranial Hemorrhage Caused by Brain Tumor | Neurosurgery | 1982 | 363 |
| 19 | Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography | Hepatology | 2009 | 363 |
| 20 | Prospective Trial of Stereotactic Body Radiation Therapy for Both Operable and Inoperable T1N0M0 Non-Small Cell Lung Cancer: Japan Clinical Oncology Group Study JCOG0403 | International Journal of Radiation Oncology Biology Physics | 2015 | 350 |
| 21 | Functional Analysis of PIK3CA Gene Mutations in Human Colorectal Cancer | Cancer Research | 2005 | 335 |
| 22 | Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population | Science Translational Medicine | 2009 | 334 |
| 23 | The Risk of Hemorrhage after Radiosurgery for Cerebral Arteriovenous Malformations | New England Journal of Medicine | 2005 | 331 |
| 24 | Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer | Nature Materials | 2005 | 330 |
| 25 | The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage | Arthritis and Rheumatism | 2004 | 322 |
| 26 | Ultraflexible, large-area, physiological temperature sensors for multipoint measurements | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 313 |
| 27 | Possible involvement of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism associated with renal insufficiency | American Journal of Kidney Diseases | 2004 | 294 |
| 28 | Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration | 2014 | 293 |
| 29 | Phenylboronic Acid-Installed Polymeric Micelles for Targeting Sialylated Epitopes in Solid Tumors | Journal of the American Chemical Society | 2013 | 286 |
| 30 | A microRNA regulatory mechanism of osteoblast differentiation | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 273 |
| 31 | Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity | Cell | 2012 | 271 |
| 32 | Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease | Nature Genetics | 2019 | 265 |
| 33 | Ghrelin Directly Regulates Bone Formation | Journal of Bone and Mineral Research | 2005 | 264 |
| 34 | Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Japanese Patients 60 Years or Older With Atherosclerotic Risk Factors | JAMA - Journal of the American Medical Association | 2014 | 257 |
| 35 | World‐Wide FINGERS Network: A global approach to risk reduction and prevention of dementia | Alzheimer's and Dementia | 2020 | 257 |
| 36 | Evi-1 Is a Critical Regulator for Hematopoietic Stem Cells and Transformed Leukemic Cells | Cell Stem Cell | 2008 | 252 |
| 37 | Thoracic and cardiovascular surgery in Japan during 2014 | General Thoracic and Cardiovascular Surgery | 2016 | 249 |
| 38 | Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy | Nature Genetics | 2018 | 238 |
| 39 | A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis | Journal of Bone and Mineral Research | 2018 | 229 |
| 40 | Therapeutic Effects of Anti-FGF23 Antibodies in Hypophosphatemic Rickets/Osteomalacia | Journal of Bone and Mineral Research | 2009 | 224 |
| 41 | Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease | Journal of Hepatology | 2011 | 217 |
| 42 | Clinical Course and Surgical Prognosis of 33 Cases of Intracranial Epidermoid Tumors | Neurosurgery | 1989 | 214 |
| 43 | Prediction of Sensitivity of Rectal Cancer Cells in Response to Preoperative Radiotherapy by DNA Microarray Analysis of Gene Expression Profiles | Cancer Research | 2006 | 212 |
| 44 | Malignant transformation of a vestibular schwannoma after gamma knife radiosurgery | Lancet, The | 2002 | 209 |
| 45 | Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance | Science Advances | 2016 | 209 |
| 46 | Impact of Expression of Human Epidermal Growth Factor Receptors EGFR and ERBB2 on Survival in Stage II/III Gastric Cancer | Clinical Cancer Research | 2012 | 201 |
| 47 | A Novel Mutation in Fibroblast Growth Factor 23 Gene as a Cause of Tumoral Calcinosis | Journal of Clinical Endocrinology and Metabolism | 2005 | 200 |
| 48 | Randomized, controlled trial of lateral node dissection vs. nerve-preserving resection in patients with rectal cancer after preoperative radiotherapy | Diseases of the Colon and Rectum | 2001 | 198 |
| 49 | Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis | Journal of Neurology, Neurosurgery and Psychiatry | 2012 | 192 |
| 50 | Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients | Bone | 2008 | 188 |
