| # | Title | Journal | Year | Citations |
|---|
| 1 | Cancer statistics in China, 2015 | Ca-A Cancer Journal for Clinicians | 2016 | 14,374 |
| 2 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial | Lancet, The | 2010 | 5,899 |
| 3 | Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial | Lancet, The | 2016 | 5,456 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 5 | Host-Gut Microbiota Metabolic Interactions | Science | 2012 | 3,693 |
| 6 | Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries | Lancet, The | 2018 | 3,228 |
| 7 | Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial | Lancet, The | 2017 | 3,224 |
| 8 | Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study | Lancet Oncology, The | 2010 | 2,093 |
| 9 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer) | Lancet, The | 2005 | 2,057 |
| 10 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2) | Lancet, The | 2015 | 1,863 |
| 11 | Cancer and Radiation Therapy: Current Advances and Future Directions | International Journal of Medical Sciences | 2012 | 1,686 |
| 12 | Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma | New England Journal of Medicine | 2018 | 1,443 |
| 13 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial | Lancet, The | 2012 | 1,422 |
| 14 | Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial | Lancet Oncology, The | 2016 | 1,344 |
| 15 | Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma | Journal of Hepatology | 2014 | 1,151 |
| 16 | Immune evasion in cancer: Mechanistic basis and therapeutic strategies | Seminars in Cancer Biology | 2015 | 1,122 |
| 17 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 18 | Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability | Genes and Development | 2000 | 1,087 |
| 19 | Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase III Study | Journal of Clinical Oncology | 2011 | 1,003 |
| 20 | Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial | Lancet Oncology, The | 2016 | 950 |
| 21 | Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis | Lancet, The | 2005 | 924 |
| 22 | Regulatory T cells in cancer immunosuppression — implications for anticancer therapy | Nature Reviews Clinical Oncology | 2019 | 872 |
| 23 | Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial | Lancet Oncology, The | 2010 | 852 |
| 24 | Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study | Lancet Oncology, The | 2013 | 849 |
| 25 | Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial | Lancet Oncology, The | 2014 | 849 |
| 26 | De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017 | Annals of Oncology | 2017 | 844 |
| 27 | Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study | Liver International | 2015 | 813 |
| 28 | External validation and comparison with other models of the International Metastatic Renal-Cell Carcinoma Database Consortium prognostic model: a population-based study | Lancet Oncology, The | 2013 | 808 |
| 29 | Mental health status of people isolated due to Middle East Respiratory Syndrome | Epidemiology and Health | 2016 | 801 |
| 30 | Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer | Nature Medicine | 2019 | 748 |
| 31 | Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial | Lancet Oncology, The | 2014 | 713 |
| 32 | Ultrasonography Diagnosis and Imaging-Based Management of Thyroid Nodules: Revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations | Korean Journal of Radiology | 2016 | 708 |
| 33 | Epidermal Growth Factor Receptor Gene Mutations and Increased Copy Numbers Predict Gefitinib Sensitivity in Patients With Recurrent Non–Small-Cell Lung Cancer | Journal of Clinical Oncology | 2005 | 701 |
| 34 | First-SIGNAL: First-Line Single-Agent Iressa Versus Gemcitabine and Cisplatin Trial in Never-Smokers With Adenocarcinoma of the Lung | Journal of Clinical Oncology | 2012 | 694 |
| 35 | Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study | Lancet Oncology, The | 2014 | 678 |
| 36 | Flat and depressed colonic neoplasms: a prospective study of 1000 colonoscopies in the UK | Lancet, The | 2000 | 674 |
| 37 | Polymorphism of human cytochrome P450 enzymes and its clinical impact | Drug Metabolism Reviews | 2009 | 671 |
| 38 | PD-1+regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 655 |
| 39 | Inhibition of Mouse Sarcoma 180 by Polysaccharides from Lentinus edodes (Berk.) Sing. | Nature | 1969 | 651 |
| 40 | Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial | Lancet Oncology, The | 2018 | 648 |
| 41 | Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer | Oncology Reports | 2015 | 621 |
| 42 | Randomized Trial of Radiotherapy Versus Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy in Patients With American Joint Committee on Cancer/International Union Against Cancer Stage III and IV Nasopharyngeal Cancer of the Endemic Variety | Journal of Clinical Oncology | 2005 | 596 |
| 43 | Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012 | Cancer Research and Treatment | 2015 | 595 |
| 44 | Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis | Cell | 2012 | 593 |
| 45 | Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis | Lancet Oncology, The | 2015 | 593 |
| 46 | Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study | Lancet Oncology, The | 2018 | 587 |
| 47 | Cancer survival in China, 2003–2005: A population‐based study | International Journal of Cancer | 2015 | 585 |
| 48 | Brain metastases | Nature Reviews Disease Primers | 2019 | 579 |
| 49 | Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish | Cancer Science | 2004 | 567 |
| 50 | Improved Quality of Life Outcomes After Laparoscopy-Assisted Distal Gastrectomy for Early Gastric Cancer | Annals of Surgery | 2008 | 566 |
