| # | Title | Journal | Year | Citations |
|---|
| 1 | Retinal repair by transplantation of photoreceptor precursors | Nature | 2006 | 999 |
| 2 | AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1 | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 756 |
| 3 | Predicting Successful Guidewire Crossing Through Chronic Total Occlusion of Native Coronary Lesions Within 30 Minutes | JACC: Cardiovascular Interventions | 2011 | 690 |
| 4 | Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice | Nature Medicine | 2003 | 606 |
| 5 | Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response | Gastroenterology | 2000 | 522 |
| 6 | Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus | Journal of Biological Chemistry | 1999 | 516 |
| 7 | Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 | EMBO Journal | 1999 | 509 |
| 8 | Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells | Journal of Experimental Medicine | 2005 | 481 |
| 9 | Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2−, Node-Positive, High-Risk, Early Breast Cancer (monarchE) | Journal of Clinical Oncology | 2020 | 478 |
| 10 | Age-related remodelling of oesophageal epithelia by mutated cancer drivers | Nature | 2019 | 476 |
| 11 | 2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection | American Journal of Transplantation | 2016 | 451 |
| 12 | Gene Expression Levels and Immunolocalization of Organic Ion Transporters in the Human Kidney | Journal of the American Society of Nephrology: JASN | 2002 | 450 |
| 13 | Human P-glycoprotein transports cyclosporin A and FK506 | Journal of Biological Chemistry | 1993 | 442 |
| 14 | Regulation of angiogenesis by hypoxia-inducible factor 1 | Critical Reviews in Oncology/Hematology | 2006 | 423 |
| 15 | Histopathologic Pattern and Clinical Features of Rheumatoid Arthritis-Associated Interstitial Lung Disease | Chest | 2005 | 406 |
| 16 | Cellular and molecular aspects of drug transport in the kidney | Kidney International | 2000 | 404 |
| 17 | Radiologic Manifestations of Sarcoidosis in Various Organs | Radiographics | 2004 | 402 |
| 18 | Lp(a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction | Atherosclerosis | 1986 | 400 |
| 19 | Esophageal cancer practice guidelines 2017 edited by the Japan Esophageal Society: part 1 | Esophagus | 2019 | 394 |
| 20 | Cancer prevention from the perspective of global cancer burden patterns | Journal of Thoracic Disease | 2017 | 379 |
| 21 | Validation of the IASLC/ATS/ERS Lung Adenocarcinoma Classification for Prognosis and Association with EGFR and KRAS Gene Mutations: Analysis of 440 Japanese Patients | Journal of Thoracic Oncology | 2013 | 374 |
| 22 | cDNA cloning and regional distribution of a novel member of the opioid receptor family | FEBS Letters | 1994 | 373 |
| 23 | Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H+-organic cation antiporters | Biochemical Pharmacology | 2007 | 369 |
| 24 | Stent Thrombosis | Journal of the American College of Cardiology | 2010 | 363 |
| 25 | PD-1–PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma | Blood | 2008 | 362 |
| 26 | Rapid Ventricular Induction of Brain Natriuretic Peptide Gene Expression in Experimental Acute Myocardial Infarction | Circulation | 1995 | 356 |
| 27 | A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer | Cancer Chemotherapy and Pharmacology | 2011 | 350 |
| 28 | Significance of Pulmonary Arterial Pressure and Diffusion Capacity of the Lung as Prognosticator in Patients With Idiopathic Pulmonary Fibrosis | Chest | 2007 | 349 |
| 29 | Identification and Functional Characterization of a New Human Kidney–Specific H+/Organic Cation Antiporter, Kidney-Specific Multidrug and Toxin Extrusion 2 | Journal of the American Society of Nephrology: JASN | 2006 | 348 |
| 30 | Three distinct subpopulations of GABAergic neurons in rat frontal agranular cortex | Brain Research | 1994 | 342 |
| 31 | Autoimmune related pancreatitis | Gut | 2002 | 339 |
| 32 | Lymph Node Fibroblastic Reticular Cells Construct the Stromal Reticulum via Contact with Lymphocytes | Journal of Experimental Medicine | 2004 | 339 |
| 33 | cDNA Cloning and Functional Expression of a Novel Rat Kidney Organic Cation Transporter, OCT2 | Biochemical and Biophysical Research Communications | 1996 | 335 |
| 34 | Pulmonary Manifestations of Primary Sjögren's Syndrome | American Journal of Respiratory and Critical Care Medicine | 2005 | 324 |
| 35 | JCS 2018 Guideline on Diagnosis and Treatment of Acute Coronary Syndrome | Circulation Journal | 2019 | 324 |
| 36 | Complexity of terminal airspace geometry assessed by lung computed tomography in normal subjects and patients with chronic obstructive pulmonary disease | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 321 |
| 37 | Esophageal cancer practice guidelines 2017 edited by the Japan esophageal society: part 2 | Esophagus | 2019 | 321 |
| 38 | Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and caucasian patients | Journal of the American College of Cardiology | 1999 | 318 |
| 39 | Everolimus-eluting bioresorbable vascular scaffolds versus everolimus-eluting metallic stents: a meta-analysis of randomised controlled trials | Lancet, The | 2016 | 317 |
| 40 | Metformin is a Superior Substrate for Renal Organic Cation Transporter OCT2 rather than Hepatic OCT1 | Drug Metabolism and Pharmacokinetics | 2005 | 313 |
| 41 | Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma | Journal of Gastroenterology | 2009 | 313 |
| 42 | Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 310 |
| 43 | Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 310 |
| 44 | A High Glycolytic Flux Supports the Proliferative Potential of Murine Embryonic Stem Cells | Antioxidants and Redox Signaling | 2007 | 302 |
| 45 | Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family) | Journal of Pharmacology and Experimental Therapeutics | 2006 | 300 |
| 46 | Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: An analysis of Japan Multinational Trial Organisation LC00-03 | European Journal of Cancer | 2009 | 300 |
| 47 | Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia | American Heart Journal | 2008 | 296 |
| 48 | Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria | Modern Pathology | 2007 | 271 |
| 49 | The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas | European Radiology | 2008 | 268 |
| 50 | A new cell-permeable peptide allows successful allogeneic islet transplantation in mice | Nature Medicine | 2004 | 264 |
