| # | Title | Journal | Year | Citations |
|---|
| 1 | Transfusion Strategies for Acute Upper Gastrointestinal Bleeding | New England Journal of Medicine | 2013 | 1,468 |
| 2 | The structure of histone H1 and its location in chromatin | Nature | 1980 | 710 |
| 3 | Chronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications | Journal of Clinical Endocrinology and Metabolism | 2001 | 705 |
| 4 | Excessive Daytime Sleepiness in a General Population Sample: The Role of Sleep Apnea, Age, Obesity, Diabetes, and Depression | Journal of Clinical Endocrinology and Metabolism | 2005 | 629 |
| 5 | Insomnia with Objective Short Sleep Duration is Associated with a High Risk for Hypertension | Sleep | 2009 | 629 |
| 6 | Negative consequences from heavy social networking in adolescents: The mediating role of fear of missing out | Journal of Adolescence | 2017 | 474 |
| 7 | Increased mucosal tumour necrosis factor alpha production in Crohn's disease can be downregulated ex vivo by probiotic bacteria | Gut | 2002 | 278 |
| 8 | Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism. | Journal of Clinical Endocrinology and Metabolism | 1993 | 260 |
| 9 | Acute Hemodynamic Response to β-Blockers and Prediction of Long-term Outcome in Primary Prophylaxis of Variceal Bleeding | Gastroenterology | 2009 | 207 |
| 10 | Insomnia with Objective Short Sleep Duration is Associated with Deficits in Neuropsychological Performance: A General Population Study | Sleep | 2010 | 196 |
| 11 | Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer | Oncogene | 2003 | 195 |
| 12 | Approach to the Pathogenesis and Treatment of Nonalcoholic Steatohepatitis | Diabetes Care | 2004 | 193 |
| 13 | Short sleep duration and obesity: the role of emotional stress and sleep disturbances | International Journal of Obesity | 2008 | 191 |
| 14 | Chronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications | Journal of Clinical Endocrinology and Metabolism | 2001 | 159 |
| 15 | Chronic lymphocytic leukaemia: from genetics to treatment | Nature Reviews Clinical Oncology | 2019 | 154 |
| 16 | Acromegaly Quality of Life Questionnaire (ACROQOL) a new health‐related quality of life questionnaire for patients with acromegaly: development and psychometric properties | Clinical Endocrinology | 2002 | 151 |
| 17 | Multilocular Cystic Renal Cell Carcinoma | American Journal of Clinical Pathology | 2006 | 148 |
| 18 | Multiple Endocrine Abnormalities of the Growth Hormone and Insulin-Like Growth Factor Axis in Patients with Anorexia Nervosa: Effect of Short- and Long-Term Weight Recuperation1 | Journal of Clinical Endocrinology and Metabolism | 1997 | 144 |
| 19 | Cell therapy using bone marrow stromal cells in chronic paraplegic rats: Systemic or local administration? | Neuroscience Letters | 2006 | 138 |
| 20 | Cavernomas of the central nervous system: Clinical syndromes, CT scan diagnosis, and prognosis after surgical treatment in 25 cases | Acta Neurochirurgica | 1987 | 135 |
| 21 | Rationale for combination of therapeutic antibodies targeting tumor cells and immune checkpoint receptors: Harnessing innate and adaptive immunity through IgG1 isotype immune effector stimulation | Cancer Treatment Reviews | 2018 | 134 |
| 22 | Relationship Between Bone Quantitative Ultrasound and Fractures: A Meta-Analysis | Journal of Bone and Mineral Research | 2006 | 130 |
| 23 | Maturation of the lower esophagus | Journal of Pediatric Surgery | 1976 | 129 |
| 24 | Women sleep objectively better than men and the sleep of young women is more resilient to external stressors: effects of age and menopause | Journal of Sleep Research | 2009 | 128 |
| 25 | Novel (60%) and Recurrent (40%) Androgen Receptor Gene Mutations in a Series of 59 Patients with a 46,XY Disorder of Sex Development | Journal of Clinical Endocrinology and Metabolism | 2010 | 127 |
| 26 | Systematic review: infliximab therapy in ulcerative colitis | Alimentary Pharmacology and Therapeutics | 2007 | 125 |
| 27 | Functional recovery in chronic paraplegia after bone marrow stromal cells transplantation | NeuroReport | 2004 | 124 |
| 28 | Multiple Endocrine Abnormalities of the Growth Hormone and Insulin-Like Growth Factor Axis in Prepubertal Children with Exogenous Obesity: Effect of Short- and Long-Term Weight Reduction1 | Journal of Clinical Endocrinology and Metabolism | 1997 | 121 |
| 29 | Natural history of premature pubarche: an auxological study. | Journal of Clinical Endocrinology and Metabolism | 1992 | 115 |
| 30 | Head and Neck Paragangliomas in Von Hippel-Lindau Disease and Multiple Endocrine Neoplasia Type 2 | Journal of Clinical Endocrinology and Metabolism | 2009 | 112 |
| 31 | Ultrastructure of the aging human testis | Journal of Electron Microscopy Technique | 1991 | 111 |
| 32 | Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enhances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis | Journal of Immunology | 2009 | 108 |
| 33 | Ten Novel Mutations in the NR5A1 Gene Cause Disordered Sex Development in 46,XY and Ovarian Insufficiency in 46,XX Individuals | Journal of Clinical Endocrinology and Metabolism | 2012 | 108 |
| 34 | Leptin Impairs Insulin Signaling in Rat Adipocytes | Diabetes | 2004 | 107 |
| 35 | Idiopathic Facial Paralysis: A Randomized, Prospective, and Controlled Study Using Single-Dose Prednisone Versus Acyclovir Three Times Daily | Laryngoscope | 1998 | 106 |
| 36 | Syringomyelia-Chiari complex: magnetic resonance imaging and clinical evaluation of surgical treatment | Journal of Neurosurgery | 1990 | 104 |
| 37 | Cavernomas of the Brain | Neurosurgery | 1983 | 103 |
| 38 | Long-term food restriction prevents ageing-associated central leptin resistance in wistar rats | Diabetologia | 2002 | 102 |
| 39 | Drugs plus ligation to prevent rebleeding in cirrhosis: an updated systematic review | Liver International | 2014 | 102 |
| 40 | Hyperinsulinemia in postpubertal girls with a history of premature pubarche and functional ovarian hyperandrogenism. | Journal of Clinical Endocrinology and Metabolism | 1996 | 101 |
| 41 | Repeated subarachnoid administrations of autologous mesenchymal stromal cells supported in autologous plasma improve quality of life in patients suffering incomplete spinal cord injury | Cytotherapy | 2017 | 99 |
| 42 | Tissue-Specific Effects of Central Leptin on the Expression of Genes Involved in Lipid Metabolism in Liver and White Adipose Tissue | Endocrinology | 2007 | 96 |
| 43 | Multicenter Spanish study of spectral‐domain optical coherence tomography in normal children | Acta Ophthalmologica | 2013 | 95 |
| 44 | Leptin plasma levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosa | Journal of Pediatrics | 1997 | 94 |
| 45 | Hysteresis loop construction for the metal-semiconductor phase transition in vanadium dioxide films | Technical Physics | 2002 | 94 |
| 46 | Interleukin-10 and the Monocyte/Macrophage-Induced Inflammatory Response in Septic Shock | Journal of Infectious Diseases | 1995 | 90 |
| 47 | Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients: an expert taskforce review | Annals of Oncology | 2017 | 89 |
| 48 | Use of leuprolide acetate response patterns in the early diagnosis of pubertal disorders: comparison with the gonadotropin-releasing hormone test. | Journal of Clinical Endocrinology and Metabolism | 1994 | 87 |
| 49 | Ageing increases SOCS-3 expression in rat hypothalamus: effects of food restriction | Biochemical and Biophysical Research Communications | 2002 | 87 |
| 50 | Bone Mineral Density in Prepubertal and in Adolescent and Young Adult Patients With the Salt-wasting Form of Congenital Adrenal Hyperplasia | Pediatrics | 1997 | 86 |
