| # | Title | Journal | Year | Citations |
|---|
| 1 | Artificial intelligence in healthcare: past, present and future | Stroke and Vascular Neurology | 2017 | 2,009 |
| 2 | Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction | Angewandte Chemie - International Edition | 2016 | 930 |
| 3 | The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2 | Cardiovascular Research | 2020 | 912 |
| 4 | MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis | Nature Immunology | 2009 | 726 |
| 5 | Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients | Chinese Medical Journal | 2020 | 686 |
| 6 | Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway | Trends in Molecular Medicine | 2015 | 628 |
| 7 | Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance | Lancet Infectious Diseases, The | 2021 | 586 |
| 8 | Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China | JAMA - Journal of the American Medical Association | 2015 | 577 |
| 9 | Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis | Science | 2011 | 475 |
| 10 | Antiferromagnetic Pyrite as the Tumor Microenvironment‐Mediated Nanoplatform for Self‐Enhanced Tumor Imaging and Therapy | Advanced Materials | 2017 | 458 |
| 11 | CGCG clinical practice guidelines for the management of adult diffuse gliomas | Cancer Letters | 2016 | 448 |
| 12 | Plasmid-Mediated Quinolone Resistance in Clinical Isolates of Escherichia coli from Shanghai, China | Antimicrobial Agents and Chemotherapy | 2003 | 423 |
| 13 | Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia | Nature Genetics | 2011 | 416 |
| 14 | Cerebral Micro-Structural Changes in COVID-19 Patients – An MRI-based 3-month Follow-up Study | EClinicalMedicine | 2020 | 405 |
| 15 | The cost of Alzheimer's disease in China and re‐estimation of costs worldwide | Alzheimer's and Dementia | 2018 | 404 |
| 16 | Epithelial–mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis | Journal of Cellular Physiology | 2017 | 391 |
| 17 | Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 354 |
| 18 | An open science resource for establishing reliability and reproducibility in functional connectomics | Scientific Data | 2014 | 349 |
| 19 | Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer | Nature | 2018 | 327 |
| 20 | Proportion of asymptomatic coronavirus disease 2019: A systematic review and meta‐analysis | Journal of Medical Virology | 2021 | 321 |
| 21 | CLINICAL EVALUATION AND FOLLOW-UP OUTCOME OF DIFFUSION TENSOR IMAGING-BASED FUNCTIONAL NEURONAVIGATION | Neurosurgery | 2007 | 320 |
| 22 | Widespread and Functional RNA Circularization in Localized Prostate Cancer | Cell | 2019 | 317 |
| 23 | GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 316 |
| 24 | Association between age and clinical characteristics and outcomes of COVID-19 | European Respiratory Journal | 2020 | 316 |
| 25 | Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies | Ageing Research Reviews | 2019 | 314 |
| 26 | China Stroke Statistics 2019: A Report From the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations | Stroke and Vascular Neurology | 2020 | 313 |
| 27 | Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids | Protein and Cell | 2020 | 313 |
| 28 | Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study | Lancet Neurology, The | 2008 | 310 |
| 29 | Clinical observation and management of COVID-19 patients | Emerging Microbes and Infections | 2020 | 306 |
| 30 | Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells | Clinical Cancer Research | 2009 | 297 |
| 31 | Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System | Neuron | 2018 | 292 |
| 32 | Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles | CheM | 2019 | 288 |
| 33 | New Plasmid-Mediated Quinolone Resistance Gene, qnrC , Found in a Clinical Isolate of Proteus mirabilis | Antimicrobial Agents and Chemotherapy | 2009 | 279 |
| 34 | Dual-Targeting Upconversion Nanoprobes across the Blood–Brain Barrier for Magnetic Resonance/Fluorescence Imaging of Intracranial Glioblastoma | ACS Nano | 2014 | 279 |
| 35 | Magnetic nanoparticle clusters for photothermal therapy with near-infrared irradiation | Biomaterials | 2015 | 277 |
| 36 | LncRNA PVT1 promotes angiogenesis via activating the STAT3/VEGFA axis in gastric cancer | Oncogene | 2018 | 275 |
| 37 | Resistance trends among clinical isolates in China reported from CHINET surveillance of bacterial resistance, 2005–2014 | Clinical Microbiology and Infection | 2016 | 274 |
| 38 | miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development | PLoS ONE | 2013 | 270 |
| 39 | Recurrent gain-of-function USP8 mutations in Cushing's disease | Cell Research | 2015 | 263 |
| 40 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers | Cell Research | 2017 | 262 |
| 41 | Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma | Nature Genetics | 2013 | 259 |
| 42 | Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials | Journal of Neurology, Neurosurgery and Psychiatry | 2020 | 258 |
| 43 | Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death | European Urology | 2017 | 256 |
| 44 | Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease | Brain | 2020 | 255 |
| 45 | BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 254 |
| 46 | The progress of gut microbiome research related to brain disorders | Journal of Neuroinflammation | 2020 | 252 |
| 47 | Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade | Gut | 2019 | 246 |
| 48 | Faecalibacterium prausnitzii Produces Butyrate to Maintain Th17/Treg Balance and to Ameliorate Colorectal Colitis by Inhibiting Histone Deacetylase 1 | Inflammatory Bowel Diseases | 2018 | 245 |
| 49 | Nanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy | Biomaterials | 2019 | 243 |
| 50 | MRSA epidemic linked to a quickly spreading colonization and virulence determinant | Nature Medicine | 2012 | 242 |
