| # | Title | Journal | Year | Citations |
|---|
| 1 | Prevention of Venous Thromboembolism | Chest | 2008 | 3,752 |
| 2 | Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood | Nature Medicine | 2007 | 1,928 |
| 3 | Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions | Intensive Care Medicine | 2006 | 1,507 |
| 4 | The Epidemiology of Wound Infection: A 10-Year Prospective Study of 62,939 Wounds | Surgical Clinics of North America | 1980 | 1,256 |
| 5 | A depression rating scale for schizophrenics | Schizophrenia Research | 1990 | 1,090 |
| 6 | Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial | Lancet Oncology, The | 2017 | 776 |
| 7 | Low Rates of Acute Recanalization With Intravenous Recombinant Tissue Plasminogen Activator in Ischemic Stroke | Stroke | 2010 | 638 |
| 8 | Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke | American Journal of Neuroradiology | 2001 | 583 |
| 9 | Reliability and validity of a depression rating scale for schizophrenics | Schizophrenia Research | 1992 | 570 |
| 10 | Likelihood ratios for a sleep apnea clinical prediction rule. | American Journal of Respiratory and Critical Care Medicine | 1994 | 439 |
| 11 | Characterizing quality of life among patients with chronic mental illness: a critical examination of the self-report methodology | American Journal of Psychiatry | 1997 | 414 |
| 12 | Facial affect recognition and information processing in schizophrenia and bipolar disorder | Schizophrenia Research | 1998 | 407 |
| 13 | Air Pollution and Brain Damage | Toxicologic Pathology | 2002 | 404 |
| 14 | Propofol vs Midazolam for ICU Sedation | Chest | 2001 | 402 |
| 15 | Impact of anemia on hospitalization and mortality in older adults | Blood | 2006 | 352 |
| 16 | A randomized trial comparing primary angioplasty with a strategy of short-acting thrombolysis and immediate planned rescue angioplasty in acute myocardial infarction: the PACT trial | Journal of the American College of Cardiology | 1999 | 351 |
| 17 | Extended-Duration Venous Thromboembolism Prophylaxis in Acutely Ill Medical Patients With Recently Reduced Mobility | Annals of Internal Medicine | 2010 | 341 |
| 18 | Diagnostic reasoning strategies and diagnostic success | Medical Education | 2003 | 314 |
| 19 | Anaesthesia and emesis. I: Etiology | Canadian Anaesthetists' Society Journal | 1984 | 299 |
| 20 | A phase II study of preoperative chemotherapy and radiation therapy followed by esophagectomy in localized esophageal carcinoma | International Journal of Radiation Oncology Biology Physics | 2001 | 287 |
| 21 | Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data | Lancet Neurology, The | 2018 | 281 |
| 22 | Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke | Lancet Neurology, The | 2015 | 280 |
| 23 | Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data | Lancet Neurology, The | 2019 | 276 |
| 24 | Canadian spontaneous coronary artery dissection cohort study: in-hospital and 30-day outcomes | European Heart Journal | 2019 | 275 |
| 25 | Extended Out-of-Hospital Low-Molecular-Weight Heparin Prophylaxis against Deep Venous Thrombosis in Patients after Elective Hip Arthroplasty | Annals of Internal Medicine | 2001 | 271 |
| 26 | Predictors of late development of heart failure in stable survivors of myocardial infarction | Journal of the American College of Cardiology | 2003 | 271 |
| 27 | Aspirin Versus Aspirin Plus Clopidogrel as Antithrombotic Treatment Following Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve | JACC: Cardiovascular Interventions | 2017 | 264 |
| 28 | Selection of Acute Ischemic Stroke Patients for Intra-Arterial Thrombolysis With Pro-Urokinase by Using ASPECTS | Stroke | 2003 | 262 |
| 29 | eTICI reperfusion: defining success in endovascular stroke therapy | Journal of NeuroInterventional Surgery | 2019 | 251 |
| 30 | Prevention of NSAID-induced gastroduodenal ulcers | The Cochrane Library | 2002 | 250 |
| 31 | Low-Molecular-Weight Heparin Prophylaxis Using Dalteparin in Close Proximity to Surgery vs Warfarin in Hip Arthroplasty Patients | Archives of Internal Medicine | 2000 | 244 |
| 32 | Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF121 (AdVEGF121) versus maximum medical treatment | Gene Therapy | 2006 | 244 |
| 33 | Application of shape analysis to mammographic calcifications | IEEE Transactions on Medical Imaging | 1994 | 241 |
| 34 | Myocardial infarction patients in the 1990s—their risk factors, stratification and survival in Canada: The Canadian assessment of myocardial infarction (CAMI) study | Journal of the American College of Cardiology | 1996 | 241 |
| 35 | Epidemiology of Sporadic Diarrhea Due to Verocytotoxin-Producing Escherichia coli: A Two-Year Prospective Study | Journal of Infectious Diseases | 1988 | 232 |
| 36 | Neurocognitive and social functioning in schizophrenia: a 2.5 year follow-up study | Schizophrenia Research | 2000 | 230 |
| 37 | Specificity of the Calgary Depression Scale for schizophrenics | Schizophrenia Research | 1994 | 229 |
| 38 | Combined Seton Placement, Infliximab Infusion, and Maintenance Immunosuppressives Improve Healing Rate in Fistulizing Anorectal Crohn's Disease | Diseases of the Colon and Rectum | 2003 | 227 |
| 39 | Relationship between EMG patterns and kinematic properties for flexion movements at the human wrist | Experimental Brain Research | 1987 | 224 |
| 40 | Tailored prophylaxis in severe hemophilia A: interim results from the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study | Journal of Thrombosis and Haemostasis | 2006 | 224 |
| 41 | Prolonged but Delayed Postischemic Hypothermia: A Long-term Outcome Study in the Rat Middle Cerebral Artery Occlusion Model | Journal of Cerebral Blood Flow and Metabolism | 2000 | 210 |
| 42 | Sudden death in patients with implantable cardioverter defibrillators | Journal of the American College of Cardiology | 2002 | 208 |
| 43 | Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data | Lancet Neurology, The | 2018 | 205 |
| 44 | Uterine rupture during induced trial of labor among women with previous cesarean delivery | American Journal of Obstetrics and Gynecology | 2000 | 196 |
| 45 | A new look at toxic megacolon: an update and review of incidence, etiology, pathogenesis, and management | American Journal of Gastroenterology | 2003 | 196 |
| 46 | A psychometric comparison of the Calgary depression scale for schizophrenia and the Hamilton depression rating scale | Schizophrenia Research | 1996 | 193 |
| 47 | Are lipid-lowering drugs also antiarrhythmic drugs? | Journal of the American College of Cardiology | 2003 | 193 |
| 48 | Homozygous Deletion of the Very Low Density Lipoprotein Receptor Gene Causes Autosomal Recessive Cerebellar Hypoplasia with Cerebral Gyral Simplification | American Journal of Human Genetics | 2005 | 192 |
| 49 | Low-Molecular-Weight Heparin Prophylaxis Using Dalteparin Extended Out-of-Hospital vs In-Hospital Warfarin/Out-of-Hospital Placebo in Hip Arthroplasty Patients | Archives of Internal Medicine | 2000 | 183 |
| 50 | Baseline stress myocardial perfusion imaging results and outcomes in patients with stable ischemic heart disease randomized to optimal medical therapy with or without percutaneous coronary intervention | American Heart Journal | 2012 | 175 |
