| # | Title | Journal | Year | Citations |
|---|
| 1 | Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome | Critical Care Medicine | 1999 | 1,304 |
| 2 | Oncogenes and Cancer | New England Journal of Medicine | 2008 | 898 |
| 3 | Expression profiling identifies microRNA signature in pancreatic cancer | International Journal of Cancer | 2006 | 800 |
| 4 | Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients* | Critical Care Medicine | 2007 | 725 |
| 5 | Fragile X Premutation Tremor/Ataxia Syndrome: Molecular, Clinical, and Neuroimaging Correlates | American Journal of Human Genetics | 2003 | 720 |
| 6 | Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome | Critical Care Medicine | 2003 | 716 |
| 7 | microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma | Cancer Research | 2008 | 705 |
| 8 | Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial | Lancet, The | 2014 | 689 |
| 9 | miR-221 overexpression contributes to liver tumorigenesis | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 679 |
| 10 | Non-small-cell lung cancer | Nature Reviews Disease Primers | 2015 | 653 |
| 11 | Cabozantinib Versus Sunitinib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma of Poor or Intermediate Risk: The Alliance A031203 CABOSUN Trial | Journal of Clinical Oncology | 2017 | 584 |
| 12 | Impact of Oophorectomy on Cancer Incidence and Mortality in Women With a BRCA1 or BRCA2 Mutation | Journal of Clinical Oncology | 2014 | 523 |
| 13 | Consensus Guidelines for the Management and Treatment of Neuroendocrine Tumors | Pancreas | 2013 | 494 |
| 14 | Implementing genomic medicine in the clinic: the future is here | Genetics in Medicine | 2013 | 472 |
| 15 | Review of Current Evidence for Apoptosis After Spinal Cord Injury | Journal of Neurotrauma | 2000 | 461 |
| 16 | The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline | Journal of Neuro-Oncology | 2010 | 446 |
| 17 | Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial | Lancet Respiratory Medicine,the | 2019 | 443 |
| 18 | Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240) | Lancet, The | 2017 | 424 |
| 19 | Mifepristone, a Glucocorticoid Receptor Antagonist, Produces Clinical and Metabolic Benefits in Patients with Cushing's Syndrome | Journal of Clinical Endocrinology and Metabolism | 2012 | 409 |
| 20 | Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake | Nature Neuroscience | 2013 | 408 |
| 21 | Adult Starvation and Disease‐Related Malnutrition | Journal of Parenteral and Enteral Nutrition | 2010 | 397 |
| 22 | Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2011 | 370 |
| 23 | Effects of Intensive BP Control in CKD | Journal of the American Society of Nephrology: JASN | 2017 | 364 |
| 24 | The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline | Journal of Neuro-Oncology | 2010 | 361 |
| 25 | Prevalence of Chondral Defects in Athletes' Knees | Medicine and Science in Sports and Exercise | 2010 | 351 |
| 26 | FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene | Cell | 2007 | 350 |
| 27 | Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 328 |
| 28 | Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: a retrospective analysis | Lancet Oncology, The | 2016 | 318 |
| 29 | Modulation of mismatch repair and genomic stability by miR-155 | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 306 |
| 30 | Temporal relationship of atrial tachyarrhythmias, cerebrovascular events, and systemic emboli based on stored device data: A subgroup analysis of TRENDS | Heart Rhythm | 2011 | 296 |
| 31 | Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung | Inflammopharmacology | 2009 | 294 |
| 32 | Biliary cancer: Utility of next‐generation sequencing for clinical management | Cancer | 2016 | 289 |
| 33 | Clinical Study of the Laser Sheath for Lead Extraction: The Total Experience in the United States | PACE - Pacing and Clinical Electrophysiology | 2002 | 283 |
| 34 | The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline | Journal of Neuro-Oncology | 2010 | 283 |
| 35 | Safe Practices for Parenteral Nutrition | Journal of Parenteral and Enteral Nutrition | 2004 | 282 |
| 36 | Timing of Prenatal Stressors and Autism | Journal of Autism and Developmental Disorders | 2005 | 281 |
| 37 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline | Journal of Neuro-Oncology | 2010 | 277 |
| 38 | THE LONG-TERM FOLLOWUP OF NEWBORNS WITH SEVERE UNILATERAL HYDRONEPHROSIS INITIALLY TREATED NONOPERATIVELY | Journal of Urology | 2000 | 273 |
| 39 | The miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog–Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehog–Treated Cerebellar Neural Precursors | Cancer Research | 2009 | 273 |
| 40 | Bacteremia with Streptococcus pneumoniae. Implications for therapy and prevention. Franklin County Pneumonia Study Group | JAMA - Journal of the American Medical Association | 1996 | 259 |
| 41 | T-bet is essential for encephalitogenicity of both Th1 and Th17 cells | Journal of Experimental Medicine | 2009 | 253 |
| 42 | Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 250 |
| 43 | Angiographic assessment of pial collaterals as a prognostic indicator following intra-arterial thrombolysis for acute ischemic stroke | American Journal of Neuroradiology | 2005 | 247 |
| 44 | Orthopedic outcomes of long-term daily corticosteroid treatment in Duchenne muscular dystrophy | Neurology | 2007 | 238 |
| 45 | Factors that influence adherence with disease-modifying therapy in MS | Journal of Neurology | 2009 | 238 |
| 46 | Roles of small RNAs in tumor formation | Trends in Molecular Medicine | 2010 | 236 |
| 47 | A Distal Axonal Cytoskeleton Forms an Intra-Axonal Boundary that Controls Axon Initial Segment Assembly | Cell | 2012 | 230 |
| 48 | PREVENtion of HeartMate II Pump Thrombosis Through Clinical Management: The PREVENT multi-center study | Journal of Heart and Lung Transplantation | 2017 | 229 |
| 49 | Loss of Parafibromin Immunoreactivity Is a Distinguishing Feature of Parathyroid Carcinoma | Clinical Cancer Research | 2004 | 223 |
| 50 | Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy: Results of the adaptive CRT trial | Heart Rhythm | 2012 | 223 |
