| # | Title | Journal | Year | Citations |
|---|
| 1 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 2 | Prevalence of Age-Related Macular Degeneration in the United States | JAMA Ophthalmology | 2004 | 2,397 |
| 3 | COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up | Journal of the American College of Cardiology | 2020 | 2,392 |
| 4 | Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC | New England Journal of Medicine | 2018 | 2,150 |
| 5 | The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years | Movement Disorders | 2008 | 1,779 |
| 6 | Phenomenology and classification of dystonia: A consensus update | Movement Disorders | 2013 | 1,754 |
| 7 | The Natural History of Chronic Allograft Nephropathy | New England Journal of Medicine | 2003 | 1,748 |
| 8 | Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions | American Journal of Transplantation | 2008 | 1,710 |
| 9 | Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set | Microbiology (United Kingdom) | 2002 | 1,683 |
| 10 | Pembrolizumab for Early Triple-Negative Breast Cancer | New England Journal of Medicine | 2020 | 1,542 |
| 11 | PPARγ signaling and metabolism: the good, the bad and the future | Nature Medicine | 2013 | 1,526 |
| 12 | Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium | Clinical Infectious Diseases | 2020 | 1,429 |
| 13 | Variability of Blood Glucose Concentration and Short-term Mortality in Critically Ill Patients | Anesthesiology | 2006 | 1,305 |
| 14 | Whole–genome characterization of chemoresistant ovarian cancer | Nature | 2015 | 1,206 |
| 15 | Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients | Science | 1995 | 1,178 |
| 16 | Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non–Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50% or Greater | Journal of Clinical Oncology | 2019 | 1,144 |
| 17 | Cooling for newborns with hypoxic ischaemic encephalopathy | The Cochrane Library | 2013 | 1,088 |
| 18 | Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor | Journal of Thrombosis and Haemostasis | 2006 | 1,061 |
| 19 | Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium | Lancet Infectious Diseases, The | 2019 | 970 |
| 20 | NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome | Hepatology | 2002 | 967 |
| 21 | Sydney multicenter study of Parkinson's disease: Non‐ L ‐dopa–responsive problems dominate at 15 years | Movement Disorders | 2005 | 967 |
| 22 | Prognostic and Clinicopathologic Associations of Oncogenic BRAF in Metastatic Melanoma | Journal of Clinical Oncology | 2011 | 942 |
| 23 | Beyond insulin resistance in NASH: TNF-? or adiponectin? | Hepatology | 2004 | 928 |
| 24 | PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily | Science | 1990 | 918 |
| 25 | Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy | Cell | 2014 | 871 |
| 26 | Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β | Nature | 2012 | 867 |
| 27 | Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial | Lancet, The | 2012 | 856 |
| 28 | Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy | Cancer Discovery | 2014 | 836 |
| 29 | Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline | Endoscopy | 2017 | 831 |
| 30 | The relationship between glaucoma and myopia | Ophthalmology | 1999 | 827 |
| 31 | The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell–mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials | American Journal of Transplantation | 2018 | 813 |
| 32 | Five-Year Overall Survival for Patients With Advanced Non‒Small-Cell Lung Cancer Treated With Pembrolizumab: Results From the Phase I KEYNOTE-001 Study | Journal of Clinical Oncology | 2019 | 811 |
| 33 | The metabolic syndrome in children and adolescents | Lancet, The | 2007 | 776 |
| 34 | Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial | Lancet Oncology, The | 2017 | 776 |
| 35 | Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis | Annals of Neurology | 2011 | 751 |
| 36 | Physiological Action of Progesterone in Target Tissues* | Endocrine Reviews | 1997 | 700 |
| 37 | Banff ’09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Groups | American Journal of Transplantation | 2010 | 691 |
| 38 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression | Gastroenterology | 2003 | 681 |
| 39 | Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA and Non-HLA Antibodies in Transplantation | Transplantation | 2013 | 679 |
| 40 | KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary | Kidney International | 2010 | 675 |
| 41 | Improvement in Outcomes of Clinical Islet Transplantation: 1999–2010 | Diabetes Care | 2012 | 665 |
| 42 | Fetal umbilical artery flow velocity waveforms and placental resistance: pathological correlation | BJOG: an International Journal of Obstetrics and Gynaecology | 1985 | 647 |
| 43 | Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001 | Annals of Oncology | 2019 | 641 |
| 44 | Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary | Journal of Pathology | 2010 | 617 |
| 45 | Fibroblasts Can Be Genetically Modified to Produce Excitable Cells Capable of Electrical Coupling | Circulation | 2005 | 614 |
| 46 | Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3 | Journal of Experimental Medicine | 2008 | 610 |
| 47 | Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus | Arthritis and Rheumatism | 2010 | 593 |
| 48 | Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1 | Nature Genetics | 2013 | 589 |
| 49 | Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial | Lancet Oncology, The | 2012 | 584 |
| 50 | Mobile Telephone Text Messaging for Medication Adherence in Chronic Disease | JAMA Internal Medicine | 2016 | 580 |
