| # | Title | Journal | Year | Citations |
|---|
| 1 | Epigenetic programming by maternal behavior | Nature Neuroscience | 2004 | 5,564 |
| 2 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 3 | A simple technique for demonstrating centromeric heterochromatin | Experimental Cell Research | 1972 | 3,936 |
| 4 | Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Nature | 1995 | 3,894 |
| 5 | Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK | Lancet, The | 2021 | 3,887 |
| 6 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 7 | MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis | Lancet, The | 1991 | 3,310 |
| 8 | New Giemsa method for the differential staining of sister chromatids | Nature | 1974 | 3,119 |
| 9 | Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors | Science | 1992 | 3,065 |
| 10 | Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology | Canadian Journal of Gastroenterology & Hepatology | 2005 | 2,711 |
| 11 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 12 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 13 | A new variant of Creutzfeldt-Jakob disease in the UK | Lancet, The | 1996 | 2,554 |
| 14 | Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain | Nature | 2001 | 2,535 |
| 15 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
| 16 | The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications | Gut | 2006 | 2,362 |
| 17 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
| 18 | Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent | Nature | 1997 | 1,861 |
| 19 | ESPEN guidelines on nutrition in cancer patients | Clinical Nutrition | 2017 | 1,855 |
| 20 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 21 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 22 | Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD | Nature | 1996 | 1,649 |
| 23 | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | Nature Genetics | 2010 | 1,631 |
| 24 | Telomere reduction in human colorectal carcinoma and with ageing | Nature | 1990 | 1,612 |
| 25 | Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial | Lancet, The | 2016 | 1,570 |
| 26 | Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer | Nature | 1994 | 1,523 |
| 27 | Cerebral microbleeds: a guide to detection and interpretation | Lancet Neurology, The | 2009 | 1,503 |
| 28 | COLLAGEN SUBSTRATA FOR STUDIES ON CELL BEHAVIOR | Journal of Cell Biology | 1972 | 1,441 |
| 29 | Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans | Nature | 2009 | 1,405 |
| 30 | A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome | Nature Genetics | 2001 | 1,401 |
| 31 | European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement | Journal of Hypertension | 2003 | 1,390 |
| 32 | British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults | Gut | 2019 | 1,353 |
| 33 | Cytological detection of mutagen–carcinogen exposure by sister chromatid exchange | Nature | 1975 | 1,335 |
| 34 | Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery | Lancet, The | 2004 | 1,334 |
| 35 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 36 | Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging | Lancet Neurology, The | 2013 | 1,269 |
| 37 | Mouse Small eye results from mutations in a paired-like homeobox-containing gene | Nature | 1991 | 1,260 |
| 38 | Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 1,257 |
| 39 | Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA | Cell | 1992 | 1,253 |
| 40 | Conducting a critical interpretive synthesis of the literature on access to healthcare by vulnerable groups | BMC Medical Research Methodology | 2006 | 1,217 |
| 41 | Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors | Genes Chromosomes and Cancer | 1994 | 1,215 |
| 42 | Genome-wide analysis of mammalian promoter architecture and evolution | Nature Genetics | 2006 | 1,201 |
| 43 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,201 |
| 44 | Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials | Lancet, The | 2010 | 1,168 |
| 45 | Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018 | World Journal of Surgery | 2019 | 1,166 |
| 46 | Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies | Science | 2002 | 1,129 |
| 47 | Guidelines for the management of inflammatory bowel disease in adults | Gut | 2011 | 1,127 |
| 48 | SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis | Lancet Microbe, The | 2021 | 1,111 |
| 49 | Apolipoprotein E genotyping by one-stage PCR | Lancet, The | 1991 | 1,082 |
| 50 | Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility | Nature Genetics | 2007 | 1,063 |
