| # | Title | Journal | Year | Citations |
|---|
| 1 | Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis | Nature | 1998 | 2,565 |
| 2 | Genomic atlas of the human plasma proteome | Nature | 2018 | 1,180 |
| 3 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 4 | Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution | Nature Genetics | 2010 | 836 |
| 5 | Genome-wide association analysis identifies 20 loci that influence adult height | Nature Genetics | 2008 | 742 |
| 6 | hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer | Clinical Cancer Research | 2008 | 617 |
| 7 | Meta-analysis and imputation refines the association of 15q25 with smoking quantity | Nature Genetics | 2010 | 581 |
| 8 | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture | Nature Genetics | 2013 | 578 |
| 9 | Susceptibility to ankylosing spondylitis in twins the role of genes, HLA, and the environment | Arthritis and Rheumatism | 1997 | 561 |
| 10 | QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data | Nucleic Acids Research | 2007 | 525 |
| 11 | Bayesian refinement of association signals for 14 loci in 3 common diseases | Nature Genetics | 2012 | 469 |
| 12 | Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia | Nature Genetics | 2009 | 445 |
| 13 | Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition | Journal of Biological Chemistry | 2006 | 434 |
| 14 | A new chromosome 17q21.31 microdeletion syndrome associated with a common inversion polymorphism | Nature Genetics | 2006 | 418 |
| 15 | Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia | American Journal of Human Genetics | 2008 | 397 |
| 16 | Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits | PLoS Genetics | 2013 | 371 |
| 17 | Melanopsin: an exciting photopigment | Trends in Neurosciences | 2008 | 366 |
| 18 | The immunogenetics of asthma and eczema: a new focus on the epithelium | Nature Reviews Immunology | 2004 | 349 |
| 19 | Regulation of autophagy by ATF4 in response to severe hypoxia | Oncogene | 2010 | 320 |
| 20 | Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension | PLoS Genetics | 2010 | 312 |
| 21 | SLC2A9 Is a High-Capacity Urate Transporter in Humans | PLoS Medicine | 2008 | 305 |
| 22 | Vulnerabilities in coronavirus glycan shields despite extensive glycosylation | Nature Communications | 2020 | 304 |
| 23 | Short-Wavelength Light Sensitivity of Circadian, Pupillary, and Visual Awareness in Humans Lacking an Outer Retina | Current Biology | 2007 | 296 |
| 24 | Structure and functionality in flavivirus NS-proteins: Perspectives for drug design | Antiviral Research | 2010 | 289 |
| 25 | microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast Cancer | Cancer Research | 2011 | 285 |
| 26 | A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2 | Nature Genetics | 2009 | 276 |
| 27 | Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG) | Gut | 2020 | 263 |
| 28 | Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs | Cell Stem Cell | 2012 | 261 |
| 29 | Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk | Nature Genetics | 2010 | 248 |
| 30 | Genome-wide mapping of human loci for essential hypertension | Lancet, The | 2003 | 247 |
| 31 | Genetic loci influencing kidney function and chronic kidney disease | Nature Genetics | 2010 | 246 |
| 32 | Development and tissue origins of the mammalian cranial base | Developmental Biology | 2008 | 244 |
| 33 | The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis | British Journal of Cancer | 2011 | 244 |
| 34 | Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis | Annals of the Rheumatic Diseases | 2000 | 241 |
| 35 | Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation | Nature Structural Biology | 1999 | 235 |
| 36 | Common variants at 19p13 are associated with susceptibility to ovarian cancer | Nature Genetics | 2010 | 235 |
| 37 | Severe Malarial Anemia and Cerebral Malaria Are Associated with Different Tumor Necrosis Factor Promoter Alleles | Journal of Infectious Diseases | 1999 | 231 |
| 38 | Whole-Genome Screening in Ankylosing Spondylitis: Evidence of Non-MHC Genetic-Susceptibility Loci | American Journal of Human Genetics | 2001 | 231 |
| 39 | Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status | Journal of Pathology | 2011 | 225 |
| 40 | hsa‐miR‐210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer | Cancer | 2010 | 215 |
| 41 | Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche | Nature Medicine | 2015 | 213 |
| 42 | Toremifene interacts with and destabilizes the Ebola virus glycoprotein | Nature | 2016 | 210 |
| 43 | The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation | Journal of Experimental Medicine | 2007 | 206 |
| 44 | Clinical utilisation of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation | Journal of Medical Genetics | 2014 | 200 |
| 45 | Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway | Nature Genetics | 2004 | 190 |
| 46 | Genetic Predisposition of the Interleukin-6 Response to Inflammation: Implications for a Variety of Major Diseases? | Clinical Chemistry | 2004 | 185 |
| 47 | Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1 | Blood | 2009 | 183 |
| 48 | Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma | Nature Communications | 2017 | 179 |
| 49 | Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials | Chemical Science | 2017 | 174 |
| 50 | Genomic analysis of local variation and recent evolution in Plasmodium vivax | Nature Genetics | 2016 | 169 |
