| # | Title | Journal | Year | Citations |
|---|
| 1 | Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond | Statistics in Medicine | 2008 | 5,331 |
| 2 | 3D bioprinting of tissues and organs | Nature Biotechnology | 2014 | 5,158 |
| 3 | Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group | | 1998 | 4,697 |
| 4 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery | Journal of the American College of Cardiology | 2002 | 3,941 |
| 5 | Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis | Nature Medicine | 2013 | 3,355 |
| 6 | Rapamycin fed late in life extends lifespan in genetically heterogeneous mice | Nature | 2009 | 3,191 |
| 7 | A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury | Nature Medicine | 2005 | 2,986 |
| 8 | Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2009 | 2,904 |
| 9 | Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America | Clinical Infectious Diseases | 2016 | 2,060 |
| 10 | Osteoarthritis: A disease of the joint as an organ | Arthritis and Rheumatism | 2012 | 2,055 |
| 11 | Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program | American Journal of Respiratory and Critical Care Medicine | 2010 | 1,820 |
| 12 | Isolation of amniotic stem cell lines with potential for therapy | Nature Biotechnology | 2007 | 1,739 |
| 13 | Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans | Science | 2010 | 1,725 |
| 14 | Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions | American Journal of Transplantation | 2008 | 1,710 |
| 15 | Tissue-engineered autologous bladders for patients needing cystoplasty | Lancet, The | 2006 | 1,690 |
| 16 | Matrix metalloproteinases as modulators of inflammation and innate immunity | Nature Reviews Immunology | 2004 | 1,655 |
| 17 | Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress | Molecular and Cellular Biology | 2006 | 1,627 |
| 18 | Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation | Nature Medicine | 2003 | 1,606 |
| 19 | Angiotensin-converting enzyme 2 is an essential regulator of heart function | Nature | 2002 | 1,586 |
| 20 | Curcumin: From ancient medicine to current clinical trials | Cellular and Molecular Life Sciences | 2008 | 1,549 |
| 21 | A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study | Gynecologic Oncology | 2004 | 1,531 |
| 22 | Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05 | International Journal of Radiation Oncology Biology Physics | 2000 | 1,436 |
| 23 | Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2 | Circulation | 2005 | 1,390 |
| 24 | Guidelines for the Management of Intravascular Catheter-Related Infections | Clinical Infectious Diseases | 2001 | 1,354 |
| 25 | Inflammation in prostate carcinogenesis | Nature Reviews Cancer | 2007 | 1,352 |
| 26 | Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight and Obese Individuals With Type 2 Diabetes | Diabetes Care | 2011 | 1,342 |
| 27 | ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease | American Journal of Gastroenterology | 2013 | 1,341 |
| 28 | Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps | Nature Genetics | 2018 | 1,331 |
| 29 | Psoriasis causes as much disability as other major medical diseases | Journal of the American Academy of Dermatology | 1999 | 1,325 |
| 30 | Comments on ‘Integrated discrimination and net reclassification improvements—Practical advice’ | Statistics in Medicine | 2008 | 1,299 |
| 31 | Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the US Population, 2012 | JAMA Dermatology | 2015 | 1,290 |
| 32 | Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death | JAMA - Journal of the American Medical Association | 2004 | 1,200 |
| 33 | Effects of Estrogen Replacement on the Progression of Coronary-Artery Atherosclerosis | New England Journal of Medicine | 2000 | 1,186 |
| 34 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial | Lancet, The | 2010 | 1,182 |
| 35 | Multisensory integration: current issues from the perspective of the single neuron | Nature Reviews Neuroscience | 2008 | 1,180 |
| 36 | Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009 | JAMA - Journal of the American Medical Association | 2014 | 1,160 |
| 37 | Conjugated Equine Estrogens and Incidence of Probable Dementia and Mild Cognitive Impairment in Postmenopausal WomenWomen's Health Initiative Memory Study | JAMA - Journal of the American Medical Association | 2004 | 1,149 |
| 38 | Guidelines of care for the management of psoriasis and psoriatic arthritis | Journal of the American Academy of Dermatology | 2008 | 1,128 |
| 39 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,124 |
| 40 | Early intensive care unit mobility therapy in the treatment of acute respiratory failure* | Critical Care Medicine | 2008 | 1,101 |
| 41 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture | Nature Genetics | 2012 | 1,100 |
| 42 | The Salmeterol Multicenter Asthma Research Trial | Chest | 2006 | 1,091 |
| 43 | Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program | Nature | 2021 | 1,069 |
| 44 | Prospective Evaluation of a Method for Estimating Ascending Aortic Pressure From the Radial Artery Pressure Waveform | Hypertension | 2001 | 1,056 |
| 45 | Trust in Physicians and Medical Institutions: What Is It, Can It Be Measured, and Does It Matter? | Milbank Quarterly | 2001 | 1,043 |
| 46 | The Influence of CCL3L1 Gene-Containing Segmental Duplications on HIV-1/AIDS Susceptibility | Science | 2005 | 1,040 |
| 47 | Intensive glucose control and macrovascular outcomes in type 2 diabetes | Diabetologia | 2009 | 1,033 |
| 48 | A pragmatic–explanatory continuum indicator summary (PRECIS): a tool to help trial designers | Journal of Clinical Epidemiology | 2009 | 1,013 |
| 49 | Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years | JAMA - Journal of the American Medical Association | 2016 | 991 |
| 50 | Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study | American Journal of Clinical Nutrition | 2008 | 978 |
