| # | Title | Journal | Year | Citations |
|---|
| 1 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial | Lancet, The | 2010 | 1,182 |
| 2 | Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums | Nature Reviews Neurology | 2018 | 905 |
| 3 | Using Local Microbiologic Data To Develop Institution-Specific Guidelines for the Treatment of Hospital-Acquired Pneumonia | Chest | 2006 | 669 |
| 4 | Human hepatic stem cells from fetal and postnatal donors | Journal of Experimental Medicine | 2007 | 551 |
| 5 | The epidemiology of lung cancer | Translational Lung Cancer Research | 2018 | 488 |
| 6 | HIV and Aging | Journal of Acquired Immune Deficiency Syndromes (1999) | 2012 | 474 |
| 7 | Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy | Lancet Neurology, The | 2011 | 455 |
| 8 | Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017 | JAMA - Journal of the American Medical Association | 2020 | 419 |
| 9 | Aspiration thrombectomy versus stent retriever thrombectomy as first-line approach for large vessel occlusion (COMPASS): a multicentre, randomised, open label, blinded outcome, non-inferiority trial | Lancet, The | 2019 | 365 |
| 10 | Chronic Pruritus | New England Journal of Medicine | 2013 | 348 |
| 11 | Pseudomyxoma Peritonei of Appendiceal Origin: A Clinicopathologic Analysis of 101 Patients Uniformly Treated at a Single Institution, With Literature Review | American Journal of Surgical Pathology | 2006 | 325 |
| 12 | Predictors of Successful Extubation in Neurosurgical Patients | American Journal of Respiratory and Critical Care Medicine | 2001 | 324 |
| 13 | Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas | Oncogene | 2013 | 324 |
| 14 | Education of Physicians-in-Training Can Decrease the Risk for Vascular Catheter Infection | Annals of Internal Medicine | 2000 | 314 |
| 15 | Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 308 |
| 16 | Comparison of gastric emptying of a nondigestible capsule to a radio‐labelled meal in healthy and gastroparetic subjects | Alimentary Pharmacology and Therapeutics | 2008 | 293 |
| 17 | Visceral Adiposity and the Risk of Metabolic Syndrome Across Body Mass Index | JACC: Cardiovascular Imaging | 2014 | 291 |
| 18 | Multivariate Analysis of Risk Factors for Death Following Gastric Bypass for Treatment of Morbid Obesity | Annals of Surgery | 2004 | 282 |
| 19 | Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study | Lancet Oncology, The | 2019 | 279 |
| 20 | Pediatric Severe Sepsis in U.S. Children’s Hospitals* | Pediatric Critical Care Medicine | 2014 | 270 |
| 21 | Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy With Mitomycin C for Peritoneal Carcinomatosis from Nonappendiceal Colorectal Carcinoma | Annals of Surgical Oncology | 2004 | 267 |
| 22 | Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders | Journal of Allergy and Clinical Immunology | 2017 | 261 |
| 23 | Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP) | Journal of Hypertension | 2000 | 258 |
| 24 | Receiving Early Mobility During an Intensive Care Unit Admission Is a Predictor of Improved Outcomes in Acute Respiratory Failure | American Journal of the Medical Sciences | 2011 | 244 |
| 25 | Analysis of Intracorporeal Compared with Extracorporeal Urinary Diversion After Robot-assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium | European Urology | 2014 | 242 |
| 26 | Evidence‐ and consensus‐based (S3) Guidelines for the Treatment of Actinic Keratosis – International League of Dermatological Societies in cooperation with the European Dermatology Forum – Short version | Journal of the European Academy of Dermatology and Venereology | 2015 | 234 |
| 27 | Phase I Trial of Twice-Weekly Gemcitabine and Concurrent Radiation in Patients With Advanced Pancreatic Cancer | Journal of Clinical Oncology | 1999 | 226 |
| 28 | Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci | Nature Genetics | 2016 | 223 |
| 29 | High-Resolution Fluorodeoxyglucose Positron Emission Tomography with Compression ("Positron Emission Mammography") is Highly Accurate in Depicting Primary Breast Cancer | Breast Journal | 2006 | 218 |
| 30 | Diagnosis and Subclassification of Primary and Recurrent Lymphoma | American Journal of Clinical Pathology | 2000 | 217 |
| 31 | Design and Baseline Characteristics for the Aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II) | Contemporary Clinical Trials | 1999 | 213 |
| 32 | Randomized Comparison of Everolimus- and Paclitaxel-Eluting Stents | Journal of the American College of Cardiology | 2011 | 213 |
| 33 | Do Stool Form and Frequency Correlate With Whole-Gut and Colonic Transit? Results From a Multicenter Study in Constipated Individuals and Healthy Controls | American Journal of Gastroenterology | 2010 | 202 |
| 34 | Tumor mutational burden is a determinant of immune-mediated survival in breast cancer | OncoImmunology | 2018 | 200 |
| 35 | MR Imaging of Maternal Diseases of the Abdomen and Pelvis during Pregnancy and the Immediate Postpartum Period | Radiographics | 2004 | 199 |
| 36 | Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA®) | Diabetes and Vascular Disease Research | 2015 | 197 |
| 37 | Efficacy and Safety of Ibuprofen and Acetaminophen in Children and Adults: A Meta-Analysis and Qualitative Review | Annals of Pharmacotherapy | 2010 | 192 |
| 38 | The relation of obesity throughout life to carotid intima-media thickness in adulthood: the Bogalusa Heart Study | International Journal of Obesity | 2004 | 190 |
| 39 | Association of MUC16 Mutation With Tumor Mutation Load and Outcomes in Patients With Gastric Cancer | JAMA Oncology | 2018 | 190 |
| 40 | Functional Voice Disorders | Otolaryngologic Clinics of North America | 1991 | 186 |
| 41 | Factors Predicting Survival After Intraperitoneal Hyperthermic Chemotherapy With Mitomycin C After Cytoreductive Surgery for Patients With Peritoneal Carcinomatosis | Archives of Surgery | 2003 | 185 |
| 42 | Residual and Recurrent Disease Following Renal Energy Ablative Therapy: A Multi-Institutional Study | Journal of Urology | 2006 | 185 |
| 43 | Frequent Hemodialysis Network (FHN) randomized trials: Study design | Kidney International | 2007 | 176 |
| 44 | The Effects of Altered Apolipoprotein A-I Structure on Plasma HDL Concentration | Trends in Cardiovascular Medicine | 2002 | 172 |
| 45 | Accuracy and clinical relevance of computed tomography scan interpretation of peritoneal cancer index in colorectal cancer peritoneal carcinomatosis: A multi‐institutional study | Journal of Surgical Oncology | 2010 | 164 |
| 46 | Consensus Guidelines from The American Society of Peritoneal Surface Malignancies on Standardizing the Delivery of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Patients in the United States | Annals of Surgical Oncology | 2014 | 161 |
| 47 | The contribution of childhood obesity to adult carotid intima-media thickness: the Bogalusa Heart Study | International Journal of Obesity | 2008 | 159 |
| 48 | Reflux of gastric juice and glue ear in children | Lancet, The | 2002 | 154 |
| 49 | Sepsis and Septic Shock – Basics of diagnosis, pathophysiology and clinical decision making | Medical Clinics of North America | 2020 | 153 |
| 50 | Evidence-Based Review of the Literature on Intrathecal Delivery of Pain Medication | Journal of Pain and Symptom Management | 2000 | 151 |
