| # | Title | Journal | Year | Citations |
|---|
| 1 | Animal models of human disease: zebrafish swim into view | Nature Reviews Genetics | 2007 | 1,829 |
| 2 | Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins | Cell | 2012 | 1,765 |
| 3 | Neuregulin 1 and Susceptibility to Schizophrenia | American Journal of Human Genetics | 2002 | 1,550 |
| 4 | Transglutaminases: crosslinking enzymes with pleiotropic functions | Nature Reviews Molecular Cell Biology | 2003 | 1,308 |
| 5 | Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program | Nature | 2021 | 1,069 |
| 6 | Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA | Nucleic Acids Research | 2012 | 793 |
| 7 | Clinical Relevance of Biomarkers of Oxidative Stress | Antioxidants and Redox Signaling | 2015 | 604 |
| 8 | The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation | Atherosclerosis | 2015 | 587 |
| 9 | hERG K+Channels: Structure, Function, and Clinical Significance | Physiological Reviews | 2012 | 581 |
| 10 | Multi-ethnic genome-wide association study for atrial fibrillation | Nature Genetics | 2018 | 552 |
| 11 | Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7 | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 541 |
| 12 | ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation | Nature Cell Biology | 2015 | 541 |
| 13 | The Role of Hypoxia in Development of the Mammalian Embryo | Developmental Cell | 2009 | 509 |
| 14 | An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation | Cell | 2007 | 470 |
| 15 | Chamber Formation and Morphogenesis in the Developing Mammalian Heart | Developmental Biology | 2000 | 447 |
| 16 | Germline epimutation of MLH1 in individuals with multiple cancers | Nature Genetics | 2004 | 443 |
| 17 | CIDR: Ultrafast and accurate clustering through imputation for single-cell RNA-seq data | Genome Biology | 2017 | 440 |
| 18 | Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise | Cell Metabolism | 2018 | 426 |
| 19 | Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway | Nature | 1999 | 418 |
| 20 | The RNA-binding protein repertoire of embryonic stem cells | Nature Structural and Molecular Biology | 2013 | 415 |
| 21 | Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension | Nature Communications | 2016 | 391 |
| 22 | From The Cover: Germ-line epigenetic modification of the murine Avy allele by nutritional supplementation | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 382 |
| 23 | Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury | ELife | 2019 | 379 |
| 24 | Piezo1 Channels Are Inherently Mechanosensitive | Cell Reports | 2016 | 366 |
| 25 | α 1 -Adrenergic Receptor Subtypes | Circulation Research | 1996 | 365 |
| 26 | Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin | Cell Stem Cell | 2011 | 358 |
| 27 | Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: a case series | Lancet, The | 2015 | 345 |
| 28 | Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env | Nature Structural and Molecular Biology | 2015 | 333 |
| 29 | Retrotransposons as epigenetic mediators of phenotypic variation in mammals | Nature Genetics | 2001 | 327 |
| 30 | Cardiac Septal and Valvular Dysmorphogenesis in Mice Heterozygous for Mutations in the Homeobox Gene Nkx2-5 | Circulation Research | 2000 | 325 |
| 31 | Mutations in Cardiac T-Box Factor Gene TBX20 Are Associated with Diverse Cardiac Pathologies, Including Defects of Septation and Valvulogenesis and Cardiomyopathy | American Journal of Human Genetics | 2007 | 317 |
| 32 | Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells | Molecular Cell | 2016 | 317 |
| 33 | Epidemiology and treatment of pulmonary arterial hypertension | Nature Reviews Cardiology | 2017 | 310 |
| 34 | SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation | Nature Genetics | 2008 | 305 |
| 35 | Molecular Mechanisms of Inherited Cardiomyopathies | Physiological Reviews | 2002 | 286 |
| 36 | Nuclear compartmentalization and gene activity | Nature Reviews Molecular Cell Biology | 2000 | 276 |
| 37 | Targeted Inactivation of Gh/Tissue Transglutaminase II | Journal of Biological Chemistry | 2001 | 263 |
| 38 | Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study | Journal of Cardiovascular Magnetic Resonance | 2014 | 262 |
| 39 | National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Guidelines for the Prevention, Detection, and Management of Heart Failure in Australia 2018 | Heart Lung and Circulation | 2018 | 262 |
| 40 | Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus | Genes and Development | 2000 | 261 |
| 41 | Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart | Developmental Biology | 2003 | 260 |
| 42 | A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm | Journal of Biomolecular Screening | 2016 | 259 |
| 43 | Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development | Cell | 2002 | 256 |
| 44 | Cardiac Regenerative Capacity and Mechanisms | Annual Review of Cell and Developmental Biology | 2012 | 254 |
| 45 | Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding | Science | 2011 | 251 |
| 46 | Increased nitric oxide production in heart failure | Lancet, The | 1994 | 250 |
| 47 | Neuregulin-1/erbB-Activation Improves Cardiac Function and Survival in Models of Ischemic, Dilated, and Viral Cardiomyopathy | Journal of the American College of Cardiology | 2006 | 241 |
| 48 | Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug | Nature Biotechnology | 2009 | 241 |
| 49 | A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number | Cell | 2014 | 233 |
| 50 | Cardiac homeobox gene NKX2-5mutations and congenital heart disease | Journal of the American College of Cardiology | 2003 | 231 |
