| # | Title | Journal | Year | Citations |
|---|
| 1 | New diagnostic criteria for multiple sclerosis: Guidelines for research protocols | Annals of Neurology | 1983 | 7,193 |
| 2 | Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer | Science | 1989 | 6,473 |
| 3 | Comprehensive genomic profiles of small cell lung cancer | Nature | 2015 | 1,634 |
| 4 | Risk of cardiovascular mortality in patients with rheumatoid arthritis: A meta‐analysis of observational studies | Arthritis and Rheumatism | 2008 | 1,181 |
| 5 | Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial | Lancet, The | 2016 | 1,070 |
| 6 | Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial | Lancet, The | 2016 | 1,050 |
| 7 | Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study | Lancet Oncology, The | 2011 | 1,028 |
| 8 | Probability of Cancer in Pulmonary Nodules Detected on First Screening CT | New England Journal of Medicine | 2013 | 1,020 |
| 9 | Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration | Acta Neuropathologica | 2007 | 978 |
| 10 | A Prospective Study of Sleep Duration and Coronary Heart Disease in Women | Archives of Internal Medicine | 2003 | 957 |
| 11 | Complications of endotracheal intubation in the critically ill | Intensive Care Medicine | 2008 | 877 |
| 12 | Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update | Acta Neuropathologica | 2010 | 854 |
| 13 | TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia | Lancet Neurology, The | 2010 | 816 |
| 14 | ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import | EMBO Journal | 2010 | 717 |
| 15 | Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomised, open-label, phase 3 trial | Lancet Oncology, The | 2013 | 710 |
| 16 | Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients With Coronavirus Disease 2019 (COVID-19) | Clinical Infectious Diseases | 2020 | 708 |
| 17 | Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids | Nature Medicine | 2015 | 591 |
| 18 | A Prospective Study of Sleep Duration and Mortality Risk in Women | Sleep | 2004 | 568 |
| 19 | Traumatic Spinal Cord Injury—Repair and Regeneration | Neurosurgery | 2017 | 554 |
| 20 | Independent Impact of Gout on Mortality and Risk for Coronary Heart Disease | Circulation | 2007 | 546 |
| 21 | A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia | Blood | 2013 | 546 |
| 22 | Hereditary Diffuse Gastric Cancer Syndrome | JAMA Oncology | 2015 | 540 |
| 23 | The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030 | Lancet, The | 2021 | 530 |
| 24 | Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion–diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study | Lancet Neurology, The | 2009 | 526 |
| 25 | Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study | Lancet Oncology, The | 2013 | 522 |
| 26 | A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome | Critical Care | 2017 | 515 |
| 27 | Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With RecurrentClostridium difficileInfection | JAMA - Journal of the American Medical Association | 2016 | 511 |
| 28 | Prevalence of the Metabolic Syndrome in Individuals with Hyperuricemia | American Journal of Medicine | 2007 | 505 |
| 29 | Epidemiology and Reporting Characteristics of Systematic Reviews of Biomedical Research: A Cross-Sectional Study | PLoS Medicine | 2016 | 497 |
| 30 | Dual Regulation of NMDA Receptor Functions by Direct Protein-Protein Interactions with the Dopamine D1 Receptor | Cell | 2002 | 492 |
| 31 | Antielastin autoimmunity in tobacco smoking–induced emphysema | Nature Medicine | 2007 | 487 |
| 32 | Nanooncology: The future of cancer diagnosis and therapy | Ca-A Cancer Journal for Clinicians | 2013 | 481 |
| 33 | Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions | Nature Genetics | 2010 | 479 |
| 34 | Accidental Hypothermia | New England Journal of Medicine | 2012 | 475 |
| 35 | Real-time differentiation of adenomatous and hyperplastic diminutive colorectal polyps during analysis of unaltered videos of standard colonoscopy using a deep learning model | Gut | 2019 | 462 |
| 36 | Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant | Blood | 2012 | 447 |
| 37 | TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions | American Journal of Pathology | 2007 | 446 |
| 38 | Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study | BMJ: British Medical Journal | 2008 | 443 |
| 39 | Mullerian adenosarcoma of the uterus: A clinicopathologic analysis of 100 cases with a review of the literature | Human Pathology | 1990 | 442 |
| 40 | Assessment of left atrial appendage function by transesophageal echocardiography. Implications for the development of thrombus. | Circulation | 1991 | 437 |
| 41 | Active Surveillance of Small Renal Masses: Progression Patterns of Early Stage Kidney Cancer | European Urology | 2011 | 422 |
| 42 | A multicenter, prospective, randomized, controlled trial of open reduction—internal fixation versus total elbow arthroplasty for displaced intra-articular distal humeral fractures in elderly patients | Journal of Shoulder and Elbow Surgery | 2009 | 416 |
| 43 | Spontaneous Coronary Artery Dissection | Journal of the American College of Cardiology | 2017 | 416 |
| 44 | Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology | Multiple Sclerosis Journal | 2006 | 414 |
| 45 | Contemporary Review on Spontaneous Coronary Artery Dissection | Journal of the American College of Cardiology | 2016 | 412 |
| 46 | Chronic Hypersensitivity Pneumonitis: Differentiation from Idiopathic Pulmonary Fibrosis and Nonspecific Interstitial Pneumonia by Using Thin-Section CT | Radiology | 2008 | 405 |
| 47 | Propofol vs Midazolam for ICU Sedation | Chest | 2001 | 402 |
| 48 | Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial | Lancet Infectious Diseases, The | 2016 | 402 |
| 49 | Tumors metastatic to the orbit: A changing picture | Survey of Ophthalmology | 1990 | 396 |
| 50 | IX. Dr. John Albertson Sampson | International Journal of Gynecological Pathology | 2001 | 393 |
