| # | Title | Journal | Year | Citations |
|---|
| 1 | Diagnosis, management, and treatment of hepatitis C: An update | Hepatology | 2009 | 2,610 |
| 2 | Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica | Science | 2008 | 2,289 |
| 3 | Hypertension in mice lacking the gene for endothelial nitric oxide synthase | Nature | 1995 | 1,932 |
| 4 | Influence of diet on the gut microbiome and implications for human health | Journal of Translational Medicine | 2017 | 1,714 |
| 5 | Simplified criteria for the diagnosis of autoimmune hepatitis | Hepatology | 2008 | 1,553 |
| 6 | ESPEN guidelines on definitions and terminology of clinical nutrition | Clinical Nutrition | 2017 | 1,451 |
| 7 | Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1 | Nature Genetics | 1994 | 1,416 |
| 8 | Dexmedetomidine vs Midazolam for Sedation of Critically Ill Patients<subtitle>A Randomized Trial</subtitle> | JAMA - Journal of the American Medical Association | 2009 | 1,409 |
| 9 | GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community | Clinical Nutrition | 2019 | 1,395 |
| 10 | Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome) | Clinical Nutrition | 2000 | 1,391 |
| 11 | Germline Mutations in the Extracellular Domains of the 55 kDa TNF Receptor, TNFR1, Define a Family of Dominantly Inherited Autoinflammatory Syndromes | Cell | 1999 | 1,271 |
| 12 | Diagnosis and management of autoimmune hepatitis | Hepatology | 2010 | 1,243 |
| 13 | PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS | Annals of the New York Academy of Sciences | 1965 | 1,222 |
| 14 | HGVS Recommendations for the Description of Sequence Variants: 2016 Update | Human Mutation | 2016 | 1,194 |
| 15 | Management of Spontaneous Pneumothorax | Chest | 2001 | 1,119 |
| 16 | Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome | Lancet, The | 2005 | 1,048 |
| 17 | BrafV600E cooperates with Pten loss to induce metastatic melanoma | Nature Genetics | 2009 | 1,022 |
| 18 | Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study | Diabetes | 2002 | 992 |
| 19 | Hereditary Hemorrhagic Telangiectasia | New England Journal of Medicine | 1995 | 986 |
| 20 | An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases | Hepatology | 2011 | 961 |
| 21 | A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance | Developmental Cell | 2009 | 865 |
| 22 | Mechanisms in the Pathogenesis of Asbestosis and Silicosis | American Journal of Respiratory and Critical Care Medicine | 1998 | 827 |
| 23 | Contrast Medium-Induced Acute Kidney Injury | CardioRenal Medicine | 2015 | 791 |
| 24 | Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test results | Human Mutation | 2008 | 782 |
| 25 | Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction | American Journal of Obstetrics and Gynecology | 2000 | 736 |
| 26 | The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases | Cell | 1995 | 702 |
| 27 | Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor | Nature | 2011 | 695 |
| 28 | Ventilation of patients with acute lung injury and acute respiratory distress syndrome: Has new evidence changed clinical practice?* | Critical Care Medicine | 2004 | 691 |
| 29 | Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome 1 ☆ | Gastroenterology | 2004 | 684 |
| 30 | Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam | Science | 1982 | 682 |
| 31 | Redox-based regulation of signal transduction: Principles, pitfalls, and promises | Free Radical Biology and Medicine | 2008 | 681 |
| 32 | Cardiac Rehabilitation and Secondary Prevention of Coronary Heart Disease | New England Journal of Medicine | 2001 | 671 |
| 33 | Cytokines of the Lung | The American Review of Respiratory Disease | 1990 | 650 |
| 34 | GLIM Criteria for the Diagnosis of Malnutrition: A Consensus Report From the Global Clinical Nutrition Community | Journal of Parenteral and Enteral Nutrition | 2019 | 644 |
| 35 | Randomized, comparative study of interferon β-1a treatment regimens in MS | Neurology | 2002 | 636 |
| 36 | The relation of body fat mass and distribution to markers of chronic inflammation | International Journal of Obesity | 2001 | 575 |
| 37 | Longitudinal changes in insulin release and insulin resistance in nonobese pregnant women | American Journal of Obstetrics and Gynecology | 1991 | 574 |
| 38 | Epidemiology and Risk Factors for Venous Thrombosis | Seminars in Hematology | 2007 | 572 |
| 39 | Early and Late Repair of Lateral Ligament of the Ankle | Foot & Ankle | 1980 | 571 |
| 40 | Differential diagnosis of suspected multiple sclerosis: a consensus approach | Multiple Sclerosis Journal | 2008 | 560 |
| 41 | Altered myocardial force-frequency relation in human heart failure. | Circulation | 1992 | 558 |
| 42 | Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years | JAMA Pediatrics | 2018 | 551 |
| 43 | Hypokalemia | New England Journal of Medicine | 1998 | 543 |
| 44 | The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways | Current Biology | 2000 | 536 |
| 45 | Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial | Lancet, The | 2010 | 534 |
| 46 | The transcriptional landscape of age in human peripheral blood | Nature Communications | 2015 | 533 |
| 47 | The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly: The Cardiovascular Health Study | Diabetes | 2001 | 530 |
| 48 | GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community | Journal of Cachexia, Sarcopenia and Muscle | 2019 | 514 |
| 49 | Anastomotic Leaks After Intestinal Anastomosis | Annals of Surgery | 2007 | 513 |
| 50 | What is all that thrombin for? | Journal of Thrombosis and Haemostasis | 2003 | 480 |
