| # | Title | Journal | Year | Citations |
|---|
| 1 | Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability | Science | 1995 | 2,173 |
| 2 | Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea | Carcinogenesis | 1989 | 1,543 |
| 3 | Sir Isaac Newton, sepsis, SIRS, and CARS | Critical Care Medicine | 1996 | 1,007 |
| 4 | Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications | Cancer | 1994 | 851 |
| 5 | Clinical Practice Guideline: Tonsillectomy in Children | Otolaryngology - Head and Neck Surgery | 2011 | 788 |
| 6 | Many paths to methyltransfer: a chronicle of convergence | Trends in Biochemical Sciences | 2003 | 766 |
| 7 | Why drinking green tea could prevent cancer | Nature | 1997 | 656 |
| 8 | Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action | Critical Reviews in Food Science and Nutrition | 2004 | 634 |
| 9 | Effect of blood transfusion on long-term survival after cardiac operation | Annals of Thoracic Surgery | 2002 | 626 |
| 10 | Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome | Critical Care Medicine | 1996 | 603 |
| 11 | Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy | Advanced Drug Delivery Reviews | 2004 | 569 |
| 12 | Cardiovascular Risk Factors Emerge After Artificial Selection for Low Aerobic Capacity | Science | 2005 | 559 |
| 13 | Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor | Science | 1982 | 507 |
| 14 | Effect of transradial access on quality of life and cost of cardiac catheterization: A randomized comparison | American Heart Journal | 1999 | 507 |
| 15 | Clinical Practice Guideline: Bell's Palsy | Otolaryngology - Head and Neck Surgery | 2013 | 493 |
| 16 | Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation | Nature Genetics | 1996 | 474 |
| 17 | Inhibition of aldosterone production by an atrial extract | Science | 1984 | 463 |
| 18 | Urease as a Virulence Factor in Experimental Cryptococcosis | Infection and Immunity | 2000 | 459 |
| 19 | ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK) | Oncogene | 1997 | 455 |
| 20 | A new approach to the oral administration of insulin and other peptide drugs | Science | 1986 | 450 |
| 21 | Elevated interleukin‐6 and severe COVID‐19: A meta‐analysis | Journal of Medical Virology | 2020 | 436 |
| 22 | Metabolic Response to Injury and Illness: Estimation of Energy and Protein Needs from Indirect Calorimetry and Nitrogen Balance | Journal of Parenteral and Enteral Nutrition | 1979 | 424 |
| 23 | Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis | Lung Cancer | 2001 | 407 |
| 24 | Oxytocin receptors: triggers for parturition and lactation? | Science | 1979 | 395 |
| 25 | Mouse liver cell culture | In Vitro | 1981 | 377 |
| 26 | Genetic Analysis of Inherited Hypertension in the Rat | Physiological Reviews | 2000 | 375 |
| 27 | A practical approach to the echocardiographic evaluation of diastolic function | Journal of the American Society of Echocardiography | 2004 | 371 |
| 28 | Glucose repression in the yeast Saccharomyces cerevisiae | Molecular Microbiology | 1992 | 366 |
| 29 | XENOGENEIC EXTRACELLULAR MATRIX GRAFTS ELICIT A TH2-RESTRICTED IMMUNE RESPONSE1 | Transplantation | 2001 | 342 |
| 30 | Regulation of Cell Migration by the Calcium-dependent Protease Calpain | Journal of Biological Chemistry | 1997 | 338 |
| 31 | Environmental Risk Factors and Parkinson's Disease: A Metaanalysis | Environmental Research | 2001 | 338 |
| 32 | DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis | Carcinogenesis | 1999 | 334 |
| 33 | Ouabain Interaction with Cardiac Na+/K+-ATPase Initiates Signal Cascades Independent of Changes in Intracellular Na+ and Ca2+ Concentrations | Journal of Biological Chemistry | 2000 | 323 |
| 34 | Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex | Science | 1992 | 316 |
| 35 | Artificial selection for intrinsic aerobic endurance running capacity in rats | Physiological Genomics | 2001 | 315 |
| 36 | Classification of Proliferative Pulmonary Lesions of the Mouse | Cancer Research | 2004 | 313 |
| 37 | The Radiologic Diagnosis of Autopsyproven Ventilator-associated Pneumonia | Chest | 1992 | 312 |
| 38 | A Study of the Clinical Test of Sensory Interaction and Balance | Physical Therapy | 1993 | 311 |
| 39 | The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension | Journal of Neurology | 2017 | 311 |
| 40 | Calcium‐dependent proteases: an enzyme system active at cellular membranes? | FASEB Journal | 1987 | 310 |
| 41 | Coronavirus transcription: subgenomic mouse hepatitis virus replicative intermediates function in RNA synthesis | Journal of Virology | 1990 | 299 |
| 42 | A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease | Journal of Neuroinflammation | 2012 | 293 |
| 43 | Purification and characterization of the catalytic subunit of adenosine 3':5'-cyclic monophosphate-dependent protein kinase from bovine liver | Biochemical Journal | 1976 | 291 |
| 44 | Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells | Journal of Biological Chemistry | 1995 | 290 |
| 45 | A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure | Science | 1989 | 286 |
| 46 | Intracellular Reactive Oxygen Species Mediate the Linkage of Na+/K+-ATPase to Hypertrophy and Its Marker Genes in Cardiac Myocytes | Journal of Biological Chemistry | 1999 | 281 |
| 47 | Paget's disease of the vulva: Prevalence of associated vulvar adenocarcinoma, invasive Paget's disease, and recurrence after surgical excision | American Journal of Obstetrics and Gynecology | 1999 | 273 |
| 48 | Nitric oxide synthase immunoreactivity in the rat, mouse, cat and squirrel monkey spinal cord | Neuroscience | 1993 | 270 |
| 49 | A Nonsimultaneous, Extended, Altruistic-Donor Chain | New England Journal of Medicine | 2009 | 264 |
| 50 | Genotypic identification and characterization of species and strains within the genus Candida by using random amplified polymorphic DNA | Journal of Clinical Microbiology | 1992 | 256 |
