| # | Title | Journal | Year | Citations |
|---|
| 1 | The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis | Arthritis and Rheumatism | 1988 | 18,339 |
| 2 | ESTIMATION OF AVERAGE HETEROZYGOSITY AND GENETIC DISTANCE FROM A SMALL NUMBER OF INDIVIDUALS | Genetics | 1978 | 9,389 |
| 3 | Analysis of Gene Diversity in Subdivided Populations | Proceedings of the National Academy of Sciences of the United States of America | 1973 | 7,553 |
| 4 | The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels | New England Journal of Medicine | 1996 | 7,059 |
| 5 | Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis | Annals of Neurology | 2001 | 6,122 |
| 6 | Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia | New England Journal of Medicine | 2001 | 4,825 |
| 7 | The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents | Pediatrics | 2004 | 4,715 |
| 8 | Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. | Molecular Biology and Evolution | 1986 | 4,402 |
| 9 | Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma | New England Journal of Medicine | 2017 | 3,865 |
| 10 | Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis | New England Journal of Medicine | 2000 | 3,651 |
| 11 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 12 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 13 | Survival in Patients with Primary Pulmonary Hypertension | Annals of Internal Medicine | 1991 | 3,050 |
| 14 | Sequence Variations inPCSK9,Low LDL, and Protection against Coronary Heart Disease | New England Journal of Medicine | 2006 | 2,787 |
| 15 | Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2009 | 2,644 |
| 16 | Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome | New England Journal of Medicine | 2001 | 2,593 |
| 17 | COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up | Journal of the American College of Cardiology | 2020 | 2,392 |
| 18 | Defining the clinical course of multiple sclerosis | Neurology | 2014 | 2,344 |
| 19 | Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network | Pediatrics | 2010 | 2,252 |
| 20 | How We Design Feasibility Studies | American Journal of Preventive Medicine | 2009 | 2,233 |
| 21 | CD4+ Count–Guided Interruption of Antiretroviral Treatment | New England Journal of Medicine | 2006 | 2,099 |
| 22 | Psychiatric Aspects of Impulsivity | American Journal of Psychiatry | 2001 | 2,060 |
| 23 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 24 | THE BOTTLENECK EFFECT AND GENETIC VARIABILITY IN POPULATIONS | Evolution; International Journal of Organic Evolution | 1975 | 2,013 |
| 25 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 26 | Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas | Science | 1989 | 1,945 |
| 27 | Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study | Lancet, The | 2012 | 1,937 |
| 28 | Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part I | Arthritis and Rheumatism | 2008 | 1,918 |
| 29 | Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection | Nature | 1988 | 1,912 |
| 30 | Screening for Prostate Cancer: U.S. Preventive Services Task Force Recommendation Statement | Annals of Internal Medicine | 2012 | 1,872 |
| 31 | Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response | Nature Medicine | 2006 | 1,865 |
| 32 | Specific reading disability (dyslexia): what have we learned in the past four decades? | Journal of Child Psychology and Psychiatry and Allied Disciplines | 2004 | 1,858 |
| 33 | Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery | Nature Reviews Drug Discovery | 2005 | 1,853 |
| 34 | Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells | Circulation | 2000 | 1,711 |
| 35 | 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2013 | 1,705 |
| 36 | Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct | Science | 1996 | 1,696 |
| 37 | Replicating genotype–phenotype associations | Nature | 2007 | 1,509 |
| 38 | Blood Pressure and End-Stage Renal Disease in Men | New England Journal of Medicine | 1996 | 1,502 |
| 39 | Potential Effects of Coronaviruses on the Cardiovascular System | JAMA Cardiology | 2020 | 1,469 |
| 40 | Redox Regulation of Cell Survival | Antioxidants and Redox Signaling | 2008 | 1,464 |
| 41 | Lack of Effect of Induction of Hypothermia after Acute Brain Injury | New England Journal of Medicine | 2001 | 1,462 |
| 42 | Confirmatory factor analysis with ordinal data: Comparing robust maximum likelihood and diagonally weighted least squares | Behavior Research Methods | 2016 | 1,441 |
| 43 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 44 | Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus | Nature Genetics | 2000 | 1,403 |
| 45 | Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia | Blood | 2006 | 1,395 |
| 46 | Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays | Cell Stem Cell | 2008 | 1,392 |
| 47 | Spike mutation D614G alters SARS-CoV-2 fitness | Nature | 2021 | 1,380 |
| 48 | Low Diagnostic Yield of Elective Coronary Angiography | New England Journal of Medicine | 2010 | 1,326 |
| 49 | Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis | New England Journal of Medicine | 2017 | 1,322 |
| 50 | Screening for Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement | Annals of Internal Medicine | 2008 | 1,281 |
