| # | Title | Journal | Year | Citations |
|---|
| 1 | Analysis of protein-coding genetic variation in 60,706 humans | Nature | 2016 | 9,051 |
| 2 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 3 | Burden of valvular heart diseases: a population-based study | Lancet, The | 2006 | 3,825 |
| 4 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,741 |
| 5 | Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes | New England Journal of Medicine | 2014 | 3,474 |
| 6 | The 2015 World Health Organization Classification of Lung Tumors | Journal of Thoracic Oncology | 2015 | 3,313 |
| 7 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 8 | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics | 2018 | 2,224 |
| 9 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 10 | Poly(lactic acid) modifications | Progress in Polymer Science | 2010 | 1,795 |
| 11 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 12 | Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the α1A-voltage-dependent calcium channel | Nature Genetics | 1997 | 1,606 |
| 13 | An epigenetic biomarker of aging for lifespan and healthspan | Aging | 2018 | 1,552 |
| 14 | Parental Involvement and Students' Academic Achievement: A Meta-Analysis | Educational Psychology Review | 2001 | 1,518 |
| 15 | Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue. | Biological Psychiatry | 1999 | 1,395 |
| 16 | Neither .DELTA.- nor .LAMBDA.-tris(phenanthroline)ruthenium(II) binds to DNA by classical intercalation | Biochemistry | 1992 | 1,268 |
| 17 | LncRNA-mediated regulation of cell signaling in cancer | Oncogene | 2017 | 1,221 |
| 18 | A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse | British Journal of Cancer | 2000 | 1,154 |
| 19 | Tris(phenanthroline)ruthenium(II) enantiomer interactions with DNA: Mode and specificity of binding | Biochemistry | 1993 | 1,148 |
| 20 | Grading Strength of Recommendations and Quality of Evidence in Clinical Guidelines | Chest | 2006 | 1,146 |
| 21 | DNA methylation GrimAge strongly predicts lifespan and healthspan | Aging | 2019 | 1,128 |
| 22 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,124 |
| 23 | Polyamine transporter potABCD is required for virulence of encapsulated but not nonencapsulated Streptococcus pneumoniae | PLoS ONE | 2017 | 1,124 |
| 24 | Management of Spontaneous Pneumothorax | Chest | 2001 | 1,119 |
| 25 | Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program | Nature | 2021 | 1,069 |
| 26 | Preeclampsia | Circulation Research | 2019 | 1,019 |
| 27 | Trinucleotide repeat length instability and age of onset in Huntington's disease | Nature Genetics | 1993 | 1,008 |
| 28 | CARE guidelines for case reports: explanation and elaboration document | Journal of Clinical Epidemiology | 2017 | 993 |
| 29 | The Metabolic Syndrome and 11-Year Risk of Incident Cardiovascular Disease in the Atherosclerosis Risk in Communities Study | Diabetes Care | 2005 | 988 |
| 30 | Gender Differences in the Regulation of Blood Pressure | Hypertension | 2001 | 986 |
| 31 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 32 | Assessing differential impacts of COVID-19 on black communities | Annals of Epidemiology | 2020 | 944 |
| 33 | Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells | Developmental Cell | 2006 | 915 |
| 34 | Interactions between extracellular matrix and growth factors in wound healing | Wound Repair and Regeneration | 2009 | 891 |
| 35 | Increased Diagnosis of Primary Aldosteronism, Including Surgically Correctable Forms, in Centers from Five Continents | Journal of Clinical Endocrinology and Metabolism | 2004 | 862 |
| 36 | Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction | Journal of Neuroscience | 1998 | 836 |
| 37 | Pediatric Gastroesophageal Reflux Clinical Practice Guidelines | Journal of Pediatric Gastroenterology and Nutrition | 2018 | 817 |
| 38 | Carotid Intima-Media Thickness and Presence or Absence of Plaque Improves Prediction of Coronary Heart Disease Risk | Journal of the American College of Cardiology | 2010 | 794 |
| 39 | Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia | JAMA - Journal of the American Medical Association | 2019 | 786 |
| 40 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 41 | Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction | New England Journal of Medicine | 2020 | 753 |
| 42 | Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells | Biological Psychiatry | 2000 | 750 |
| 43 | Validation of the Delirium Rating Scale-Revised-98 | Journal of Neuropsychiatry and Clinical Neurosciences | 2001 | 730 |
| 44 | Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia | Journal of the American College of Cardiology | 2016 | 723 |
| 45 | Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes | JAMA Psychiatry | 2015 | 700 |
| 46 | New insights into the genetic etiology of Alzheimer’s disease and related dementias | Nature Genetics | 2022 | 700 |
| 47 | Glomerular number and size in autopsy kidneys: The relationship to birth weight | Kidney International | 2003 | 647 |
| 48 | Decreased expression of synapse-related genes and loss of synapses in major depressive disorder | Nature Medicine | 2012 | 640 |
| 49 | Staphylococcus aureus CC398: Host Adaptation and Emergence of Methicillin Resistance in Livestock | MBio | 2012 | 638 |
| 50 | Chronic Leptin Infusion Increases Arterial Pressure | Hypertension | 1998 | 636 |
