| # | Title | Journal | Year | Citations |
|---|
| 1 | Molecular replacement withMOLREP | Acta Crystallographica Section D: Biological Crystallography | 2010 | 3,149 |
| 2 | The Genome Sequence of the Malaria MosquitoAnopheles gambiae | Science | 2002 | 1,859 |
| 3 | DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae | Nature | 2000 | 1,723 |
| 4 | Emerging Marine Diseases--Climate Links and Anthropogenic Factors | Science | 1999 | 1,533 |
| 5 | BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities | Nucleic Acids Research | 2007 | 1,493 |
| 6 | Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8 | Science | 2004 | 1,197 |
| 7 | Global Climate and Infectious Disease: The Cholera Paradigm | Science | 1996 | 1,123 |
| 8 | HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS | Nature | 2007 | 1,068 |
| 9 | The Genome of the Sea Urchin Strongylocentrotus purpuratus | Science | 2006 | 1,018 |
| 10 | Catalytic specificity of protein-tyrosine kinases is critical for selective signalling | Nature | 1995 | 932 |
| 11 | Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death | Nature | 2003 | 926 |
| 12 | Autophagy: dual roles in life and death? | Nature Reviews Molecular Cell Biology | 2005 | 889 |
| 13 | Arthropod relationships revealed by phylogenomic analysis of nuclear protein-coding sequences | Nature | 2010 | 858 |
| 14 | Calculation of Protein-Ligand Binding Affinities | Annual Review of Biophysics and Biomolecular Structure | 2007 | 807 |
| 15 | The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria | Nature | 2003 | 760 |
| 16 | Neuroendocrinology of reproduction in teleost fish | General and Comparative Endocrinology | 2010 | 707 |
| 17 | Metal-enhanced fluorescence: an emerging tool in biotechnology | Current Opinion in Biotechnology | 2005 | 702 |
| 18 | Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma | Journal of Experimental Medicine | 2006 | 700 |
| 19 | The genomic basis of trophic strategy in marine bacteria | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 685 |
| 20 | FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death | Cell | 2003 | 683 |
| 21 | Biofabrication with Chitosan | Biomacromolecules | 2005 | 667 |
| 22 | SNPs, protein structure, and disease | Human Mutation | 2001 | 649 |
| 23 | SLP-2 is required for stress-induced mitochondrial hyperfusion | EMBO Journal | 2009 | 639 |
| 24 | Autophagic programmed cell death by selective catalase degradation | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 619 |
| 25 | Effects of Global Climate on Infectious Disease: the Cholera Model | Clinical Microbiology Reviews | 2002 | 610 |
| 26 | CAPRI: A Critical Assessment of PRedicted Interactions | Proteins: Structure, Function and Bioinformatics | 2003 | 586 |
| 27 | An effective fragment method for modeling solvent effects in quantum mechanical calculations | Journal of Chemical Physics | 1996 | 578 |
| 28 | Calcium sparks in smooth muscle | American Journal of Physiology - Cell Physiology | 2000 | 571 |
| 29 | Ions in water: Characterizing the forces that control chemical processes and biological structure | Biophysical Chemistry | 2007 | 556 |
| 30 | Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in Drosophila | Cell | 2007 | 547 |
| 31 | A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy–entropy compensation | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 534 |
| 32 | Calmodulin kinase II inhibition protects against structural heart disease | Nature Medicine | 2005 | 526 |
| 33 | Fluorescent Core−Shell Ag@SiO2Nanocomposites for Metal-Enhanced Fluorescence and Single Nanoparticle Sensing Platforms | Journal of the American Chemical Society | 2007 | 526 |
| 34 | The V3 domain of the HIV–1 gp120 envelope glycoprotein is critical for chemokine–mediated blockade of infection | Nature Medicine | 1996 | 524 |
| 35 | The immune gene repertoire encoded in the purple sea urchin genome | Developmental Biology | 2006 | 513 |
| 36 | The Protein Data Bank and the challenge of structural genomics | Nature Structural Biology | 2000 | 511 |
| 37 | Global spread of microorganisms by ships | Nature | 2000 | 509 |
| 38 | Hypovirulence: Mycoviruses at the fungal–plant interface | Nature Reviews Microbiology | 2005 | 507 |
| 39 | Denitrification in recirculating systems: Theory and applications | Aquacultural Engineering | 2006 | 466 |
| 40 | Low-temperature extremophiles and their applications | Current Opinion in Biotechnology | 2002 | 461 |
| 41 | Roles of galectins in infection | Nature Reviews Microbiology | 2009 | 459 |
| 42 | Identification of a Novel Acidic Mammalian Chitinase Distinct from Chitotriosidase | Journal of Biological Chemistry | 2001 | 442 |
| 43 | Human β-defensins | Cellular and Molecular Life Sciences | 2006 | 442 |
| 44 | A large-scale experiment to assess protein structure prediction methods | Proteins: Structure, Function and Bioinformatics | 1995 | 440 |
| 45 | Loss of Protein Structure Stability as a Major Causative Factor in Monogenic Disease | Journal of Molecular Biology | 2005 | 438 |
| 46 | A decade of CASP: progress, bottlenecks and prognosis in protein structure prediction | Current Opinion in Structural Biology | 2005 | 435 |
| 47 | An all-atom distance-dependent conditional probability discriminatory function for protein structure prediction 1 1Edited by F. Cohen | Journal of Molecular Biology | 1998 | 429 |
| 48 | Accelerated Poisson-Boltzmann calculations for static and dynamic systems | Journal of Computational Chemistry | 2002 | 421 |
| 49 | THE EVOLUTION OF ADAPTIVE IMMUNITY | Annual Review of Immunology | 2006 | 420 |
| 50 | Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environment | Nature | 2004 | 415 |
