| # | Title | Journal | Year | Citations |
|---|
| 1 | Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption-II | Addiction | 1993 | 10,134 |
| 2 | Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease | Cell | 2017 | 4,081 |
| 3 | The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models | Bioinformatics | 2003 | 2,811 |
| 4 | Expansion of the eukaryotic proteome by alternative splicing | Nature | 2010 | 1,787 |
| 5 | Bone Tissue Engineering: Recent Advances and Challenges | Critical Reviews in Biomedical Engineering | 2012 | 1,758 |
| 6 | Sirtuin activators mimic caloric restriction and delay ageing in metazoans | Nature | 2004 | 1,742 |
| 7 | Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue | Science | 2001 | 1,727 |
| 8 | Biomedical applications of biodegradable polymers | Journal of Polymer Science, Part B: Polymer Physics | 2011 | 1,718 |
| 9 | Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum | Nature | 1991 | 1,712 |
| 10 | Resistance of Bacillus Endospores to Extreme Terrestrial and Extraterrestrial Environments | Microbiology and Molecular Biology Reviews | 2000 | 1,656 |
| 11 | The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2014 | 1,638 |
| 12 | Ehlers-Danlos syndromes: Revised nosology, Villefranche, 1997 | American Journal of Medical Genetics Part A | 1998 | 1,624 |
| 13 | State of the art of zirconia for dental applications | Dental Materials | 2008 | 1,589 |
| 14 | Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis | Nature Medicine | 2001 | 1,555 |
| 15 | Mechanism of Assembly of the Outer Membrane of Salmonella typhimurium | Journal of Biological Chemistry | 1972 | 1,467 |
| 16 | Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo | Nature Immunology | 2000 | 1,443 |
| 17 | The developmental transcriptome of Drosophila melanogaster | Nature | 2011 | 1,379 |
| 18 | Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2 | Science | 1999 | 1,364 |
| 19 | The use of gold nanoparticles to enhance radiotherapy in mice | Physics in Medicine and Biology | 2004 | 1,355 |
| 20 | Pathogenesis of osteoporosis: concepts, conflicts, and prospects | Journal of Clinical Investigation | 2005 | 1,348 |
| 21 | Loss of Independence in Activities of Daily Living in Older Adults Hospitalized with Medical Illnesses: Increased Vulnerability with Age | Journal of the American Geriatrics Society | 2003 | 1,254 |
| 22 | Expanded encyclopaedias of DNA elements in the human and mouse genomes | Nature | 2020 | 1,252 |
| 23 | Sir2 mediates longevity in the fly through a pathway related to calorie restriction | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 1,249 |
| 24 | Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms | Nature Biotechnology | 2003 | 1,221 |
| 25 | Perspectives on cancer therapy-induced mucosal injury | Cancer | 2004 | 1,214 |
| 26 | Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals | Journal of Applied Microbiology | 2006 | 1,204 |
| 27 | Iron and cancer: more ore to be mined | Nature Reviews Cancer | 2013 | 1,168 |
| 28 | Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling | Journal of Biological Chemistry | 2005 | 1,163 |
| 29 | Alternative splicing: increasing diversity in the proteomic world | Trends in Genetics | 2001 | 1,120 |
| 30 | Comorbidity of DSM-IV Pathological Gambling and Other Psychiatric Disorders | Journal of Clinical Psychiatry | 2005 | 1,084 |
| 31 | Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large‐scale meta‐analysis of 3,211,768 patients and 113,383,368 controls | World Psychiatry | 2017 | 1,082 |
| 32 | Treatment of Periodontitis and Endothelial Function | New England Journal of Medicine | 2007 | 1,055 |
| 33 | Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model | Neuroscience | 1989 | 1,046 |
| 34 | 20-Year Outcomes Following Conservative Management of Clinically Localized Prostate Cancer | JAMA - Journal of the American Medical Association | 2005 | 1,027 |
| 35 | Complex Trauma in Children and Adolescents | Psychiatric Annals | 2005 | 1,016 |
| 36 | The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex | Molecular Cell | 1999 | 964 |
| 37 | Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in Optineurin | Science | 2002 | 962 |
| 38 | Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate | Cell | 1999 | 951 |
| 39 | Polyphenolic Substance of Mytilus edulis: Novel Adhesive Containing L-Dopa and Hydroxyproline | Science | 1981 | 948 |
| 40 | Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells | Cell | 1979 | 946 |
| 41 | Sorting out the complexity of SR protein functions | Rna | 2000 | 922 |
| 42 | RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex | Cell | 2009 | 919 |
| 43 | Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry | Nature Biotechnology | 2001 | 913 |
| 44 | Three-Dimensional High-Resolution Second-Harmonic Generation Imaging of Endogenous Structural Proteins in Biological Tissues | Biophysical Journal | 2002 | 889 |
| 45 | CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription | Cell | 2015 | 881 |
| 46 | Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation | Cell Reports | 2014 | 866 |
| 47 | Stabilized zirconia as a structural ceramic: An overview☆ | Dental Materials | 2008 | 855 |
| 48 | Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: early analysis of a non-randomised, open-label, phase 2 trial | Lancet Oncology, The | 2016 | 846 |
| 49 | Validation of the alcohol, smoking and substance involvement screening test (ASSIST) | Addiction | 2008 | 825 |
| 50 | Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche | Nature | 2009 | 800 |
