| # | Title | Journal | Year | Citations |
|---|
| 1 | Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging | Journal of the American Society of Echocardiography | 2015 | 10,755 |
| 2 | Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiography, a Branch of the European Society of Cardiology | Journal of the American Society of Echocardiography | 2005 | 10,110 |
| 3 | Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer | Science | 1989 | 6,473 |
| 4 | Surviving Sepsis Campaign | Critical Care Medicine | 2013 | 6,362 |
| 5 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 | Intensive Care Medicine | 2013 | 3,906 |
| 6 | Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial | Lancet, The | 2002 | 3,835 |
| 7 | Neuronal ensemble control of prosthetic devices by a human with tetraplegia | Nature | 2006 | 2,979 |
| 8 | Human Anti–Tumor Necrosis Factor Monoclonal Antibody (Adalimumab) in Crohn’s Disease: the CLASSIC-I Trial | Gastroenterology | 2006 | 1,523 |
| 9 | TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 1,202 |
| 10 | A Psychometric Toolbox for Testing Validity and Reliability | Journal of Nursing Scholarship | 2007 | 1,195 |
| 11 | Extent and determinants of error in doctors' prognoses in terminally ill patients: prospective cohort study Commentary: Why do doctors overestimate? Commentary: Prognoses should be based on proved indices not intuition | BMJ: British Medical Journal | 2000 | 1,188 |
| 12 | Rethinking ovarian cancer: recommendations for improving outcomes | Nature Reviews Cancer | 2011 | 1,084 |
| 13 | Quality of Cardiopulmonary Resuscitation During In-Hospital Cardiac Arrest | JAMA - Journal of the American Medical Association | 2005 | 1,060 |
| 14 | First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study | Lancet Oncology, The | 2017 | 1,034 |
| 15 | Surgical site infection: Incidence and impact on hospital utilization and treatment costs | American Journal of Infection Control | 2009 | 957 |
| 16 | Comparison of scheduled and episodic treatment strategies of infliximab in Crohn’s disease | Gastroenterology | 2004 | 929 |
| 17 | Integration of impulsivity and positive mood to predict risky behavior: Development and validation of a measure of positive urgency. | Psychological Assessment | 2007 | 907 |
| 18 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis | Lancet Oncology, The | 2011 | 847 |
| 19 | Clinical Practice Guideline | Otolaryngology - Head and Neck Surgery | 2015 | 832 |
| 20 | Serious Infections and Mortality in Association With Therapies for Crohn’s Disease: TREAT Registry | Clinical Gastroenterology and Hepatology | 2006 | 831 |
| 21 | Inflammatory bowel disease: Epidemiology, pathogenesis, and therapeutic opportunities | Inflammatory Bowel Diseases | 2006 | 756 |
| 22 | Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial | Gut | 2011 | 750 |
| 23 | Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study | Lancet, The | 2021 | 711 |
| 24 | Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial | Lancet Neurology, The | 2014 | 707 |
| 25 | Maximum likelihood estimation of receiver operating characteristic (ROC) curves from continuously-distributed data | Lancet Neurology, The | 1998 | 693 |
| 26 | Cardiac-Resynchronization Therapy in Heart Failure with Narrow QRS Complexes | New England Journal of Medicine | 2007 | 654 |
| 27 | Serious Infection and Mortality in Patients With Crohn's Disease: More Than 5 Years of Follow-Up in the TREAT™ Registry | American Journal of Gastroenterology | 2012 | 652 |
| 28 | Does delirium contribute to poor hospital outcomes? | Journal of General Internal Medicine | 1998 | 651 |
| 29 | Chest Compression Rates During Cardiopulmonary Resuscitation Are Suboptimal | Circulation | 2005 | 650 |
| 30 | Focused Cardiac Ultrasound in the Emergent Setting: A Consensus Statement of the American Society of Echocardiography and American College of Emergency Physicians | Journal of the American Society of Echocardiography | 2010 | 636 |
| 31 | Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study | Lancet Oncology, The | 2020 | 620 |
| 32 | Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study | Lancet Oncology, The | 2019 | 611 |
| 33 | Effects of compression depth and pre-shock pauses predict defibrillation failure during cardiac arrest | Resuscitation | 2006 | 597 |
| 34 | Nivolumab vs investigator’s choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression | Oral Oncology | 2018 | 589 |
| 35 | Incidence and importance of antibody responses to infliximab after maintenance or episodic treatment in Crohn’s disease | Clinical Gastroenterology and Hepatology | 2004 | 582 |
| 36 | Microchimerism and HLA-compatible relationships of pregnancy in scleroderma | Lancet, The | 1998 | 574 |
| 37 | Predicting 15-Year Prostate Cancer Specific Mortality After Radical Prostatectomy | Journal of Urology | 2011 | 574 |
| 38 | Safety and preliminary efficacy of venetoclax with decitabine or azacitidine in elderly patients with previously untreated acute myeloid leukaemia: a non-randomised, open-label, phase 1b study | Lancet Oncology, The | 2018 | 551 |
| 39 | American Society of Echocardiography recommendations for use of echocardiography in clinical trials | Journal of the American Society of Echocardiography | 2004 | 533 |
| 40 | Functional Expression and Mutations of c-Met and Its Therapeutic Inhibition with SU11274 and Small Interfering RNA in Non–Small Cell Lung Cancer | Cancer Research | 2005 | 530 |
| 41 | Efficacy of Biological Therapies in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis | American Journal of Gastroenterology | 2011 | 523 |
| 42 | Prognostic Factors for Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage | Stroke | 2007 | 515 |
| 43 | Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22 | Science | 1992 | 506 |
| 44 | Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 | JAMA - Journal of the American Medical Association | 2021 | 498 |
| 45 | SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70 | Molecular and Cellular Biology | 2008 | 490 |
| 46 | Changes in the Prevalence of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients With Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation | Gastroenterology | 2017 | 487 |
| 47 | Implementing genomic medicine in the clinic: the future is here | Genetics in Medicine | 2013 | 472 |
| 48 | Early identification of HCV genotype 1 patients responding to 24 weeks peginterferon α-2a (40 kd)/ribavirin therapy | Hepatology | 2006 | 469 |
| 49 | Prognostic Disclosure to Patients with Cancer near the End of Life | Annals of Internal Medicine | 2001 | 461 |
| 50 | From Social Structural Factors to Perceptions of Relationship Quality and Loneliness: The Chicago Health, Aging, and Social Relations Study | Journals of Gerontology - Series B Psychological Sciences and Social Sciences | 2008 | 460 |
