| # | Title | Journal | Year | Citations |
|---|
| 1 | Nuclear factor-κB in cancer development and progression | Nature | 2006 | 3,219 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 3 | NF-κB: linking inflammation and immunity to cancer development and progression | Nature Reviews Immunology | 2005 | 2,745 |
| 4 | Histone modifications at human enhancers reflect global cell-type-specific gene expression | Nature | 2009 | 2,225 |
| 5 | IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer | Cancer Cell | 2009 | 1,851 |
| 6 | Leptospirosis: a zoonotic disease of global importance | Lancet Infectious Diseases, The | 2003 | 1,828 |
| 7 | The NIH Roadmap Epigenomics Mapping Consortium | Nature Biotechnology | 2010 | 1,705 |
| 8 | Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis | Nature Medicine | 2004 | 1,542 |
| 9 | Fibroblast‐like synoviocytes: key effector cells in rheumatoid arthritis | Immunological Reviews | 2010 | 1,515 |
| 10 | Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification | Cell | 2011 | 1,462 |
| 11 | Prevalence of Fatty Liver in Children and Adolescents | Pediatrics | 2006 | 1,264 |
| 12 | Glucose feeds the TCA cycle via circulating lactate | Nature | 2017 | 1,112 |
| 13 | Reactive astrocyte nomenclature, definitions, and future directions | Nature Neuroscience | 2021 | 1,098 |
| 14 | Receptor downregulation and multivesicular-body sorting | Nature Reviews Molecular Cell Biology | 2002 | 1,089 |
| 15 | Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges | Psychopharmacology | 2001 | 969 |
| 16 | SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 | Cell | 2020 | 860 |
| 17 | Kawasaki syndrome | Lancet, The | 2004 | 849 |
| 18 | A high-resolution map of active promoters in the human genome | Nature | 2005 | 841 |
| 19 | Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer | Cell | 2006 | 835 |
| 20 | Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences | PLoS Biology | 2004 | 830 |
| 21 | The Role of Actigraphy in the Evaluation of Sleep Disorders | Sleep | 1995 | 819 |
| 22 | Signaling Pathways for Cardiac Hypertrophy and Failure | New England Journal of Medicine | 1999 | 790 |
| 23 | Eukaryotic DNA mismatch repair | Current Opinion in Genetics and Development | 1999 | 781 |
| 24 | Association of Electronic Cigarette Use With Initiation of Combustible Tobacco Product Smoking in Early Adolescence | JAMA - Journal of the American Medical Association | 2015 | 772 |
| 25 | Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain | Nature Biotechnology | 2018 | 762 |
| 26 | Phosphoinositides as Regulators in Membrane Traffic | Science | 1996 | 719 |
| 27 | Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors | Nature Reviews Rheumatology | 2013 | 715 |
| 28 | The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy | Acta Neuropathologica | 2016 | 708 |
| 29 | Global epidemiology of HIV among female sex workers: influence of structural determinants | Lancet, The | 2015 | 674 |
| 30 | NF- B as a Critical Link Between Inflammation and Cancer | Cold Spring Harbor Perspectives in Biology | 2009 | 655 |
| 31 | Anifrolumab, an Anti–Interferon‐α Receptor Monoclonal Antibody, in Moderate‐to‐Severe Systemic Lupus Erythematosus | Arthritis and Rheumatology | 2017 | 634 |
| 32 | Toll‐like receptors and adaptor molecules in liver disease: Update | Hepatology | 2008 | 614 |
| 33 | Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling | Nature | 2011 | 583 |
| 34 | Intrauterine growth restriction | Obstetrics and Gynecology | 2002 | 580 |
| 35 | Reparative inflammation takes charge of tissue regeneration | Nature | 2016 | 570 |
| 36 | Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities | JAMA - Journal of the American Medical Association | 2018 | 562 |
| 37 | 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response | Nature | 2011 | 557 |
| 38 | Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? | Arthritis and Rheumatism | 1996 | 551 |
| 39 | Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs) | Journal of Clinical Investigation | 2007 | 538 |
| 40 | Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults | JAMA - Journal of the American Medical Association | 2016 | 533 |
| 41 | Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist | Lancet, The | 2004 | 526 |
| 42 | Logistic regression in the medical literature: | Journal of Clinical Epidemiology | 2001 | 511 |
| 43 | Endogenous Sex Steroids and Bone Mineral Density in Older Women and Men: The Rancho Bernardo Study | Journal of Bone and Mineral Research | 1997 | 502 |
| 44 | The immune cell landscape in kidneys of patients with lupus nephritis | Nature Immunology | 2019 | 501 |
| 45 | Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 500 |
| 46 | Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults | JAMA - Journal of the American Medical Association | 2018 | 486 |
| 47 | Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma | Nature Communications | 2015 | 484 |
| 48 | Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS) | Movement Disorders | 2004 | 481 |
| 49 | Realistic expectations of prepulse inhibition in translational models for schizophrenia research | Psychopharmacology | 2008 | 479 |
| 50 | American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock | Critical Care Medicine | 2017 | 475 |
