| # | Title | Journal | Year | Citations |
|---|
| 1 | Myocardial Fatty Acid Metabolism in Health and Disease | Physiological Reviews | 2010 | 1,643 |
| 2 | Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System | Circulation Research | 2020 | 1,478 |
| 3 | International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts | Blood | 2015 | 982 |
| 4 | Cardio-renal syndromes: report from the consensus conference of the Acute Dialysis Quality Initiative | European Heart Journal | 2010 | 797 |
| 5 | 2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult | Canadian Journal of Cardiology | 2016 | 775 |
| 6 | 2012 Update of the Canadian Cardiovascular Society Guidelines for the Diagnosis and Treatment of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult | Canadian Journal of Cardiology | 2013 | 680 |
| 7 | Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin | Nature Medicine | 2013 | 674 |
| 8 | Drug treatments for obesity: orlistat, sibutramine, and rimonabant | Lancet, The | 2007 | 648 |
| 9 | Sex differences in schizophrenia, a review of the literature | Acta Psychiatrica Scandinavica | 2000 | 610 |
| 10 | Inflammation, Growth Factors, and Pulmonary Vascular Remodeling | Journal of the American College of Cardiology | 2009 | 605 |
| 11 | Cardiovascular remodelling in coronary artery disease and heart failure | Lancet, The | 2014 | 589 |
| 12 | Early acute kidney injury and sepsis: a multicentre evaluation | Critical Care | 2008 | 517 |
| 13 | Energy Metabolic Phenotype of the Cardiomyocyte During Development, Differentiation, and Postnatal Maturation | Journal of Cardiovascular Pharmacology | 2010 | 512 |
| 14 | A systematic review of randomized trials of disease management programs in heart failure | American Journal of Medicine | 2001 | 508 |
| 15 | Breast Cancer Subtypes and Response to Docetaxel in Node-Positive Breast Cancer: Use of an Immunohistochemical Definition in the BCIRG 001 Trial | Journal of Clinical Oncology | 2009 | 461 |
| 16 | 2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection | American Journal of Transplantation | 2016 | 451 |
| 17 | Meta-analysis: β-Blocker Dose, Heart Rate Reduction, and Death in Patients With Heart Failure | Annals of Internal Medicine | 2009 | 426 |
| 18 | A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients | Nephrology Dialysis Transplantation | 2007 | 423 |
| 19 | Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update) | Diabetes/Metabolism Research and Reviews | 2020 | 418 |
| 20 | Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial | Lancet, The | 2020 | 400 |
| 21 | The Relation Between Hyperglycemia and Outcomes in 2,471 Patients Admitted to the Hospital With Community-Acquired Pneumonia | Diabetes Care | 2005 | 390 |
| 22 | Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis | Lancet, The | 2013 | 388 |
| 23 | Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction | Circulation | 2010 | 383 |
| 24 | 2014 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation | Canadian Journal of Cardiology | 2014 | 382 |
| 25 | 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults | Canadian Journal of Cardiology | 2021 | 367 |
| 26 | Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy | British Journal of Pharmacology | 2014 | 361 |
| 27 | Hypertension prevalence, awareness, treatment and control in national surveys from England, the USA and Canada, and correlation with stroke and ischaemic heart disease mortality: a cross-sectional study | BMJ Open | 2013 | 360 |
| 28 | A Meta-Analysis of the Effect of Exercise Training on Left Ventricular Remodeling in Heart Failure Patients | Journal of the American College of Cardiology | 2007 | 353 |
| 29 | Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial | Lancet Neurology, The | 2012 | 351 |
| 30 | Continuous versus intermittent renal replacement therapy for critically ill patients with acute kidney injury: A meta-analysis* | Critical Care Medicine | 2008 | 342 |
| 31 | Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering | JAMA - Journal of the American Medical Association | 2018 | 339 |
| 32 | The Isolation of Nucleic Acids from Fixed, Paraffin-Embedded Tissues–Which Methods Are Useful When? | PLoS ONE | 2007 | 322 |
| 33 | Cardiogenic Shock Classification to Predict Mortality in the Cardiac Intensive Care Unit | Journal of the American College of Cardiology | 2019 | 314 |
| 34 | Impact of thrombolysis, intra-aortic balloon pump counterpulsation, and their combination in cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry | Journal of the American College of Cardiology | 2000 | 303 |
| 35 | The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials | American Journal of Medicine | 2002 | 299 |
| 36 | Targeting fatty acid and carbohydrate oxidation — A novel therapeutic intervention in the ischemic and failing heart | Biochimica Et Biophysica Acta - Molecular Cell Research | 2011 | 298 |
| 37 | Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption | Diabetes | 2010 | 296 |
| 38 | Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness | Intensive Care Medicine | 2010 | 294 |
| 39 | Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review | BMJ: British Medical Journal | 2007 | 293 |
| 40 | Randomised trials of secondary prevention programmes in coronary heart disease: systematic review | BMJ: British Medical Journal | 2001 | 286 |
| 41 | Prevalence, Risk Factors, and Outcomes of Delirium in Mechanically Ventilated Adults* | Critical Care Medicine | 2015 | 268 |
| 42 | Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy | Diabetes | 2010 | 264 |
| 43 | Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS | Journal of Molecular and Cellular Cardiology | 2014 | 263 |
| 44 | Guiding Principles for Chronic Total Occlusion Percutaneous Coronary Intervention | Circulation | 2019 | 263 |
| 45 | Inclusion of Sarcopenia Within MELD (MELD-Sarcopenia) and the Prediction of Mortality in Patients With Cirrhosis | Clinical and Translational Gastroenterology | 2015 | 261 |
| 46 | Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture | Nature Genetics | 2010 | 259 |
| 47 | The Emerging Role of Metabolomics in the Diagnosis and Prognosis of Cardiovascular Disease | Journal of the American College of Cardiology | 2016 | 259 |
| 48 | Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial | BMJ, The | 2021 | 250 |
| 49 | Poststroke Aphasia Frequency, Recovery, and Outcomes: A Systematic Review and Meta-Analysis | Archives of Physical Medicine and Rehabilitation | 2016 | 248 |
| 50 | Normative data on selected neuropsychological measures from a nonclinical sample | Journal of Clinical Psychology | 1985 | 246 |
