| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 2 | Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability | Science | 1995 | 2,173 |
| 3 | Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer | New England Journal of Medicine | 2010 | 2,066 |
| 4 | Cross-national prevalence and risk factors for suicidal ideation, plans and attempts | British Journal of Psychiatry | 2008 | 1,993 |
| 5 | Inflammatory bowel disease: Etiology and pathogenesis | Gastroenterology | 1998 | 1,955 |
| 6 | Suppression of human colorectal carcinoma cell growth by wild-type p53 | Science | 1990 | 1,723 |
| 7 | Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation | Immunity | 2014 | 1,692 |
| 8 | Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. | Radiology | 1988 | 1,667 |
| 9 | European guidance for the diagnosis and management of osteoporosis in postmenopausal women | Osteoporosis International | 2013 | 1,560 |
| 10 | Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans | Acta Tropica | 2010 | 1,508 |
| 11 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs | Annals of the Rheumatic Diseases | 2010 | 1,429 |
| 12 | Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. | Journal of Bone and Joint Surgery - Series A | 1994 | 1,404 |
| 13 | Biofilm Formation by the Fungal Pathogen Candida albicans : Development, Architecture, and Drug Resistance | Journal of Bacteriology | 2001 | 1,384 |
| 14 | Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance | Clinical Microbiology Reviews | 1999 | 1,367 |
| 15 | Death toll exceeded 70,000 in Europe during the summer of 2003 | Comptes Rendus - Biologies | 2008 | 1,331 |
| 16 | Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial | Lancet Oncology, The | 2015 | 1,269 |
| 17 | Diagnostic Performance of Noninvasive Fractional Flow Reserve Derived From Coronary Computed Tomography Angiography in Suspected Coronary Artery Disease | Journal of the American College of Cardiology | 2014 | 1,240 |
| 18 | Management of Spontaneous Pneumothorax | Chest | 2001 | 1,119 |
| 19 | Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study | Gastroenterology | 2010 | 1,056 |
| 20 | Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial | Lancet, The | 2004 | 1,053 |
| 21 | Thrombocytopenia and prognosis in intensive care | Critical Care Medicine | 2000 | 1,046 |
| 22 | Global Challenge of Multidrug-ResistantAcinetobacter baumannii | Antimicrobial Agents and Chemotherapy | 2007 | 1,027 |
| 23 | European guidance for the diagnosis and management of osteoporosis in postmenopausal women | Osteoporosis International | 2019 | 1,020 |
| 24 | Clinical Trial Substantiates the Predictive Value of O-6-Methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastoma Patients Treated with Temozolomide | Clinical Cancer Research | 2004 | 1,014 |
| 25 | Role of Rifampin for Treatment of Orthopedic Implant–Related Staphylococcal Infections A Randomized Controlled Trial | JAMA - Journal of the American Medical Association | 1998 | 940 |
| 26 | Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale | New England Journal of Medicine | 2012 | 916 |
| 27 | Peripheral muscle weakness contributes to exercise limitation in COPD. | American Journal of Respiratory and Critical Care Medicine | 1996 | 867 |
| 28 | Robinson anterior cervical discectomy and arthrodesis for cervical radiculopathy. Long-term follow-up of one hundred and twenty-two patients. | Journal of Bone and Joint Surgery - Series A | 1993 | 841 |
| 29 | Aneurysmal Subarachnoid Hemorrhage | New England Journal of Medicine | 2006 | 834 |
| 30 | Cervical cancer | Lancet, The | 2003 | 831 |
| 31 | Evidence for an immune response in major depression: A review and hypothesis | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 1995 | 820 |
| 32 | Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes | Diabetes | 2001 | 760 |
| 33 | Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy | American Journal of Medicine | 1989 | 756 |
| 34 | Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study | Lancet Oncology, The | 2015 | 753 |
| 35 | Air Pollution and Cardiovascular Disease | Journal of the American College of Cardiology | 2018 | 749 |
| 36 | Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with warfarin ∗∗Access the “Journal Club” discussion of this paper at http://www.elsevier.com/locate/ajmselect/ | American Journal of Medicine | 1998 | 734 |
| 37 | Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth | Cell | 2013 | 729 |
| 38 | APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy | Journal of the American Society of Nephrology: JASN | 2011 | 713 |
| 39 | In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993) | Blood | 2008 | 702 |
| 40 | Clinical Relevance of MGMT in the Treatment of Cancer | Journal of Clinical Oncology | 2002 | 681 |
| 41 | International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer | Gut | 2013 | 672 |
| 42 | NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality | European Journal of Cancer | 2012 | 661 |
| 43 | Does delirium contribute to poor hospital outcomes? | Journal of General Internal Medicine | 1998 | 651 |
| 44 | The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation | Nature Immunology | 2014 | 651 |
| 45 | Are Readmissions to the Intensive Care Unit a Useful Measure of Hospital Performance? | Medical Care | 1999 | 646 |
| 46 | Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers | Hepatology | 2004 | 644 |
| 47 | IOF position statement: vitamin D recommendations for older adults | Osteoporosis International | 2010 | 634 |
| 48 | Sonography of the Scrotum | Radiology | 2003 | 607 |
| 49 | A Consensus Report of the Role of Serum Thyroglobulin as a Monitoring Method for Low-Risk Patients with Papillary Thyroid Carcinoma | Journal of Clinical Endocrinology and Metabolism | 2003 | 605 |
| 50 | Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane | Journal of Cell Biology | 2003 | 602 |
