| # | Title | Journal | Year | Citations |
|---|
| 1 | A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD | Neuron | 2011 | 3,833 |
| 2 | Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest | New England Journal of Medicine | 2013 | 2,805 |
| 3 | The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma | American Journal of Surgical Pathology | 2005 | 2,334 |
| 4 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 5 | Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 | Cell | 2020 | 1,561 |
| 6 | Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium | Clinical Infectious Diseases | 2020 | 1,429 |
| 7 | British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults | Gut | 2019 | 1,353 |
| 8 | Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe | Lancet, The | 2005 | 1,321 |
| 9 | Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution | Nature | 2017 | 1,287 |
| 10 | Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors | Nature Genetics | 2002 | 1,239 |
| 11 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 12 | Difficult Airway Society guidelines for management of the unanticipated difficult intubation | Anaesthesia | 2004 | 1,000 |
| 13 | Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium | Lancet Infectious Diseases, The | 2019 | 970 |
| 14 | Guidelines for the management of thyroid cancer | Clinical Endocrinology | 2014 | 961 |
| 15 | Clostridium difficile infection in Europe: a hospital-based survey | Lancet, The | 2011 | 924 |
| 16 | Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist | Arthritis and Rheumatism | 1998 | 920 |
| 17 | The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial | Lancet, The | 2007 | 850 |
| 18 | Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III | Nature Genetics | 1997 | 812 |
| 19 | Survival as a function of HbA1c in people with type 2 diabetes: a retrospective cohort study | Lancet, The | 2010 | 770 |
| 20 | Psychological treatments for chronic post-traumatic stress disorder | British Journal of Psychiatry | 2007 | 758 |
| 21 | Preexisting and de novo humoral immunity to SARS-CoV-2 in humans | Science | 2020 | 735 |
| 22 | Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation | Blood | 2007 | 646 |
| 23 | A human homologue of the Drosophila eyes absent gene underlies Branchio-Oto-Renal (BOR) syndrome and identifies a novel gene family | Nature Genetics | 1997 | 628 |
| 24 | The Prevalence, Severity, and Impact of Painful Diabetic Peripheral Neuropathy in Type 2 Diabetes | Diabetes Care | 2006 | 626 |
| 25 | EFNS guidelines on neurostimulation therapy for neuropathic pain | European Journal of Neurology | 2007 | 601 |
| 26 | Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy | Lancet, The | 1995 | 599 |
| 27 | Comparison of phenotypes of polycystic kidney disease types 1 and 2 | Lancet, The | 1999 | 547 |
| 28 | 2014 European Thyroid Association Guidelines for the Management of Subclinical Hypothyroidism in Pregnancy and in Children | European Thyroid Journal | 2014 | 534 |
| 29 | The rare coagulation disorders - review with guidelines for management from the United Kingdom Haemophilia Centre Doctors' Organisation | Haemophilia | 2004 | 516 |
| 30 | Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum | Nature Genetics | 2000 | 512 |
| 31 | Effect of an Indwelling Pleural Catheter vs Chest Tube and Talc Pleurodesis for Relieving Dyspnea in Patients With Malignant Pleural Effusion | JAMA - Journal of the American Medical Association | 2012 | 508 |
| 32 | BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis | Human Reproduction Update | 2013 | 507 |
| 33 | EBV Positive Mucocutaneous Ulcer—A Study of 26 Cases Associated With Various Sources of Immunosuppression | American Journal of Surgical Pathology | 2010 | 500 |
| 34 | Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial | Arthritis and Rheumatism | 2002 | 496 |
| 35 | Recommendations for the management of patients after heart valve surgery | European Heart Journal | 2005 | 488 |
| 36 | PCR Targeted to the 16S-23S rRNA Gene Intergenic Spacer Region of Clostridium difficile and Construction of a Library Consisting of 116 Different PCR Ribotypes | Journal of Clinical Microbiology | 1999 | 486 |
| 37 | Transdermal Nicotine for Active Ulcerative Colitis | New England Journal of Medicine | 1994 | 466 |
| 38 | Germline mutations in RAD51D confer susceptibility to ovarian cancer | Nature Genetics | 2011 | 460 |
| 39 | Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1 | American Journal of Medical Genetics, Part A | 2015 | 447 |
| 40 | A Spectrum of ABCC6 Mutations Is Responsible for Pseudoxanthoma Elasticum | American Journal of Human Genetics | 2001 | 442 |
| 41 | The Appropriate Use of Neurostimulation of the Spinal Cord and Peripheral Nervous System for the Treatment of Chronic Pain and Ischemic Diseases: The Neuromodulation Appropriateness Consensus Committee | Neuromodulation | 2014 | 441 |
| 42 | Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome) | Nature Genetics | 2011 | 440 |
| 43 | Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial | Lancet Oncology, The | 2015 | 433 |
| 44 | Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: 2012 Update of the Consensus Statement from the International Mesothelioma Interest Group | Archives of Pathology and Laboratory Medicine | 2013 | 422 |
| 45 | Characterization of Mutations in Patients with Multiple Endocrine Neoplasia Type 1 | American Journal of Human Genetics | 1998 | 421 |
| 46 | Rectal Carcinoma: Thin-Section MR Imaging for Staging in 28 Patients | Radiology | 1999 | 416 |
| 47 | Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile | FEMS Microbiology Letters | 2000 | 415 |
| 48 | Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database | Nature Genetics | 2014 | 410 |
| 49 | International Evidence-Based Recommendations for Focused Cardiac Ultrasound | Journal of the American Society of Echocardiography | 2014 | 409 |
| 50 | Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial | Lancet Oncology, The | 2013 | 407 |
