| # | Title | Journal | Year | Citations |
|---|
| 1 | The Ras superfamily at a glance | Journal of Cell Science | 2005 | 1,222 |
| 2 | 4th ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4) | Annals of Oncology | 2018 | 891 |
| 3 | 3rd ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3) | Annals of Oncology | 2017 | 865 |
| 4 | 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) | Annals of Oncology | 2020 | 761 |
| 5 | Prognostic value of sarcopenia in adults with solid tumours: A meta-analysis and systematic review | European Journal of Cancer | 2016 | 733 |
| 6 | Church-Based Health Promotion Interventions: Evidence and Lessons Learned | Annual Review of Public Health | 2007 | 655 |
| 7 | Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? | Nature Reviews Cancer | 2010 | 654 |
| 8 | Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells | Nature | 1994 | 618 |
| 9 | Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial | Lancet Oncology, The | 2017 | 561 |
| 10 | Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 489 |
| 11 | Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development | Development (Cambridge) | 1999 | 478 |
| 12 | Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS | EMBO Reports | 2011 | 468 |
| 13 | Testosterone and Dihydrotestosterone Tissue Levels in Recurrent Prostate Cancer | Clinical Cancer Research | 2005 | 457 |
| 14 | New insights into the regulation and cellular functions of the ARP2/3 complex | Nature Reviews Molecular Cell Biology | 2013 | 434 |
| 15 | Patient-Reported Outcomes — Harnessing Patients’ Voices to Improve Clinical Care | New England Journal of Medicine | 2017 | 426 |
| 16 | Carbamazepine, HLA-B*1502 and risk of Stevens–Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations | Pharmacogenomics | 2008 | 421 |
| 17 | Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability | Journal of Biological Chemistry | 2002 | 375 |
| 18 | The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits | International Journal of Biological Sciences | 2005 | 369 |
| 19 | Accurate sampling and deep sequencing of the HIV-1 protease gene using a Primer ID | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 358 |
| 20 | Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling | EMBO Journal | 2003 | 356 |
| 21 | Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice | Journal of Neuroimmunology | 1998 | 346 |
| 22 | Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research | Breast Cancer Research and Treatment | 1995 | 344 |
| 23 | The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions | Journal of Virology | 1994 | 335 |
| 24 | In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation | Cell Metabolism | 2013 | 280 |
| 25 | Ras and Rho regulation of the cell cycle and oncogenesis | Cancer Letters | 2001 | 277 |
| 26 | Implementation of Patient-Reported Outcomes in Routine Medical Care | American Society of Clinical Oncology Educational Book / ASCO American Society of Clinical Oncology Meeting | 2018 | 260 |
| 27 | Current Landscape of Immunotherapy in Breast Cancer | JAMA Oncology | 2019 | 260 |
| 28 | HIV reservoirs: what, where and how to target them | Nature Reviews Microbiology | 2016 | 259 |
| 29 | The principles of directed cell migration | Nature Reviews Molecular Cell Biology | 2021 | 252 |
| 30 | Safety and Tolerability of PD-1/PD-L1 Inhibitors Compared with Chemotherapy in Patients with Advanced Cancer: A Meta-Analysis | Oncologist | 2017 | 244 |
| 31 | Comparison of efficacy of immune checkpoint inhibitors (ICIs) between younger and older patients: A systematic review and meta-analysis | Cancer Treatment Reviews | 2016 | 242 |
| 32 | Prognostic value of lymphocyte-to-monocyte ratio in patients with solid tumors: A systematic review and meta-analysis | Cancer Treatment Reviews | 2015 | 239 |
| 33 | Molecular and Cellular Heterogeneity in Breast Cancer | American Journal of Pathology | 2013 | 227 |
| 34 | Mechanisms of Human Hepatocarcinogenesis | Current Molecular Medicine | 2003 | 225 |
| 35 | An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting | Molecular Cell | 2013 | 221 |
| 36 | Best Practices in Cancer Nanotechnology: Perspective from NCI Nanotechnology Alliance | Clinical Cancer Research | 2012 | 220 |
| 37 | Longitudinal Predictors of Human Papillomavirus Vaccine Initiation Among Adolescent Girls in a High-Risk Geographic Area | Sexually Transmitted Diseases | 2011 | 219 |
| 38 | Biomarkers for Response to Neoadjuvant Chemoradiation for Rectal Cancer | International Journal of Radiation Oncology Biology Physics | 2009 | 215 |
| 39 | Skeletal Muscle Measures as Predictors of Toxicity, Hospitalization, and Survival in Patients with Metastatic Breast Cancer Receiving Taxane-Based Chemotherapy | Clinical Cancer Research | 2017 | 214 |
| 40 | Protein prenylation: more than just glue? | Current Opinion in Cell Biology | 1992 | 212 |
| 41 | Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins | BioEssays | 1995 | 205 |
| 42 | Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: a five-arm phase 2 study | Lancet Oncology, The | 2015 | 205 |
| 43 | AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival | Cell Metabolism | 2016 | 195 |
| 44 | Viral effects on the content and function of extracellular vesicles | Nature Reviews Microbiology | 2017 | 195 |
| 45 | Aberrant function of the Ras signal transduction pathway in human breast cancer | Breast Cancer Research and Treatment | 1995 | 194 |
| 46 | DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines | Molecular Cancer | 2008 | 192 |
| 47 | Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development | Development (Cambridge) | 1999 | 192 |
| 48 | Developing a Quality of Cancer Survivorship Care Framework: Implications for Clinical Care, Research, and Policy | Journal of the National Cancer Institute | 2019 | 190 |
| 49 | Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer | Oncogene | 2011 | 187 |
| 50 | Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 187 |
