| # | Title | Journal | Year | Citations |
|---|
| 1 | A complementation analysis of the restriction and modification of DNA in Escherichia coli | Journal of Molecular Biology | 1969 | 4,258 |
| 2 | VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation | Nature Medicine | 1999 | 1,853 |
| 3 | Defective Repair Replication of DNA in Xeroderma Pigmentosum | Nature | 1968 | 1,672 |
| 4 | The molecular genetics of cancer | Science | 1987 | 1,659 |
| 5 | Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. | Journal of Experimental Medicine | 1989 | 1,476 |
| 6 | Molecular physiology of reverse cholesterol transport. | Journal of Lipid Research | 1995 | 1,283 |
| 7 | The island dilemma: Lessons of modern biogeographic studies for the design of natural reserves | Biological Conservation | 1975 | 1,240 |
| 8 | Microsomal Heme Oxygenase | Journal of Biological Chemistry | 1969 | 1,214 |
| 9 | Molecular physiology of reverse cholesterol transport | Journal of Lipid Research | 1995 | 1,000 |
| 10 | Characterization of ribosomal frameshifting in HIV-1 gag-pol expression | Nature | 1988 | 928 |
| 11 | Modulation of Inflammation and Immunity by Cyclic AMP | Science | 1974 | 920 |
| 12 | The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism | JAMA Surgery | 2016 | 840 |
| 13 | Minimum Alveolar Anesthetic Concentration | Anesthesiology | 1965 | 833 |
| 14 | Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth | Nature | 1987 | 742 |
| 15 | Detecting the threshold of anaerobic metabolism in cardiac patients during exercise | American Journal of Cardiology | 1964 | 714 |
| 16 | Guglielmi Detachable Coil embolization of cerebral aneurysms: 11 years' experience | Journal of Neurosurgery | 2003 | 710 |
| 17 | Total and Regional Coronary Blood Flow Measured by Radioactive Microspheres in Conscious and Anesthetized Dogs | Circulation Research | 1969 | 698 |
| 18 | Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study | Alzheimer's and Dementia | 2015 | 656 |
| 19 | Far-field acoustic response: origins in the cat | Science | 1975 | 649 |
| 20 | Human Auditory Evoked Potentials: Possible Brain Stem Components Detected on the Scalp | Science | 1970 | 642 |
| 21 | Early incorporation of cell-derived cholesterol into pre-.beta.-migrating high-density lipoprotein | Biochemistry | 1988 | 637 |
| 22 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias | Journal of the American College of Cardiology | 2003 | 632 |
| 23 | Clonal expansion of p53 mutant cells is associated with brain tumour progression | Nature | 1992 | 628 |
| 24 | Isolation of disaturated phosphatidylcholine with osmium tetroxide | Journal of Lipid Research | 1976 | 614 |
| 25 | Route of Passive Ion Permeation in Epithelia | Nature: New Biology | 1972 | 603 |
| 26 | Dynamics of Insulin Secretion by the Perfused Rat Pancreas | Endocrinology | 1968 | 592 |
| 27 | Interaction ofCandida albicanswith Human Leukocytes and Serum | Journal of Bacteriology | 1969 | 565 |
| 28 | Surgical Compared with Nonoperative Treatment for Lumbar Degenerative Spondylolisthesis | Journal of Bone and Joint Surgery - Series A | 2009 | 546 |
| 29 | Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 533 |
| 30 | The electroretinogram: Its components and their origins | Vision Research | 1968 | 512 |
| 31 | A Possible Precursor of Immunoglobulin Light Chains | Nature: New Biology | 1972 | 511 |
| 32 | Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate | FASEB Journal | 1998 | 499 |
| 33 | Breast Cancer Screening in Women at Higher-Than-Average Risk: Recommendations From the ACR | Journal of the American College of Radiology | 2018 | 494 |
| 34 | Density Compensation in Island Faunas | Ecology | 1972 | 480 |
| 35 | Outcome from head injury related to patient' age | Journal of Neurosurgery | 1988 | 478 |
| 36 | A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells | Nature | 1983 | 471 |
| 37 | Circulatory Changes during Growth in the Fetal Lamb | Circulation Research | 1970 | 465 |
| 38 | 2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection | American Journal of Transplantation | 2016 | 451 |
| 39 | Distinctive Neuropsychological Patterns in Frontotemporal Dementia, Semantic Dementia, And Alzheimer Disease | Cognitive and Behavioral Neurology | 2003 | 442 |
| 40 | Respiratory responses mediated through superficial chemosensitive areas on the medulla | Journal of Applied Physiology | 1963 | 441 |
| 41 | pH Directly Regulates Epidermal Permeability Barrier Homeostasis, and Stratum Corneum Integrity/Cohesion | Journal of Investigative Dermatology | 2003 | 441 |
| 42 | Consensus Conference Report | Circulation | 2002 | 434 |
| 43 | Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells. | EMBO Journal | 1989 | 421 |
| 44 | 24-HOUR AND 72-HOUR PRESERVATION OF CANINE KIDNEYS | Lancet, The | 1967 | 416 |
| 45 | Cation Requirements for Insulin Secretion in the Isolated Perfused Pancreas | Diabetes | 1966 | 410 |
| 46 | How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis? | Arthritis and Rheumatism | 1985 | 410 |
| 47 | Identification of noninvasive imaging surrogates for brain tumor gene-expression modules | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 408 |
| 48 | Philipp Bozzini (1773–1809) and the Lichtleiter | Urology | 1974 | 403 |
| 49 | Effect of a previous deep inspiration on airway resistance in man | Journal of Applied Physiology | 1961 | 401 |
| 50 | Nitrogen balance during intermittent dialysis therapy of uremia | Kidney International | 1978 | 391 |
