| # | Title | Journal | Year | Citations |
|---|
| 1 | A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer’s disease | Neurology | 2001 | 637 |
| 2 | LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β | Neuron | 2007 | 632 |
| 3 | Microglia in health and disease | Journal of Neuroscience Research | 2005 | 601 |
| 4 | Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D | PLoS Genetics | 2009 | 442 |
| 5 | Stem cell‐based cell therapy in neurological diseases: A review | Journal of Neuroscience Research | 2009 | 387 |
| 6 | Magnetic resonance imaging results of the PRISMS trial: A randomized, double-blind, placebo-controlled study of interferon-?1a in relapsing-remitting multiple sclerosis | Annals of Neurology | 1999 | 346 |
| 7 | Cervicovestibular rehabilitation in sport-related concussion: a randomised controlled trial | British Journal of Sports Medicine | 2014 | 288 |
| 8 | Fractalkine and fractalkine receptors in human neurons and glial cells | Journal of Neuroscience Research | 2002 | 215 |
| 9 | Efficacy of Donepezil on Behavioral Symptoms in Patients With Moderate to Severe Alzheimer's Disease | International Psychogeriatrics | 2002 | 211 |
| 10 | Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model | Journal of Neuroscience Research | 2010 | 209 |
| 11 | Botulinum toxin A as treatment for drooling saliva in PD | Neurology | 2000 | 204 |
| 12 | The Can-SAD Study: A Randomized Controlled Trial of the Effectiveness of Light Therapy and Fluoxetine in Patients With Winter Seasonal Affective Disorder | American Journal of Psychiatry | 2006 | 200 |
| 13 | Neural Stem Cell–Mediated Enzyme/Prodrug Therapy for Glioma: Preclinical Studies | Science Translational Medicine | 2013 | 194 |
| 14 | Efficacy of Donepezil on Maintenance of Activities of Daily Living in Patients with Moderate to Severe Alzheimer's Disease and the Effect on Caregiver Burden | Journal of the American Geriatrics Society | 2003 | 189 |
| 15 | Brain Tumor Tropism of Transplanted Human Neural Stem Cells Is Induced by Vascular Endothelial Growth Factor | Neoplasia | 2005 | 185 |
| 16 | Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis? | Journal of Psychiatry and Neuroscience | 2006 | 183 |
| 17 | Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease | Neurobiology of Disease | 2004 | 164 |
| 18 | Neural Stem Cell-Mediated Intratumoral Delivery of Gold Nanorods Improves Photothermal Therapy | ACS Nano | 2014 | 139 |
| 19 | Feelings of mental pollution subsequent to sexual assault | Behaviour Research and Therapy | 2004 | 134 |
| 20 | Definitions of dementia and predementia states in Alzheimer's disease and vascular cognitive impairment: consensus from the Canadian conference on diagnosis of dementia | Alzheimer's Research and Therapy | 2013 | 129 |
| 21 | PEX-Producing Human Neural Stem Cells Inhibit Tumor Growth in a Mouse Glioma Model | Clinical Cancer Research | 2005 | 128 |
| 22 | Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice | Gene Therapy | 2009 | 123 |
| 23 | Pathophysiology of seasonal affective disorder: a review | Journal of Psychiatry and Neuroscience | 2000 | 121 |
| 24 | Predictors of Continuous Positive Airway Pressure Adherence in Patients with Obstructive Sleep Apnea | Lung | 2019 | 120 |
| 25 | Neuroleptic Malignant Syndrome: A Review from a Clinically Oriented Perspective | Current Neuropharmacology | 2015 | 117 |
| 26 | Mutations in B4GALNT1 (GM2 synthase) underlie a new disorder of ganglioside biosynthesis | Brain | 2013 | 115 |
| 27 | Sleep disturbances and depression: a challenge for antidepressants | International Clinical Psychopharmacology | 2006 | 114 |
| 28 | Age Related Multiple Sclerosis Severity Score: Disability ranked by age | Multiple Sclerosis Journal | 2017 | 107 |
| 29 | Combining Antidepressants for Treatment-Resistant Depression | Journal of Clinical Psychiatry | 2002 | 103 |
| 30 | High incidence and increasing prevalence of multiple sclerosis in British Columbia, Canada: findings from over two decades (1991–2010) | Journal of Neurology | 2015 | 100 |
| 31 | Epidemiology of Sleep Disturbances and Cardiovascular Consequences | Canadian Journal of Cardiology | 2015 | 93 |
| 32 | Postthrombolysis Intracranial Hemorrhage Risk of Cerebral Microbleeds in Acute Stroke Patients: A Systematic Review and Meta-Analysis | International Journal of Stroke | 2013 | 90 |
| 33 | Economic evaluation of donepezil in moderate to severe Alzheimer disease | Neurology | 2004 | 88 |
| 34 | Magnetic Resonance Imaging Tracking of Ferumoxytol-Labeled Human Neural Stem Cells: Studies Leading to Clinical Use | Stem Cells Translational Medicine | 2013 | 88 |
| 35 | Colorectal cancer risk in Crohn’s disease | World Journal of Gastroenterology | 2008 | 84 |
| 36 | Cardiotoxicity and other adverse events associated with mitoxantrone treatment for MS | Neurology | 2010 | 82 |
| 37 | Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1) | International Journal of Stroke | 2018 | 82 |
| 38 | Sedation and Analgesia in the Interventional Radiology Department | Journal of Vascular and Interventional Radiology | 2003 | 80 |
| 39 | Effect of Selective Serotonin Reuptake Inhibitors in Alzheimer’s Disease with Comorbid Depression | Drugs and Aging | 2012 | 79 |
| 40 | Functional, Cognitive and Behavioral Effects of Donepezil in Patients with Moderate Alzheimer's Disease | Current Medical Research and Opinion | 2002 | 78 |
| 41 | Effect of electroconvulsive therapy on brain 5-HT2 receptors in major depression | British Journal of Psychiatry | 2010 | 76 |
| 42 | Clinical effectiveness: The importance of psychosocial functioning outcomes | Journal of Affective Disorders | 2011 | 76 |
| 43 | Human Neural Stem Cells Genetically Modified to Overexpress Akt1 Provide Neuroprotection and Functional Improvement in Mouse Stroke Model | PLoS ONE | 2009 | 76 |
| 44 | Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies | Neurobiology of Disease | 2003 | 73 |
| 45 | Sodium butyrate sensitizes human glioma cells to TRAIL-mediated apoptosis through inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP | Oncogene | 2005 | 73 |
| 46 | Early Switching Strategies in Antidepressant Non-Responders: Current Evidence and Future Research Directions | CNS Drugs | 2014 | 72 |
| 47 | Increasing incidence of myasthenia gravis among elderly in British Columbia, Canada | Neurology | 2011 | 71 |
| 48 | Cardiovascular Complications of Sleep Apnea: Role of Oxidative Stress | Oxidative Medicine and Cellular Longevity | 2014 | 71 |
| 49 | The public health and safety consequences of sleep disordersThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum. | Canadian Journal of Physiology and Pharmacology | 2007 | 70 |
| 50 | Production and Characterization of Immortal Human Neural Stem Cell Line with Multipotent Differentiation Property | Methods in Molecular Biology | 2008 | 69 |
